Effects of volatile anesthetic(Sevoflurane) on cardiac rhythm and ion channels

Research Project

Project/Area Number	20591796
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Asahikawa Medical College
Principal Investigator	SUZUKI Akihiro Asahikawa Medical College, 医学部, 講師 (30292121)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	蘇生学 / セボフルラン / 一過性外向きK電流
Research Abstract	We electro-physiologically studied the effect of sevoflurane, a volatile anesthesthetic widely used in Japan, on transient outward K (Ito) channel and slow delayed rectifier K (IKs) channel using the patch clamp technique. Sevoflurane suppressed the Ito in a concentration dependent manner. Sevoflurane also suppressed the IKs transfected on HEK cell. Our result indicated that the sevoflurane prolongs action potential by suppressing these potassium channel and may have a similar effect as class III anti-arrythmia drugs.