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Tissue engineering for development of new artificial trachea, and elucidation of mechanism on tracheal epithelial regeneration.

Research Project

Project/Area Number 20592024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University

Principal Investigator

TADA Yasuhiro  Fukushima Medical University, 医学部, 講師 (70363760)

Co-Investigator(Kenkyū-buntansha) 竹澤 俊明  独立行政法人農業生物資源研究所, 遺伝子組換え家畜研究センター, 主任研究員 (50301297)
横山 秀二  福島県立医科大学, 医学部, 助教 (80381408)
三蒲 智広 (三浦 智広)  福島県立医科大学, 医学部, 助教 (00423806)
Co-Investigator(Renkei-kenkyūsha) TAKEZAWA Toshiaki  独立行政法人農業生物資源研究所, 遺伝子組み換え家畜研究センター, 主任研究員 (50301297)
YOKOYAMA Shuji  福島県立医科大学, 医学部, 助教 (80381408)
MIURA Tomohiro  福島県立医科大学, 医学部, 助教 (00423806)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords気管食道学 / 再生 / 気管 / vitrigel / b-FGF / 気管上皮 / collagen / コラーゲン / bi-potential scaffold
Research Abstract

Our technique for tracheal reconstruction using vitrigel collagen-sponge scaffolds with b-FGF application affords a feasible approach for accelerating regeneration of the intra-luminal surface and subepithelial layer of the regenerated tracheal tissue.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results)

  • [Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.2010

    • Author(s)
      Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T, Omori K
    • Journal Title

      Biomaterials 31(18)

      Pages: 4855-4863

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bio-engineered scaffold with fibroblast for tracheal regeneration in a rabbit model.2010

    • Author(s)
      Okano W, Nomoto Y, Kobayashi K, Miyake M, Suzuki T, Tada Y, Nakamura T, Watanabe M, Omori K
    • Journal Title

      Inflammation and Regeneration 30

      Pages: 34-39

    • NAID

      10026094188

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis.2010

    • Author(s)
      Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M
    • Journal Title

      Blood 115(20)

      Pages: 4138-4147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bio-engineered scaffold with fibroblast for tracheal regeneration in a rabbit model2010

    • Author(s)
      Okano W, Nomoto Y, Kobayashi K, Miyake M, Suzuki T, Tada Y, Nakamura T, Watanabe M, Omori K
    • Journal Title

      Inflammation and Regeneration

      Volume: Vol.30 Pages: 34-39

    • NAID

      10026094188

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.2010

    • Author(s)
      Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T, Omori K
    • Journal Title

      Biomaterials

      Volume: 31(18) Pages: 4855-4863

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-engineered scaffold with fibroblast for tracheal regeneration in a rabbit model2010

    • Author(s)
      Okano W, Tada Y, et al
    • Journal Title

      炎症再生学会 Vol.30

      Pages: 34-39

    • NAID

      10026094188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of Tracheal Epithelium Utilizing a Novel Bi-potential Collagen Scaffold.2008

    • Author(s)
      Tada Yasuhiro, Suzuki Teruhisa, Takezawa Toshiaki, Nomoto Yukio, Kobayashi Ken, Nakamura Tatuo, Omori Koichi
    • Journal Title

      Ann Otol Rhinol Laryngol 177(5)

      Pages: 359-365

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of Tracheal Epithelium Utilizing a Novel Bi-potential Collagen Scaffold2008

    • Author(s)
      Yasuhiro Tada, Teruhisa Suzuki, Toshiaki Takezawa, Yukio Nomoto, Ken Kobayashi, Tatuo Nakamura, Koichi Omori
    • Journal Title

      Ann Otol Rhinol Laryngol. 117(5)

      Pages: 359-365

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Quantitative Assessment of Regenerated Tracheal Epithelium by Collagen Vitrigel Scaffold.2010

    • Author(s)
      Tada Yasuhiro, et.al.
    • Organizer
      18^<th> Annual Meeting of the American Broncho-Esophagological Association
    • Place of Presentation
      アメリカ(ラスベガス)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantitative Assessment of Regenerated Tracheal Epithelium by Collagen Vitrigel Scaffold2010

    • Author(s)
      Yasuhiro Tada, et. al.
    • Organizer
      Annual Meeting of the American Broncho-Esophagological Association
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] コラーゲンビトリゲル薄膜を培養担体に用いた培養角膜モデルの開発状況とその特徴2010

    • Author(s)
      多田靖宏、山口宏之
    • Organizer
      日本動物実験代替法学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ビトリゲルとスポンジのハイブリッド型コラーゲン材料を用いた気管の再生:公開シンポジウム2009

    • Author(s)
      多田靖宏
    • Organizer
      3次元培養担体として利用が進むコラーゲンビトリゲル研究の現状と展望
    • Place of Presentation
      東京
    • Year and Date
      2009-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] ビトリゲルとスポンジのハイブリッド型コラーゲン材料を用いた気管の再生2009

    • Author(s)
      多田靖宏
    • Organizer
      公開シンポジウム:3次元培養担体として利用が進むコラーゲンビトリゲル研究の現状と展望
    • Place of Presentation
      東京都
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気道の再生医療:臨床応用から基礎実験へのフィードバック2009

    • Author(s)
      多田靖宏
    • Organizer
      第105回福島県地方部会
    • Place of Presentation
      福島市
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of Bi-potential scaffold for regeneration of the trachea: In vitro and In vivo studies.2008

    • Author(s)
      Tada Yasuhiro, Takezawa Toshiaki, Suzuki Teruhisa, Kobayashi Ken, Nakamura Tatsuo, Omori Koichi
    • Organizer
      111^<th> The Triological Society
    • Place of Presentation
      アメリカ(オーランド)
    • Year and Date
      2008-05-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Evaluation of Bi-potential scaffold for regeneration of the trachea : In vitro and In vivo studies2008

    • Author(s)
      YASUHIRO TADA, TOSHIAKITAKEZAWA, TERUHISA SUZUKI, KEN KOBAYASHI, TATSUONAKAMURA, KOICHI OMORI
    • Organizer
      Combined Otolarymgology Ppring Meeting
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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