Regulation of immune responses by IL-15
Project/Area Number |
20591783
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kyushu University |
Principal Investigator |
HISAKATA Yamada Kyushu University, 生体防御医学研究所, 准教授 (20363369)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | リウマチ病学 |
Research Abstract |
In order to elucidate the pathogenesis of inflammatory diseases such as rheumatoid arthritis (RA), it is important to understand the mechanism of regulating T cell functions that play central role in immune responses. In the present study, we addressed the role of IL-15, one of the proinflammatory cytokines that are upregulated in RA, in T cell functions in vivo by using mouse models. We found IL-15 is especially important in the development, maintenance, and activation of self-specific T cells.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.2010
Author(s)
Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y.
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Journal Title
J Exp Med
Volume: 207
Pages: 721-30
Related Report
Peer Reviewed
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[Journal Article] Direct recognition of mycobacterial cord factor, trehalose dimycolate, by C-type lectin Mincle.2009
Author(s)
Ishikawa E, Ishikawa T, Morita Y, Toyonaga K, Yamada H, Takeuchi O, Akira S, Kinoshita T, Yoshikai Y. Yamasaki S.
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Journal Title
J Exp Med. 206(13)
Pages: 2879-2888
Related Report
Peer Reviewed
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[Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.2009
Author(s)
Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama K, Iwamoto Y, Yoshikai Y, Yamada H.
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Journal Title
J Immunol. 183(11)
Pages: 7539-7546
Related Report
Peer Reviewed
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[Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis2009
Author(s)
Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama K, Iwamoto Y, Yoshikai Y, Yamada H
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Journal Title
J Immunol. 183
Pages: 7539-7546
Related Report
Peer Reviewed
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[Journal Article] Direct recognition of mycobacterial cord factor, trehalose dimycolate, by C-type lectin Mincle2009
Author(s)
Ishikawa E, Ishikawa T, Morita Y, Toyonaga K, Yamada H, Takeuchi O, Akira S, Kinoshita T, Yoshikai Y, Yamasaki S
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Journal Title
J Exp Med. 206
Pages: 2879-2888
Related Report
Peer Reviewed
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[Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.2008
Author(s)
Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.
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Journal Title
Immunity. 29(3)
Pages: 438-450
Related Report
Peer Reviewed
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