The role of Activin-Follistatin System in Diabetic Retinopathy
| Project/Area Number |
20592032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gunma University |
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Principal Investigator |
KISHI Shouji Gunma University, 大学院・医学系研究科, 教授 (30125843)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アクチビン / 血管新生 / 糖尿病網膜症 |
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| Research Abstract |
An Activin concentration in the vitreous of Proliferative Diabetic Retinopathy was higher than that of Simple Diabetic Retinopathy. Activin inhibited tubulogenesis of HUVECs even in the presence of VEGF. Follistatin induced tubulogenesis of HUVECs. Injection of Activin in the vitreous decreased the size of Laser-induced mouse choroidal neovascularization.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Three-dimensional profile of macular retinal thickness in normal Japanese eyes.2010
Author(s)
Ooto S, Hangai M, Sakamoto A, Tomidokoro A, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Takeda H, Sugiyama K, Saito H, Iwase A, Yoshimura N
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Journal Title
Invest Ophthalmol Vis Sci 51(1)
Pages: 465-73
Related Report
Peer Reviewed
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[Journal Article] Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes.2010
Author(s)
Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N
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Journal Title
Arch Ophthalmol 128(11)
Pages: 1420-6
Related Report
Peer Reviewed
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[Journal Article] EXTEND-I Study Group(Acta Ophthalmol)2010
Author(s)
Tano Y, Ohji M
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Journal Title
EXTEND-I : safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. 88(3)
Pages: 309-16
Related Report
Peer Reviewed
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[Journal Article] ベバシズマブ硝子体内投与により退縮した点状脈絡膜内層症に併発した脈絡膜新生血管2010
Author(s)
浅原大典,向井亮,佐藤拓,渡辺五郎,堀内康史,森本雅裕,松本英孝,高橋牧,村上結香,袖山博隆,岸章治
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Related Report
Peer Reviewed
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