Detection of immunoresponse to flame-shift proteins in MSI positive endometrial cancer patients.
| Project/Area Number |
20591960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
IWATA Takashi Keio University, 医学部, 助教 (30296652)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tomonobu 慶應義塾大学, 医学部, 助教 (20199334)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 子宮体癌 / MSI / フレームシフト / 免疫応答 / 変異タンパク / 免疫療法 / MYEOV |
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| Research Abstract |
To detect specific immune response to flame-shift proteins in MSI positive endometrial cancer patients, we synthesized MSI associated flame-shift peptides, and evaluated antibodies to these peptides in MSI positive patients' sera. But none of MSI positive patients had specific antibodies to MSI associated peptides. We detected MYEOV protein by SEREX method using SCID mouse sera ,these mice was transplantated MSI positive endometrial cancer tissues. MYEOV was associated with invasion and migration in endometrial cancer cells, and was prognostic factor in endometrial cancer.
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Report
(4 results)
Research Products
(1 results)
