Development of New Treatment Strategies for Chronic Rhinosinusitis Based on Epigenetic Analysis

• Project/Area Number: 20592004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: YOSHIKAWA Mamoru Jikei University School of Medicine, 医学部, 講師 (50277092)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インターフェロン誘導性遺伝子 / ウィルス感染 / エピジェネティック解析 / 気管支喘息 / 慢性副鼻腔炎 / 自然免疫 / 線維芽細胞

Research Abstract

As a results of investigation of clinical background concerning intractable chronic rhinosinusitis, we thought that nasal sinus mucosa differences in reactivity against virus infection exists. We verified whether or not the expression of IFN-induced genes such as IP-10 and I-TAC, compares the before and after the incubation with DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors. We identified that histone acetylation is involved in transcriptional regulation. We targeted to drug discovery for epigenetic control as effective therapy for intractable chronic rhinosinusitis in the future.

Research Products

• [Journal Article] 培養中耳粘膜における上皮間葉相互作用についての基礎的検討 (2010)
  • Author(s): 吉川衛, 他
  • Journal Title: 耳鼻咽喉科展望 Volume: 53 Pages: 408-414
  • NAID: 130004911744
  • Peer Reviewed
• [Journal Article] Correlation between the prostaglandin D_2/E_2 ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. (2008)
  • Author(s): Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H
  • Journal Title: Allergol Int. 57(4) Pages: 429-36
  • NAID: 10025108762
• [Journal Article] 喘息を合併する慢性副鼻腔炎におけるロイコトリエンの関与について (2008)
  • Author(s): 吉村剛,吉川衛,鴻信義,春名眞一,森山寛
  • Journal Title: 耳展 51(1) Pages: 26-32
  • NAID: 130004546220
• [Presentation] Correlation between the Prostaglandin D_2/E_2 Ratio in Nasal polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma (2010)
  • Author(s): Mamoru Yoshikawa
  • Organizer: 29^<th> Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: イギリス・ロンドン
  • Year and Date: 2010-06-07
• [Presentation] Correlation between the Prostaglandin D_2/E_2 Ratio in Nasal polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma. (2010)
  • Author(s): Yoshikawa M, Yoshimura T, Otori N, Haruna S, Moriyama H
  • Organizer: 29th EAACI Annual Congress
  • Place of Presentation: London
• [Presentation] 好酸球性副鼻腔炎の診断基準に関する検討 (2010)
  • Author(s): 中山次久,浅香大也,大櫛哲史,松脇由典,吉川衛,鴻信義,森山寛
  • Organizer: 日本鼻科学会
  • Place of Presentation: 札幌
• [Presentation] 培養中耳粘膜組織作成における線維芽細胞がおよぼす上皮細胞への作用についての基礎的検討 (2009)
  • Author(s): 吉川衛
  • Organizer: 日本耳科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-10
• [Book] 今日の耳鼻咽喉科頭頸部外科治療指針 第3版(森山寛 他編)(DNAチップによる遺伝子発現解析) (2008)
  • Author(s): 吉川衛
  • Publisher: 東京;医学書院