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Role of medullary interneurons in swallowing pattern generation

Research Project

Project/Area Number 20592022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

UMEZAKI Toshiro  Kyushu University, 大学病院, 講師 (80223600)

Co-Investigator(Kenkyū-buntansha) ADACHI Kazuo  九州大学, 大学病院, 助教 (90380386)
NAKAZAWA Ken  千葉大学, 医学系研究院, 講師 (10312943)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords嚥下 / fictive swallowing model / モルモット / ニューロビオチン / 孤束核 / 嚥下関連ニューロン / 軸索投射 / 延髄網様体 / 上喉頭神経 / neurobiotin / 疑核 / HRP / フェレット / fictive model
Research Abstract

To reveal the medullary neuronal network of the swallowing central pattern generator (CPG), we examined the cytoarchitecture of the swallowing CPG and axonal projections of its individual neurons by extracellular recording and juxtacellular labeling of swallowing-related neurons (SRNs) in the medulla in urethane-anesthetized and paralyzed guinea pigs. The SRNs in and around the NTS had axons projecting to the NTS, RF, nucleus ambiguus, nucleus hypoglossus, and dorsalmotor nucleus of the vagus on the ipsilateral side. These findings show anatomic substrates for the neuronal network of the CPG for swallowing, which consists of complex neuronal connections among SRNs in the NTS, RF, and motor nuclei.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (47 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 24 results) Presentation (17 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs.2011

    • Author(s)
      Sugiyama y, Umezaki T, et.al.
    • Journal Title

      Journal of Comparative Neurology in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs.2011

    • Author(s)
      Sugiyama y, Umezaki T, et.al
    • Journal Title

      Journal of Comparative Neurology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in the hyoepiglottic ligament : functional implications based on histopathologic study.2010

    • Author(s)
      Sawatsubashi M, Umezaki T, Kusano K, et al.
    • Journal Title

      American Journal of Otolaryngology 31

      Pages: 448-452

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 嚥下圧と嚥下内視鏡検査同時記録による嚥下動態解析の試み2010

    • Author(s)
      安達一雄、梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 229-234

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小脳髄膜腫術後の嚥下障害に対し脂肪注入と軟口蓋挙上装置を併用し経口摂取が可能となった1例2010

    • Author(s)
      山野貴史, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 151-156

    • NAID

      130004555479

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 液体とゼリー嚥下時の咽頭期嚥下動態の相違LEDTによる検討2010

    • Author(s)
      宮地英彰, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 138-144

    • NAID

      130004555477

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 物性の違いとリクライニング位による嚥下動態の検討2010

    • Author(s)
      山口優実, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 133-137

    • NAID

      130004555476

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 竹節状声帯2010

    • Author(s)
      梅崎俊郎
    • Journal Title

      耳鼻途臨床 56巻

      Pages: 234-236

    • NAID

      130004555451

    • Related Report
      2010 Final Research Report
  • [Journal Article] 喉頭狭窄および後部声門癒着症例における特性T-チューブの調整についての検討2010

    • Author(s)
      安達一雄, 梅崎俊郎, 小宗静男
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 221-227

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 当科における挿管性披裂軟骨脱臼症例の検討2010

    • Author(s)
      山野貴史, 宮城司道, 樋口仁美, 梅崎俊郎,中川尚志
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 206-211

    • NAID

      130004555448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 緊急気管切開術を要したポリープ様声帯の1例2010

    • Author(s)
      梅野好啓, 門田英輝, 安達一雄, 井口貴史, 福島淳一, 梅崎俊郎
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 19-23

    • NAID

      130004862248

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in the hyoepiglottic ligament : functional implications based on histopathologic study.2010

    • Author(s)
      Sawatsubashi M, Umezaki T, Kusano K, et al
    • Journal Title

      American Journal of Otolaryngology

      Volume: 31 Pages: 448-452

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 嚥下圧と嚥下内視鏡検査同時記録による嚥下動態解析の試み 声門閉鎖不全症例について2010

    • Author(s)
      安達一雄、梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 229-234

    • NAID

      130004555488

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小脳髄膜腫術後の嚥下障害に対し脂肪注入と軟口蓋挙上装置を併用し経口摂取が可能となった1例2010

    • Author(s)
      山野貴史, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 151-156

    • NAID

      130004555479

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 液体とゼリー嚥下時の咽頭期嚥下動態の相違LEDTによる検討2010

    • Author(s)
      宮地英彰, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 138-144

    • NAID

      130004555477

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 物性の違いとリクライニング位による嚥下動態の検討2010

    • Author(s)
      山口優実, 梅崎俊郎, 他
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 133-137

    • NAID

      130004555476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 竹節状声帯2010

    • Author(s)
      梅崎俊郎
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 234-236

    • NAID

      130004555451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喉頭狭窄および後部声門癒着症例における特性T-チューブの調整についての検討2010

    • Author(s)
      安達一雄, 梅崎俊郎, 小宗静男
    • Journal Title

      耳鼻と臨床56巻

      Volume: 56 Pages: 221-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 当科における挿管性披裂軟骨脱臼症例の検討2010

    • Author(s)
      山野貴史, 宮城司道, 樋口仁美, 梅崎俊郎, 中川尚志
    • Journal Title

      耳鼻と臨床

      Volume: 56 Pages: 206-211

    • NAID

      130004555448

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 緊急気管切開術を要したポリープ様声帯の1例2010

    • Author(s)
      梅野好啓, 門田英輝, 安達一雄, 井口貴史, 福島淳一, 梅崎俊郎
    • Journal Title

      耳鼻と臨床56巻

      Volume: 56 Pages: 19-23

    • NAID

      130004862248

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in the hyoepiglottic ligament : functional impheations based on histopathologic study2009

    • Author(s)
      Sawatsubashi M, Umezaki T, Kusano K., et al
    • Journal Title

      American Journal of Otolaryngology 30

      Pages: 5-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 嚥下機能の変動を観察し得た抗Hu抗体陽性の傍腫瘍性神経症候群の1例2009

    • Author(s)
      宮地英彰, 梅崎俊郎, 安達一雄, 他
    • Journal Title

      耳鼻と臨床 55

    • NAID

      130004555428

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児声門・声門下狭窄症例の治療後の音声についての検討2009

    • Author(s)
      安達一雄, 梅崎俊郎, 片岡和子, 他
    • Journal Title

      耳鼻と臨床 55

      Pages: 205-209

    • NAID

      130004555401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      梅崎俊郎
    • Journal Title

      消化器外科ベッドサイド処置&ケア((株)メディカ出版(大阪))

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 逆流性食道炎2009

    • Author(s)
      梅崎俊郎
    • Journal Title

      ENTONI 100

      Pages: 141-146

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 小児難治性誤嚥に対する喉頭気管分離術2008

    • Author(s)
      松原尚子, 梅崎俊郎, 安達一雄, その, 他
    • Journal Title

      小児耳鼻咽喉科 29巻

      Pages: 243-246

    • NAID

      10024844419

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 当科における声帯内脂肪注入術の長期予後についての検討2008

    • Author(s)
      安達一雄, 梅崎俊郎, その, 他
    • Journal Title

      耳鼻と臨床 54巻

      Pages: 82-88

    • NAID

      130004405130

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム「嚥下障害診療の問題点-学際的な立場から-」嚥下障害の診断における問題点2010

    • Author(s)
      梅崎俊郎
    • Organizer
      日本気管食道科学会
    • Place of Presentation
      大分.招待
    • Year and Date
      2010-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「嚥下障害診療の問題点-学際的な立場から-」嚥下障害の診断における問題点2010

    • Author(s)
      梅崎俊郎
    • Organizer
      日本気管食道科学会
    • Place of Presentation
      大分
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Management of the anterior commissure in laryngomicrosurgery by fibrin coating method -A simple technique to prevent glottal web in laryngomicrosurgery-2010

    • Author(s)
      Umezaki, T., et al.
    • Organizer
      AAO-HNSF annual meeting
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Management of the anterior commissure in laryngomicrosurgery by fibrin coating method -A simple technique to prevent glottal web in laryngomicrosurgery-2010

    • Author(s)
      Umezaki, T, et al
    • Organizer
      AAO-HNSF annual meeting
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 嚥下における披裂喉頭蓋筋の役割-組織学的検討-2010

    • Author(s)
      澤津橋基広、梅崎俊郎, 他
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳磁図(MEG)を用いた咽喉頭感覚の検討2010

    • Author(s)
      宮地英彰, 梅崎俊郎, 他
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 公開パネル:嚥下障害患者の外来診療-問題点と工夫-2010

    • Author(s)
      梅崎俊郎
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嚥下圧と嚥下内視鏡同時記録による嚥下動態解析の試み-声門閉鎖不全症例について2010

    • Author(s)
      安達一雄, 梅崎俊郎, 他
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 喉頭前庭閉鎖のメカニズム-組織学的考察-2010

    • Author(s)
      澤津橋基広, 梅崎俊郎, 他
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] モルモットにおける嚥下関連ニューロンの活動および投射様式2010

    • Author(s)
      杉山庸一郎, 梅崎俊郎, 他
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] パネルディスカッション 嚥下障害に対する手術の難点2010

    • Author(s)
      梅崎俊郎
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ランチョンセミナー「喉頭レーザー手術」2009

    • Author(s)
      梅崎俊郎
    • Organizer
      日本音声言語医学会
    • Place of Presentation
      福島
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嚥下障害の治療-特に外科的治療について-2009

    • Author(s)
      梅崎俊郎
    • Organizer
      日本口腔咽頭科学会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ビデオセミナー「音声外科-甲状軟骨形成術I型のコツ」2009

    • Author(s)
      梅崎俊郎
    • Organizer
      日本耳鼻咽喉科臨床学会
    • Place of Presentation
      旭川
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嚥下の研究~気が付けば4半世紀~2009

    • Author(s)
      梅崎俊郎
    • Organizer
      名古屋嚥下懇話会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-04-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] うま味による嚥下調節の脳内機構2009

    • Author(s)
      梅崎俊郎
    • Organizer
      日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム「食情報調節の仕組み」2. 味覚と嚥下反射2008

    • Author(s)
      梅崎俊郎
    • Organizer
      日本味と匂い学会
    • Place of Presentation
      富山市
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Book] 喉頭(声門下)狭窄(カニューレ抜去困難症を含む).(「今日の耳鼻咽喉科頭頸部外科治療指針第3版」)2008

    • Author(s)
      梅崎俊郎
    • Publisher
      医学書院(東京)
    • Related Report
      2010 Final Research Report
  • [Book] 今日の耳鼻咽喉科頭頸部外科治療指針 第3版2008

    • Author(s)
      梅崎俊郎
    • Total Pages
      663
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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