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Development of New Treatment Strategies for Chronic Rhinosinusitis Based on Epigenetic Analysis

Research Project

Project/Area Number 20592004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

YOSHIKAWA Mamoru  Jikei University School of Medicine, 医学部, 講師 (50277092)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインターフェロン誘導性遺伝子 / ウィルス感染 / エピジェネティック解析 / 気管支喘息 / 慢性副鼻腔炎 / 自然免疫 / 線維芽細胞
Research Abstract

As a results of investigation of clinical background concerning intractable chronic rhinosinusitis, we thought that nasal sinus mucosa differences in reactivity against virus infection exists. We verified whether or not the expression of IFN-induced genes such as IP-10 and I-TAC, compares the before and after the incubation with DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors. We identified that histone acetylation is involved in transcriptional regulation. We targeted to drug discovery for epigenetic control as effective therapy for intractable chronic rhinosinusitis in the future.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Book (1 results)

  • [Journal Article] 培養中耳粘膜における上皮間葉相互作用についての基礎的検討2010

    • Author(s)
      吉川衛, 他
    • Journal Title

      耳鼻咽喉科展望

      Volume: 53 Pages: 408-414

    • NAID

      130004911744

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between the prostaglandin D_2/E_2 ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma.2008

    • Author(s)
      Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H
    • Journal Title

      Allergol Int. 57(4)

      Pages: 429-36

    • NAID

      10025108762

    • Related Report
      2010 Final Research Report
  • [Journal Article] 喘息を合併する慢性副鼻腔炎におけるロイコトリエンの関与について2008

    • Author(s)
      吉村剛,吉川衛,鴻信義,春名眞一,森山寛
    • Journal Title

      耳展 51(1)

      Pages: 26-32

    • NAID

      130004546220

    • Related Report
      2010 Final Research Report
  • [Presentation] Correlation between the Prostaglandin D_2/E_2 Ratio in Nasal polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma2010

    • Author(s)
      Mamoru Yoshikawa
    • Organizer
      29^<th> Congress of the European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      イギリス・ロンドン
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation between the Prostaglandin D_2/E_2 Ratio in Nasal polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma.2010

    • Author(s)
      Yoshikawa M, Yoshimura T, Otori N, Haruna S, Moriyama H
    • Organizer
      29th EAACI Annual Congress
    • Place of Presentation
      London
    • Related Report
      2010 Final Research Report
  • [Presentation] 好酸球性副鼻腔炎の診断基準に関する検討2010

    • Author(s)
      中山次久,浅香大也,大櫛哲史,松脇由典,吉川衛,鴻信義,森山寛
    • Organizer
      日本鼻科学会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] 培養中耳粘膜組織作成における線維芽細胞がおよぼす上皮細胞への作用についての基礎的検討2009

    • Author(s)
      吉川衛
    • Organizer
      日本耳科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Book] 今日の耳鼻咽喉科頭頸部外科治療指針 第3版(森山寛 他編)(DNAチップによる遺伝子発現解析)2008

    • Author(s)
      吉川衛
    • Publisher
      東京;医学書院
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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