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Neuromodulation for impaired bladder function on regenerative medicine

Research Project

Project/Area Number 20591890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionMeiji College of Oriental Medicine

Principal Investigator

HONJO Hisashi  Meiji College of Oriental Medicine, 鍼灸学部, 講師 (30351357)

Co-Investigator(Kenkyū-buntansha) OKADA Koichi  明治国際医療大学, 医学教育研究センター, 講師 (10326233)
KITAKOJI Hiroshi  明治国際医療大学, 鍼灸学部, 教授 (70204881)
NAKAO Masahiro  明治国際医療大学, 医学教育研究センター, 教授 (00188880)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords膀胱機能障害 / 脊髄損傷 / 再生医療 / Neuromodulation / 鍼刺激
Research Abstract

We investigated the effects of neuromodulation by acupuncture stimulation for the impaired bladder function in rats. In this study we revealed that sacral acupuncture stimulation inhibited non-voiding bladder contraction (NVC) during storage phage in rats with spinal cord injury. Additionally、we clarified that that sacral acupuncture stimulation inhibited NVC during storage phage in rats with bladder outlet obstruction. We conclude that sacral acupuncture stimulation affect inhibition on bladder hyperactivity during storage phage.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Analysis of nocturia with 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration : concept for effective treatment modality2011

    • Author(s)
      Udo Y, Nakao M, Honjo H, Ukimura O, Kawauchi A, Kitakoji H, Miki T
    • Journal Title

      BJU International

      Volume: 107 Pages: 791-798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of convenience void in a bladder diary with urinary perception grade to assess overactive bladder symptoms : a Community-Based Study.2010

    • Author(s)
      Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
    • Journal Title

      Neurourol Urodyn 29

      Pages: 1286-1289

    • Related Report
      2010 Final Research Report
  • [Journal Article] The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats.2010

    • Author(s)
      Hino K, Honjo H, Nakao M, Kitakoji H
    • Journal Title

      Urology 75

      Pages: 730-734

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis of nocturia with 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration : concept for effective treatment modality.2010

    • Author(s)
      Udo Y, Nakao M, Honjo H, Kitakoji H, Ukimura O, Kawauchi A, Miki T
    • Journal Title

      BJU Int 107

      Pages: 791-798

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of convenience void in a bladder diary with urinary perceptiongrade to assess overactive bladder symptoms : a community-based study2010

    • Author(s)
      Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
    • Journal Title

      Neurourology and Urodynamics

      Volume: 29 Pages: 1286-1289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of sacral acupuncture on acetic acid-induced bladder irritation in conscious rats2010

    • Author(s)
      Hino K, Honjo H, Nakao M, Kitakoji H
    • Journal Title

      Urology 75

      Pages: 730-734

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of bladder diary with urinary perception to assess overactive bladder symptoms in community-dwelling women.2009

    • Author(s)
      Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
    • Journal Title

      Neurourol Urodyn 28

      Pages: 982-985

    • Related Report
      2010 Final Research Report
  • [Journal Article] Sleep duration is an independent factor in nocturia : analysis of bladder diaries.2009

    • Author(s)
      Udo Y, Nakao M, Honjo H, Ukimura O, Kitakoji H, Miki T
    • Journal Title

      BJU Int 104

      Pages: 75-79

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis of bladder diary with urinary perception to assess overactive bladder symptoms in community-dwelling women2009

    • Author(s)
      Honjo H, Kawauchi A, Ukimura O, Nakao M, Kitakoji H, Miki T
    • Journal Title

      Neurourology and Urodynamics 28

      Pages: 982-985

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep duration is an independent factor in nocturia : analysis of bladder diaries2009

    • Author(s)
      Udo Y, Nakao M, Honjo H, Ukimura O, Kitakoji H, Miki T
    • Journal Title

      BJU International 104

      Pages: 75-79

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Serum NOx levels associated with the average voided volume in women with OAB2010

    • Author(s)
      Honjo H
    • Organizer
      EAU 2010
    • Place of Presentation
      バルセロナ
    • Year and Date
      2010-04-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum NOx levels associated with the average voided volume in women with OAB.2010

    • Author(s)
      Honjo H, Nakao M, Ueyama J, Kondo T, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
    • Organizer
      25th Annual EAU Congress(Eur Urol Suppl 9(2),251-252 (Abstract #782))
    • Related Report
      2010 Final Research Report
  • [Presentation] Serum NOx levels associated with the voided volume in community-dwelling women with overactive bladder.2010

    • Author(s)
      Honjo H, Nakao M, Ueyama J, Kondo T, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
    • Organizer
      105th AUA Annual Meeting(J Urol 183(4) Suppl, e588-589 (Abstract #1526))
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of sacral acupuncture in a rat cystitis model induced by intravesical hydrochloric acid.2010

    • Author(s)
      Hino K, Honjo H, Nakao M, Kitakoji H
    • Organizer
      ICS Meeting 2010, Abstracts of ICS 2010(Abstract #566)
    • Related Report
      2010 Final Research Report
  • [Presentation] Impact of convenience void in bladder diary which involves self-reported urinary perception to assess overactive bladder sensitivity2009

    • Author(s)
      Honjo H
    • Organizer
      ICS 2009(国際尿禁制学会)
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] The correlation between metabolic syndrome and OAB-wet in middle-aged and elderly community-dwelline women2009

    • Author(s)
      Honjo H
    • Organizer
      AUA 2009(アメリカ泌尿器科学会)
    • Place of Presentation
      シカゴ
    • Year and Date
      2009-04-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] The correlation between OAB-wet and serum adiponectin level, serum marker of metabolic syndrome in middle-aged and elderly community-dwelling women.2009

    • Author(s)
      Honjo H, Nakao M, Suzuki K, Ukimura O, Kawauchi A, Kitakoji H, Hamajima N, Miki T
    • Organizer
      24th Annual Congress of the European Association of Urology, European Urology(Supplements, 8(4): 137)
    • Related Report
      2010 Final Research Report
  • [Presentation] The correlation between metabolic syndrome and OAB-wet in middle-aged and elderly community-dwelling women.2009

    • Author(s)
      Honjo H, Nakao M, Kitakoji H, Suzuki K, Hamajima N, Ukimura O, Kawauchi A, Miki T
    • Organizer
      2009 Annual Meeting of the American Urological Association, The Journal of Urology, 181(4): 674-675)
    • Related Report
      2010 Final Research Report
  • [Presentation] Impact of convenience void in bladder diary which involves self-reported urinary perception to assess overactive bladder sensitivity.2009

    • Author(s)
      Honjo H, Ukimura O, Kawauchi A, Kitakoji H, Nakao M, Miki T
    • Organizer
      39th Annual Meeting of the International Continence Society, Neurourol Urodyn, 28(7): 604-605)
    • Related Report
      2010 Final Research Report
  • [Presentation] 下部尿路閉塞モデルラットの膀胱機能に与える仙骨部鍼刺激の影響2009

    • Author(s)
      島荘徳,本城久司,日野こころ,岡田晃一,中尾昌宏,北小路博司
    • Organizer
      第16回日本排尿機能学会(日本排尿機能学会抄録集 144)
    • Related Report
      2010 Final Research Report
  • [Book] 最新の診断と治療(三木恒治,中尾昌宏編)(よくわかる排尿トラブルの対処法)2008

    • Author(s)
      本城久司(共著)
    • Publisher
      昭和堂
    • Related Report
      2010 Final Research Report
  • [Book] よくわかる排尿トラブルの対処法2008

    • Author(s)
      本城久司(三木恒治, 中尾昌宏編)
    • Total Pages
      127
    • Publisher
      昭和堂
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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