Neuromodulation for impaired bladder function on regenerative medicine

• Project/Area Number: 20591890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Meiji College of Oriental Medicine
• Principal Investigator: HONJO Hisashi Meiji College of Oriental Medicine, 鍼灸学部, 講師 (30351357)
• Co-Investigator(Kenkyū-buntansha): OKADA Koichi 明治国際医療大学, 医学教育研究センター, 講師 (10326233) ; KITAKOJI Hiroshi 明治国際医療大学, 鍼灸学部, 教授 (70204881) ; NAKAO Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (00188880)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 膀胱機能障害 / 脊髄損傷 / 再生医療 / Neuromodulation / 鍼刺激

Research Abstract

We investigated the effects of neuromodulation by acupuncture stimulation for the impaired bladder function in rats. In this study we revealed that sacral acupuncture stimulation inhibited non-voiding bladder contraction (NVC) during storage phage in rats with spinal cord injury. Additionally、we clarified that that sacral acupuncture stimulation inhibited NVC during storage phage in rats with bladder outlet obstruction. We conclude that sacral acupuncture stimulation affect inhibition on bladder hyperactivity during storage phage.

Research Products

• [Journal Article] Analysis of nocturia with 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration : concept for effective treatment modality (2011)
  • Author(s): Udo Y, Nakao M, Honjo H, Ukimura O, Kawauchi A, Kitakoji H, Miki T
  • Journal Title: BJU International Volume: 107 Pages: 791-798
  • Peer Reviewed
• [Journal Article] Impact of convenience void in a bladder diary with urinary perception grade to assess overactive bladder symptoms : a Community-Based Study. (2010)
  • Author(s): Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
  • Journal Title: Neurourol Urodyn 29 Pages: 1286-1289
• [Journal Article] The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats. (2010)
  • Author(s): Hino K, Honjo H, Nakao M, Kitakoji H
  • Journal Title: Urology 75 Pages: 730-734
• [Journal Article] Analysis of nocturia with 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration : concept for effective treatment modality. (2010)
  • Author(s): Udo Y, Nakao M, Honjo H, Kitakoji H, Ukimura O, Kawauchi A, Miki T
  • Journal Title: BJU Int 107 Pages: 791-798
• [Journal Article] Impact of convenience void in a bladder diary with urinary perceptiongrade to assess overactive bladder symptoms : a community-based study (2010)
  • Author(s): Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
  • Journal Title: Neurourology and Urodynamics Volume: 29 Pages: 1286-1289
  • Peer Reviewed
• [Journal Article] The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats (2010)
  • Author(s): Hino K, Honjo H, Nakao M, Kitakoji H
  • Journal Title: Urology 75 Pages: 730-734
  • Peer Reviewed
• [Journal Article] Analysis of bladder diary with urinary perception to assess overactive bladder symptoms in community-dwelling women. (2009)
  • Author(s): Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
  • Journal Title: Neurourol Urodyn 28 Pages: 982-985
• [Journal Article] Sleep duration is an independent factor in nocturia : analysis of bladder diaries. (2009)
  • Author(s): Udo Y, Nakao M, Honjo H, Ukimura O, Kitakoji H, Miki T
  • Journal Title: BJU Int 104 Pages: 75-79
• [Journal Article] Analysis of bladder diary with urinary perception to assess overactive bladder symptoms in community-dwelling women (2009)
  • Author(s): Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
  • Journal Title: Neurourology and Urodynamics 28 Pages: 982-985
  • Peer Reviewed
• [Journal Article] Sleep duration is an independent factor in nocturia : analysis of bladder diaries (2009)
  • Author(s): Udo Y, Nakao M, Honjo H, Ukimura O, Kitakoji H, Miki T
  • Journal Title: BJU International 104 Pages: 75-79
  • Peer Reviewed
• [Presentation] Serum NOx levels associated with the average voided volume in women with OAB (2010)
  • Author(s): Honjo H
  • Organizer: EAU 2010
  • Place of Presentation: バルセロナ
  • Year and Date: 2010-04-19
• [Presentation] Serum NOx levels associated with the average voided volume in women with OAB. (2010)
  • Author(s): Honjo H, Nakao M, Ueyama J, Kondo T, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
  • Organizer: 25th Annual EAU Congress(Eur Urol Suppl 9(2),251-252 (Abstract #782))
• [Presentation] Serum NOx levels associated with the voided volume in community-dwelling women with overactive bladder. (2010)
  • Author(s): Honjo H, Nakao M, Ueyama J, Kondo T, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
  • Organizer: 105th AUA Annual Meeting(J Urol 183(4) Suppl, e588-589 (Abstract #1526))
• [Presentation] Effects of sacral acupuncture in a rat cystitis model induced by intravesical hydrochloric acid. (2010)
  • Author(s): Hino K, Honjo H, Nakao M, Kitakoji H
  • Organizer: ICS Meeting 2010, Abstracts of ICS 2010(Abstract #566)
• [Presentation] Impact of convenience void in bladder diary which involves self-reported urinary perception to assess overactive bladder sensitivity (2009)
  • Author(s): Honjo H
  • Organizer: ICS 2009(国際尿禁制学会)
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2009-10-01
• [Presentation] The correlation between metabolic syndrome and OAB-wet in middle-aged and elderly community-dwelline women (2009)
  • Author(s): Honjo H
  • Organizer: AUA 2009(アメリカ泌尿器科学会)
  • Place of Presentation: シカゴ
  • Year and Date: 2009-04-29
• [Presentation] The correlation between OAB-wet and serum adiponectin level, serum marker of metabolic syndrome in middle-aged and elderly community-dwelling women. (2009)
  • Author(s): Honjo H, Nakao M, Suzuki K, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
  • Organizer: 24th Annual Congress of the European Association of Urology, European Urology(Supplements, 8(4): 137)
• [Presentation] The correlation between metabolic syndrome and OAB-wet in middle-aged and elderly community-dwelling women. (2009)
  • Author(s): Honjo H, Nakao M, Kitakoji H, Suzuki K, Hamajima N, Ukimura O, Kawauchi A, Miki T
  • Organizer: 2009 Annual Meeting of the American Urological Association, The Journal of Urology, 181(4): 674-675)
• [Presentation] Impact of convenience void in bladder diary which involves self-reported urinary perception to assess overactive bladder sensitivity. (2009)
  • Author(s): Honjo H, Ukimura O, Kawauchi A, Kitakoji H, Nakao M, Miki T
  • Organizer: 39th Annual Meeting of the International Continence Society, Neurourol Urodyn, 28(7): 604-605)
• [Presentation] 下部尿路閉塞モデルラットの膀胱機能に与える仙骨部鍼刺激の影響 (2009)
  • Author(s): 島荘徳,本城久司,日野こころ,岡田晃一,中尾昌宏,北小路博司
  • Organizer: 第16回日本排尿機能学会(日本排尿機能学会抄録集 144)
• [Book] 最新の診断と治療(三木恒治,中尾昌宏編)(よくわかる排尿トラブルの対処法) (2008)
  • Author(s): 本城久司(共著)
  • Publisher: 昭和堂
• [Book] よくわかる排尿トラブルの対処法 (2008)
  • Author(s): 本城久司(三木恒治, 中尾昌宏編)
  • Total Pages: 127
  • Publisher: 昭和堂
• [Remarks] ホームページ等