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The clinical analysis to induction of Japanese cedar pollinosis in pollen challenge chamber

Research Project

Project/Area Number 20592006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionOsaka Medical College

Principal Investigator

TAKENAKA Hiroshi  Osaka Medical College, 学長 (40137162)

Co-Investigator(Kenkyū-buntansha) HYO Sawako  大阪医科大学, 非常勤医師 (50469219)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsスギ花粉症 / 花粉曝露質 / ヒト非シーズンスギ花粉症発症モデル / 薬効検定 / RCT / 花粉暴露室 / 症状誘発の定量化 / 薬物の効果判定 / 季節外誘発 / 花粉曝露室 / 定量的花粉曝露 / 非飛散期誘発試験 / ボランティア / 鼻腔最小面積 / スギ花粉曝露試験 / 非飛散期 / 鼻腔洗浄液 / CysLTs / CysLT1R / IL-4 / IFNγ
Research Abstract

More than 25% of Japanese seems to be suffered on Japanese cedar pollinosis. However, annual pollen dispersion was depend on weather and latitude of the land. So, there are few evidences about the standard drug therapy of Japanese cedar pollinosis.
Our pollen challenge chamber, have to make constant pollen dispersion to the person in the room, was examined for clinical experiment. The temporal and spatial variations of the pollen level in the chamber were small, facilitating stable pollen challenge, and pollinosis symptoms were induced in the volunteers with cedar pollinosis. The challenge chamber may be useful to judge the effects of therapy against pollinosis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (16 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Preliminary study of a challenge test to the patients with Japanese cedar pollinosis using an environmental exposure unit.2010

    • Author(s)
      Ito K, Terada T, Yuki A, Ichihara T, Hyo S, Kawata R, Takenaka H, Amano K, Ishiguro T, Ro T
    • Journal Title

      Auris Nasus Larynx. 237(6)

      Pages: 644-649

    • Related Report
      2010 Final Research Report
  • [Journal Article] Preliminary study of a challenge test to the patients with Japanese cedar pollinosis using an environmental exposure unit.2010

    • Author(s)
      Ito K, Terada T, Yuki A, Ichihara T, Hyo S, Kawata R, Takenaka H, Amano K, Ishiguro T, Ro T.
    • Journal Title

      Auris Nasus Larynx.2

      Volume: 37(6) Pages: 694-649

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気道アレルギーの成立とその制御2009

    • Author(s)
      竹中洋
    • Journal Title

      日耳鼻 112

      Pages: 200-2

    • NAID

      10024836218

    • Related Report
      2010 Final Research Report
  • [Journal Article] Allergic Potency of Japanese cedar pollen Cry j 1 is reduced by a low concentration of hypochlorous acid generated by electolysis.2009

    • Author(s)
      Terada T, Akimoto Y, Hyo S, Suzuki D,Tanaka K, Takenaka H
    • Journal Title

      Allergol Int 58

      Pages: 255-60

    • NAID

      10025109792

    • Related Report
      2010 Final Research Report
  • [Journal Article] A 13-year Study of Japanese Cedar Pollinosis in Japanese Schoolchildren.2008

    • Author(s)
      Ozasa K, Hama T, Dejima K, Watanabe Y, Hyo S,Terada T, Araki N, Takenaka H
    • Journal Title

      Allergol Int 57

      Pages: 175-80

    • NAID

      10021246646

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of local nasal immunotherapy on nasal blockage in pollen-induced allergic rhinitis of Guinea pigs.2008

    • Author(s)
      Nabe T, Kubota K, Mizutani N, Fujii M, Terada T, Takenaka H, Kohno S
    • Journal Title

      Allergol Int 57

      Pages: 419-27

    • NAID

      10025108738

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber Allegology international

    • Author(s)
      Ayumi Yuki, Tetsuya Terada, Takahiro Ichihara, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka
    • Related Report
      2010 Final Research Report
  • [Journal Article] Evaluating the effects of testing period on pollinosis symptoms using an allergen challenge chamber

    • Author(s)
      Ayumi Yuki, Tetsuya Terada, Takahiro Ichihara, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka
    • Journal Title

      Allegology international

      Volume: (in press)

    • NAID

      130004477116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 花粉曝露室の実際ー抗原曝露室で分かったことー2010

    • Author(s)
      寺田哲也、竹中洋
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉曝露室の実際-抗原曝露室で分かったこと-2010

    • Author(s)
      寺田哲也、竹中洋
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] CLINICAL EFFECTS OF MONTELUKAST SODIUM,A LEUKOTRIENE RECEPTOR ANTAGONIST, IN JAPANESE CEDAR POLLINOSIS USING THE ALLERGEN CHALLENGE CHAMBER.2009

    • Author(s)
      Ito K, Takenaka H
    • Organizer
      The XXI World Allergy Congress 2009(世界アレルギー学会)
    • Place of Presentation
      Argentina
    • Year and Date
      2009-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉曝露試験室を用いたモンテルカストのスギ花粉治療に対する検討2009

    • Author(s)
      伊藤加奈子,竹中洋,櫟原崇宏,柚木歩,兵佐和子,寺田哲也
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉曝露試験室を用いたモンテルカストのスギ花粉治療に対する検討2009

    • Author(s)
      伊藤加奈子, 竹中洋, 櫟原崇宏, 柚木歩, 兵佐和子, 寺田哲也
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田ビューホテル(秋田県)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] スギ花粉症に対するモンテルカストの薬効評価-花粉曝露試験室における検討-2009

    • Author(s)
      伊藤加奈子,竹中洋,櫟原崇宏,柚木歩,兵佐和子,寺田哲也
    • Organizer
      第48回日本鼻科学会
    • Place of Presentation
      島根
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] スギ花粉症に対するモンテルカスト(シングレア)の薬効評価―花粉曝露試験室における検討―2009

    • Author(s)
      伊藤加奈子, 竹中洋, 櫟原崇宏, 柚木歩, 兵佐和子, 寺田哲也
    • Organizer
      第48回日本鼻科学会
    • Place of Presentation
      島根県民会館(島根県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] スギ花粉抗原投与によるIgE産生機構-IgE陽性細胞産生について-2009

    • Author(s)
      東野昌子,平野雅予,中西仁美,紀本有実子,桜井幹士,山路純子,窪田隆裕,吉田龍太郎,竹中洋
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉曝露室を用いた薬効評価2009

    • Author(s)
      伊藤加奈子,櫟原崇宏,柚木歩,兵佐和子,寺田哲也,竹中洋
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 気道アレルギーの成立とその制御2009

    • Author(s)
      竹中洋
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 気道アレルギーの成立とその制御2009

    • Author(s)
      竹中洋
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      ザ・プリンスパークタワー東京(東京都)
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 花粉曝露実験室を用いたプランルカストの薬効評価2008

    • Author(s)
      伊藤加奈子,櫟原崇宏,柚木歩,兵佐和子,寺田哲也,竹中洋
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] IgE産生に関する諸問題2008

    • Author(s)
      竹中洋
    • Organizer
      第1回旭川アレルギー性鼻炎セミナー
    • Place of Presentation
      北海道
    • Year and Date
      2008-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] スギ花粉特異的IgEの産生機構-スギ花粉投与部位による相違2008

    • Author(s)
      桜井幹士,吉田龍太郎,紀本有実子,李昊哲,山口智子,東野昌子,竹中洋
    • Organizer
      第109回日本耳鼻咽喉科学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 花粉曝露実験室を用いたスギ花粉症に関する検討2008

    • Author(s)
      柚木歩,兵佐和子,伊藤加奈子,寺田哲也,竹中洋
    • Organizer
      第109回日本耳鼻咽喉科学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Epidemiological Study of Japanese Cedar Pollinosis in Japanese.2008

    • Author(s)
      竹中洋
    • Organizer
      The 35^<th> Congress of the Korean Rhinologic Society
    • Place of Presentation
      Korea
    • Year and Date
      2008-03-09
    • Related Report
      2010 Final Research Report
  • [Book] 気道アレルギーの成立とその制御2009

    • Author(s)
      竹中洋著
    • Publisher
      中西印刷株式会社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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