Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
| Project/Area Number |
20591829
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SAKAUE Gaku Osaka University, 医学系研究科, 助教 (70379254)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Takaya 大阪大学, 大学院・医学系研究科, 寄附講座助教 (00335358)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 神経障害性疼痛 / グリア |
|---|
| Research Abstract |
Pro-inflammatory cytokines,generated from microglia or astrocyte, have been shown to be involved in the genesis, persistence, and severity of neuropathic pain following nerve injury. The transcription factor, NF-kappaB, plays a pivotal role in regulating pro-inflammatory cytokine gene expression. To elucidate the role of NF-kappaB in the pathogenesis of neuropathic pain, using a gene-based approach of NF-kappaB decoy, we tested whether the activated NF-kappaB affected pain behavior via the expression of inflammatory mediators.
|
Report
(4 results)
Research Products
(19 results)
