The clinical analysis to induction of Japanese cedar pollinosis in pollen challenge chamber

• Project/Area Number: 20592006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Osaka Medical College
• Principal Investigator: TAKENAKA Hiroshi Osaka Medical College, 学長 (40137162)
• Co-Investigator(Kenkyū-buntansha): HYO Sawako 大阪医科大学, 非常勤医師 (50469219)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: スギ花粉症 / 花粉曝露質 / ヒト非シーズンスギ花粉症発症モデル / 薬効検定 / RCT / 花粉暴露室 / 症状誘発の定量化 / 薬物の効果判定 / 季節外誘発 / 花粉曝露室 / 定量的花粉曝露 / 非飛散期誘発試験 / ボランティア / 鼻腔最小面積 / スギ花粉曝露試験 / 非飛散期 / 鼻腔洗浄液 / CysLTs / CysLT1R / IL-4 / IFNγ

Research Abstract

More than 25% of Japanese seems to be suffered on Japanese cedar pollinosis. However, annual pollen dispersion was depend on weather and latitude of the land. So, there are few evidences about the standard drug therapy of Japanese cedar pollinosis.
Our pollen challenge chamber, have to make constant pollen dispersion to the person in the room, was examined for clinical experiment. The temporal and spatial variations of the pollen level in the chamber were small, facilitating stable pollen challenge, and pollinosis symptoms were induced in the volunteers with cedar pollinosis. The challenge chamber may be useful to judge the effects of therapy against pollinosis.

Research Products

• [Journal Article] Preliminary study of a challenge test to the patients with Japanese cedar pollinosis using an environmental exposure unit. (2010)
  • Author(s): Ito K, Terada T, Yuki A, Ichihara T, Hyo S, Kawata R, Takenaka H, Amano K, Ishiguro T, Ro T
  • Journal Title: Auris Nasus Larynx. 237(6) Pages: 644-649
• [Journal Article] Preliminary study of a challenge test to the patients with Japanese cedar pollinosis using an environmental exposure unit. (2010)
  • Author(s): Ito K, Terada T, Yuki A, Ichihara T, Hyo S, Kawata R, Takenaka H, Amano K, Ishiguro T, Ro T.
  • Journal Title: Auris Nasus Larynx.2 Volume: 37(6) Pages: 694-649
  • Peer Reviewed
• [Journal Article] 気道アレルギーの成立とその制御 (2009)
  • Author(s): 竹中洋
  • Journal Title: 日耳鼻 112 Pages: 200-2
  • NAID: 10024836218
• [Journal Article] Allergic Potency of Japanese cedar pollen Cry j 1 is reduced by a low concentration of hypochlorous acid generated by electolysis. (2009)
  • Author(s): Terada T, Akimoto Y, Hyo S, Suzuki D,Tanaka K, Takenaka H
  • Journal Title: Allergol Int 58 Pages: 255-60
  • NAID: 10025109792
• [Journal Article] A 13-year Study of Japanese Cedar Pollinosis in Japanese Schoolchildren. (2008)
  • Author(s): Ozasa K, Hama T, Dejima K, Watanabe Y, Hyo S,Terada T, Araki N, Takenaka H
  • Journal Title: Allergol Int 57 Pages: 175-80
  • NAID: 10021246646
• [Journal Article] Effect of local nasal immunotherapy on nasal blockage in pollen-induced allergic rhinitis of Guinea pigs. (2008)
  • Author(s): Nabe T, Kubota K, Mizutani N, Fujii M, Terada T, Takenaka H, Kohno S
  • Journal Title: Allergol Int 57 Pages: 419-27
  • NAID: 10025108738
• [Journal Article] Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber Allegology international
  • Author(s): Ayumi Yuki, Tetsuya Terada, Takahiro Ichihara, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka
• [Journal Article] Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber
  • Author(s): Ayumi Yuki, Tetsuya Terada, Takahiro Ichihara, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka
  • Journal Title: Allegology international Volume: (in press)
  • NAID: 130004477116
  • Peer Reviewed
• [Presentation] 花粉曝露室の実際ー抗原曝露室で分かったことー (2010)
  • Author(s): 寺田哲也、竹中洋
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-09
• [Presentation] 花粉曝露室の実際-抗原曝露室で分かったこと- (2010)
  • Author(s): 寺田哲也、竹中洋
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-09
• [Presentation] CLINICAL EFFECTS OF MONTELUKAST SODIUM,A LEUKOTRIENE RECEPTOR ANTAGONIST, IN JAPANESE CEDAR POLLINOSIS USING THE ALLERGEN CHALLENGE CHAMBER. (2009)
  • Author(s): Ito K, Takenaka H
  • Organizer: The XXI World Allergy Congress 2009(世界アレルギー学会)
  • Place of Presentation: Argentina
  • Year and Date: 2009-12-10
• [Presentation] 花粉曝露試験室を用いたモンテルカストのスギ花粉治療に対する検討 (2009)
  • Author(s): 伊藤加奈子,竹中洋,櫟原崇宏,柚木歩,兵佐和子,寺田哲也
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-31
• [Presentation] 花粉曝露試験室を用いたモンテルカストのスギ花粉治療に対する検討 (2009)
  • Author(s): 伊藤加奈子, 竹中洋, 櫟原崇宏, 柚木歩, 兵佐和子, 寺田哲也
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田ビューホテル(秋田県)
  • Year and Date: 2009-10-31
• [Presentation] スギ花粉症に対するモンテルカストの薬効評価-花粉曝露試験室における検討- (2009)
  • Author(s): 伊藤加奈子,竹中洋,櫟原崇宏,柚木歩,兵佐和子,寺田哲也
  • Organizer: 第48回日本鼻科学会
  • Place of Presentation: 島根
  • Year and Date: 2009-10-02
• [Presentation] スギ花粉症に対するモンテルカスト(シングレア)の薬効評価―花粉曝露試験室における検討― (2009)
  • Author(s): 伊藤加奈子, 竹中洋, 櫟原崇宏, 柚木歩, 兵佐和子, 寺田哲也
  • Organizer: 第48回日本鼻科学会
  • Place of Presentation: 島根県民会館(島根県)
  • Year and Date: 2009-10-02
• [Presentation] スギ花粉抗原投与によるIgE産生機構-IgE陽性細胞産生について- (2009)
  • Author(s): 東野昌子,平野雅予,中西仁美,紀本有実子,桜井幹士,山路純子,窪田隆裕,吉田龍太郎,竹中洋
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-16
• [Presentation] 花粉曝露室を用いた薬効評価 (2009)
  • Author(s): 伊藤加奈子,櫟原崇宏,柚木歩,兵佐和子,寺田哲也,竹中洋
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-16
• [Presentation] 気道アレルギーの成立とその制御 (2009)
  • Author(s): 竹中洋
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] 気道アレルギーの成立とその制御 (2009)
  • Author(s): 竹中洋
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: ザ・プリンスパークタワー東京(東京都)
  • Year and Date: 2009-05-14
• [Presentation] 花粉曝露実験室を用いたプランルカストの薬効評価 (2008)
  • Author(s): 伊藤加奈子,櫟原崇宏,柚木歩,兵佐和子,寺田哲也,竹中洋
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-29
• [Presentation] IgE産生に関する諸問題 (2008)
  • Author(s): 竹中洋
  • Organizer: 第1回旭川アレルギー性鼻炎セミナー
  • Place of Presentation: 北海道
  • Year and Date: 2008-05-29
• [Presentation] スギ花粉特異的IgEの産生機構-スギ花粉投与部位による相違 (2008)
  • Author(s): 桜井幹士,吉田龍太郎,紀本有実子,李昊哲,山口智子,東野昌子,竹中洋
  • Organizer: 第109回日本耳鼻咽喉科学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-16
• [Presentation] 花粉曝露実験室を用いたスギ花粉症に関する検討 (2008)
  • Author(s): 柚木歩,兵佐和子,伊藤加奈子,寺田哲也,竹中洋
  • Organizer: 第109回日本耳鼻咽喉科学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-16
• [Presentation] Epidemiological Study of Japanese Cedar Pollinosis in Japanese. (2008)
  • Author(s): 竹中洋
  • Organizer: The 35^<th> Congress of the Korean Rhinologic Society
  • Place of Presentation: Korea
  • Year and Date: 2008-03-09
• [Book] 気道アレルギーの成立とその制御 (2009)
  • Author(s): 竹中洋著
  • Publisher: 中西印刷株式会社
• [Remarks] ホームページ等