Identification of novel GPCR coupled to histamine H4 receptor agonists and its use for the treatment of allergic rhinitis
| Project/Area Number |
20592001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
OKANO Mitsuhiro (2009-2010) Okayama University, 大学院・医歯薬学総合研究科, 准教授 (60304359)
冨永 進 (2008) Okayama University, 医学部・歯学部附属病院, 講師 (70420487)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Susumu 岡山大学, 医学部・歯学部附属病院, 講師 (70420487)
岡野 光博 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60304359)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ヒスタミン / アレルギー性鼻炎 / メラノコルチン受容体 / α-メラノサイト刺激ホルモン / サイトカイン / 共刺激分子 / H4受容体 / メラノコルチン1受容体 / メラノサイト刺激ホルモン / IgE / B細胞 / CD40 / IL-4 / リンパ球 / T細胞 |
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| Research Abstract |
Histamine H4 receptor (H4R) agonists suppress allergen-specific cytokine production in humans. H4R agonists induced melanocortin 1 receptor, the GPCR, expression in peripheral blood mononuclear cells. Alpha-melanocyte stimulating hormone (α-MSH), the ligand to melanocortin 1 receptor, suppresses allergen-specific cytokine production and co-stimulatory molecule expression on B cells and monocytes. These results suggest that H4R agonists and analogues related toα-MSH are therapeutic targets for allergic rhinitis.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Allergen-specific immunotherapy alters the expression of BTLA, a co-inhibitory molecule, in allergic rhinitis2008
Author(s)
Okano M, Otsuki N, Azuma M, Fujiwara T, Kariya S, Sugata Y, Higaki T, Kino K, Tanimoto Y, Okubo K, Nishizaki K
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Journal Title
Clinical and Experimental Allergy 38巻
Pages: 1891-1900
Related Report
Peer Reviewed
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[Journal Article] CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice2008
Author(s)
Nomiya R, Okano M, Fujiwara T, Maeda M, Kimura Y, Kino K, Yokoyama M, Hirai H, Nagata K, Hara T, Nishizaki K, Nakamura M
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Journal Title
Journal of Immunology 180巻
Pages: 5680-5688
NAID
Related Report
Peer Reviewed
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