Analysis of Molecular Mechanism of Congenital hydronephrosis.

• Project/Area Number: 20591874
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: AOKI Yoshitaka University of Fukui, 医学部, 助教 (30273006)
• Co-Investigator(Kenkyū-buntansha): ITO Hideaki 福井大学, 医学部, 助教 (00345620) ; YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552) ; YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 転写因子 / 腎盂尿管移行部狭窄 / 分化 / アンギオテンシン受容体 / SNP / 先天性尿路奇形 / 転写制御 / 水腎症 / 動物モデル

Research Abstract

We recently showed that Id2 mutant mice develop hydronephrosis with congenital obstruction at the ureteropelvic junction, the characteristics of which show a close resemblance to those of human congenital hydronephrosis. We investigated whether Id2 was involved in the pathogenesis of hydronephrosis using unilateral ureteral obstruction (UUO) mouse model. After 3 days of UUO, Id2 gene expressions of renal pelvis were increased by 2.4-fold. Ingenuity pathway Analysis and microarray expression data analysis from public data database suggested that Id2 gene related with Angiotensinogen.

Research Products

• [Journal Article] Modulation of stretch evoked adenosine triphosphate release from bladder epithelium by prostaglandin E2. (2011)
  • Author(s): Tanaka I, Nagase K, Tanase K, Aoki Y, Akino H, Yokoyama O.
  • Journal Title: J Urol. 185(1) Pages: 341-316
  • Peer Reviewed
• [Journal Article] α1-adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume. (2011)
  • Author(s): Yokoyama O, Aoki Y, Tsujimura A, Takao T, Namiki M, Okuyama A.
  • Journal Title: World J Urol. 2011;29(2):233-8. 29(2) Pages: 233-238
  • Peer Reviewed
• [Journal Article] メタボリックシンドロームと排尿障害:メタボリックシンドロームと夜間頻尿 (2011)
  • Author(s): 青木芳隆, 横山修
  • Journal Title: 排尿障害プラクティス 19(1) Pages: 11-16
• [Journal Article] Urinary prostaglandin E2 was increased in patients with suprapontine brain diseases, and associated with overactive bladder syndrome. (2010)
  • Author(s): Yamauchi H, Akino H, Ito H, Aoki Y, Nomura T, Yokoyama O.
  • Journal Title: Urology. 76(5)
  • Peer Reviewed
• [Journal Article] Improvement in neurogenic detrusor overactivity by peripheral C fiber's suppression with cyclooxygenase inhibitors. (2010)
  • Author(s): Tanaka I, Nagase K, Tanase K, Aoki Y, Akino H, Yokoyama O.
  • Journal Title: J Urol. 183(2) Pages: 786-792
  • Peer Reviewed
• [Journal Article] Selective α1A-blocker improves bladder storage function in rats via suppression of C-fiber afferent activity. (2010)
  • Author(s): Yokoyama O, Ito H, Aoki Y, Oyama N, Miwa Y, Akino H.
  • Journal Title: World J Urol. 28(5) Pages: 609-614
  • Peer Reviewed
• [Journal Article] 生活習慣病と夜間頻尿. (2010)
  • Author(s): 青木芳隆, 横山修
  • Journal Title: Urology View 8(3) Pages: 28-32
• [Journal Article] Long-lasting breaches in the bladder eqithelium lead to storage dysfunction with increase in bladder PGE2 levels in the rat. (2008)
  • Author(s): Shioyama R, Aoki Y, Ito H, Matsuta Y, Nagase K, Oyama N, Miwa Y, Akino H, Imamura Y, Yokoyama O.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 295(2)
  • Peer Reviewed
• [Journal Article] Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension. (2008)
  • Author(s): Gratze P, Dechend R, Stocker C, Park JK, Feldt S, Shagdarsuren E, Wellner M, Gueler F, Rong S, Gross V, Obst M, Plehm R, Alenina N, Zenclussen A, Titze J, Small K, Yokota Y, Zenke M, Luft FC, Muller DN
  • Journal Title: Circulation 117(20) Pages: 2645-2656
  • Peer Reviewed
• [Presentation] 先天性水腎症の家族内発症例におけるId2遺伝子変異解析(第1報) (2010)
  • Author(s): 青木芳隆、坂井清英、横山修
  • Organizer: 第19回日本小児泌尿器科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-02
• [Presentation] 先天性水腎症の家族内発症例におけるId2遺伝子変異解析(第1報) (2010)
  • Author(s): 青木芳隆
  • Organizer: 第19回日本小児泌尿器科学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-02
• [Remarks] ホームページ等
  • URL: http://www.med.u-fukui.ac.jp/SEIKA1/
• [Remarks]
  • URL: http://www.hosp.u-fukui.ac.jp/03sinryou/new/02-05-02.html
• [Remarks]
  • URL: http://www.med.u-fukui.ac.jp/SEIKAI/