The role of Activin-Follistatin System in Diabetic Retinopathy

• Project/Area Number: 20592032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Gunma University
• Principal Investigator: KISHI Shouji Gunma University, 大学院・医学系研究科, 教授 (30125843)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アクチビン / 血管新生 / 糖尿病網膜症

Research Abstract

An Activin concentration in the vitreous of Proliferative Diabetic Retinopathy was higher than that of Simple Diabetic Retinopathy. Activin inhibited tubulogenesis of HUVECs even in the presence of VEGF. Follistatin induced tubulogenesis of HUVECs. Injection of Activin in the vitreous decreased the size of Laser-induced mouse choroidal neovascularization.

Research Products

• [Journal Article] Improved visualization of Henle fiber layer by changing the measurement beam angle on optical coherence tomography. (2011)
  • Author(s): Otani T, Yamaguchi Y, Kishi S
  • Journal Title: Retina 31 Pages: 497-501
  • Peer Reviewed
• [Journal Article] Restored photoreceptor outer segment in commotio retinae. (2011)
  • Author(s): Itakura H, Kishi S
  • Journal Title: Ophthalmic Surg Lasers Imaging. 3
  • Peer Reviewed
• [Journal Article] Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy. (2011)
  • Author(s): Matsumoto H, Kishi S, Sato T, Mukai R
  • Journal Title: Am J Ophthalmol 151(4) Pages: 617-623
  • Peer Reviewed
• [Journal Article] Three-dimensional profile of macular retinal thickness in normal Japanese eyes. (2010)
  • Author(s): Ooto S, Hangai M, Sakamoto A, Tomidokoro A, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Takeda H, Sugiyama K, Saito H, Iwase A, Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci 51(1) Pages: 465-73
  • Peer Reviewed
• [Journal Article] Restoration of photoreceptor outer segment after vitrectomy for retinal detachment. (2010)
  • Author(s): Shimoda Y, Sano M, Hashimoto H, Yokota Y, Kishi S
  • Journal Title: Am J Ophthalmol 149(2) Pages: 284-90
  • Peer Reviewed
• [Journal Article] Tomographic features of intraretinal neovascularization in retinal angiomatous proliferation. (2010)
  • Author(s): Matsumoto H, Sato T, Kishi S
  • Journal Title: Retina 30(3) Pages: 425-30
  • Peer Reviewed
• [Journal Article] Correlation between visual acuity and foveal microstructural changes in diabetic macular edema. (2010)
  • Author(s): Otani T, Yamaguchi Y, Kishi S
  • Journal Title: Retina 30(5) Pages: 774-80
  • Peer Reviewed
• [Journal Article] Protective Effect of Intravitreal Bevacizumab and Sub-Tenon Triamcinolone Acetonide against Occlusion of Choriocapillaris Induced by Photodynamic Therapy. (2010)
  • Author(s): Mukai R, Kishi S, Sato T, Watanabe G, Matsumoto H
  • Journal Title: Ophthalmologica 224(5) Pages: 267-273
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for age-related macular degeneration with good visual acuity. (2010)
  • Author(s): Takahashi M, Sato T, Kishi S
  • Journal Title: Jpn J Ophthalmol 54(6) Pages: 565-70
  • NAID: 10027666291
  • Peer Reviewed
• [Journal Article] Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes. (2010)
  • Author(s): Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N
  • Journal Title: Arch Ophthalmol 128(11) Pages: 1420-6
  • Peer Reviewed
• [Journal Article] Photoreceptor damage after prolonged gazing at a computer game display. (2010)
  • Author(s): Kishi S, Li D, Takahashi M, Hashimoto H
  • Journal Title: Jpn J Ophthalmol 54(5) Pages: 514-6
  • NAID: 10027666104
  • Peer Reviewed
• [Journal Article] Inner neural retina loss in central retinal artery occlusion. (2010)
  • Author(s): Ikeda F, Kishi S
  • Journal Title: Jpn J Ophthalmol 54(5) Pages: 423-9
  • NAID: 10027665737
  • Peer Reviewed
• [Journal Article] Combined photodynamic therapy with verteporfin and intravitreal bevacizumab for polypoidal choroidal vasculopathy. (2010)
  • Author(s): Sato T, Kishi S, Matsumoto H, Mukai R
  • Journal Title: Am J Ophthalmol 149(6) Pages: 947-954
  • Peer Reviewed
• [Journal Article] Protective effect of intravitreal bevacizumab and sub-tenon triamcinolone acetonide against occlusion of choriocapillaris induced by photodynamic therapy. (2010)
  • Author(s): Mukai R, Kishi S, Sato T, Watanabe G, Matsumoto H
  • Journal Title: Ophthalmologica 224(5) Pages: 267-73
  • Peer Reviewed
• [Journal Article] EXTEND-I Study Group(Acta Ophthalmol) (2010)
  • Author(s): Tano Y, Ohji M
  • Journal Title: EXTEND-I : safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. 88(3) Pages: 309-16
  • Peer Reviewed
• [Journal Article] 網膜細動脈瘤へのベバシズマブ硝子体内注射の効果 (2010)
  • Author(s): 鈴木康太,横田幸大,橋本英明,下田幸紀,岸章治
  • Journal Title: 臨床眼科 64巻9号 Pages: 1561-1566
  • Peer Reviewed
• [Journal Article] ベバシズマブ硝子体内投与により退縮した点状脈絡膜内層症に併発した脈絡膜新生血管 (2010)
  • Author(s): 浅原大典,向井亮,佐藤拓,渡辺五郎,堀内康史,森本雅裕,松本英孝,高橋牧,村上結香,袖山博隆,岸章治
  • Journal Title: 臨床眼 64巻5号 Pages: 699-706
  • Peer Reviewed
• [Journal Article] Identification of differentially express genes induced during the proliferative response of the liver induced by follistatin. (2009)
  • Author(s): Medina J., Yamada S., Kojima I.
  • Journal Title: Endocrine J. 56 Pages: 1067-1077
  • Peer Reviewed
• [Journal Article] Restored photoreceptor outer segment and visual recovery after macular hole closure. (2009)
  • Author(s): Sano M, Shimoda Y, Hashimoto H, Kishi S
  • Journal Title: Am J Ophthalmol 147(2) Pages: 313-318
  • Peer Reviewed
• [Journal Article] Foveal thickness can predict visual outcome in patients with persistent central serous chorioretinopathy. (2009)
  • Author(s): Furuta M, Iida T, Kishi S
  • Journal Title: Ophthalmologica 223(1) Pages: 28-31
  • Peer Reviewed
• [Journal Article] Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome. (2009)
  • Author(s): Li D, Kishi S
  • Journal Title: Ophthalmology 116(4) Pages: 762-70
  • Peer Reviewed
• [Journal Article] Decreased vitreal hyaluronan levels with aging. (2009)
  • Author(s): Itakura H, Kishi S, Kotajima N, Murakami M
  • Journal Title: Ophthalmologica 223(1) Pages: 32-5
  • Peer Reviewed
• [Journal Article] Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy. (2009)
  • Author(s): Matsumoto H, Sato T, Kishi S
  • Journal Title: Am J Ophthalmol 148(1) Pages: 105-10
  • Peer Reviewed
• [Journal Article] Intravitreal injection of 0.3ml of SF6 gas for persistent subfoveal fluid after scleral buckling for rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol (2009)
  • Author(s): Itakura H, Kishi S
  • Journal Title: 247(8) Pages: 1147-50
  • Peer Reviewed
• [Journal Article] Effect of Intravitreal Injection of High-Dose Bevacizumab in Monkey Eyes. (2009)
  • Author(s): Sakurai K, Akiyama H, Shimoda Y, Yoshida I, Kurabayashi M, Kishi S
  • Journal Title: Invest Ophthalmol Vis Sci 50(10) Pages: 4905-16
  • Peer Reviewed
• [Journal Article] Shortening of the rod outer segment in Oguchi disease. (2009)
  • Author(s): Hashimoto H, Kishi S
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247(11) Pages: 1561-3
  • Peer Reviewed
• [Journal Article] Surgically induced posterior vitreous detachment by tearing the premacular vitreous cortex. (2009)
  • Author(s): Otani T, Kishi S
  • Journal Title: Retina 29(8) Pages: 1193-4
  • Peer Reviewed
• [Journal Article] Resolution of retinoschisis after vitreous surgery in X-linked retinoschisis. (2008)
  • Author(s): Ikeda F, Iida T, Kishi S
  • Journal Title: Ophthalmology 115(4) Pages: 718-722
  • Peer Reviewed
• [Journal Article] Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy. (2008)
  • Author(s): Shimoda Y, Hamano R, Ishihara K, Shimoda N, Hagimura N, Akiyama H, Kishi S, Kaneko A
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246(4) Pages: 501-8
  • Peer Reviewed
• [Journal Article] Elongation of photoreceptor outer segment in central serous chorioretinopathy. (2008)
  • Author(s): Matsumoto H, Kishi S, Otani T, Sato T
  • Journal Title: Am J Ophthalmol 145(1) Pages: 162-168
  • Peer Reviewed
• [Journal Article] Efficacy and retention times of intravitreal triamcinolone acetonide for macular edema. (2008)
  • Author(s): Kogure A, Ohkoshi K, Kogure S, Yamaguchi T, Kishi S
  • Journal Title: Jpn J Ophthalmol 52(2) Pages: 122-6
  • NAID: 10024153842
  • Peer Reviewed
• [Journal Article] Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon. (2008)
  • Author(s): Watanabe G, Fujii H, Kishi S
  • Journal Title: Jpn J Ophthalmol 52(3) Pages: 175-81
  • NAID: 10024153978
  • Peer Reviewed
• [Journal Article] Aging changes of vitreomacular interface.
  • Author(s): Itakura H, Kishi S
  • Journal Title: Retina. (inpress)
  • Peer Reviewed
• [Presentation] The role of Activin A in Angiogenesis (2011)
  • Author(s): 前嶋京子、小島至、岸章治
  • Organizer: ARVO 2011 annual meeting
  • Place of Presentation: フォートローダーデール国際会議場、(フロリダ、アメリカ)
  • Year and Date: 2011-05-04
• [Presentation] 実験的脈絡膜新生血管とアクチビン (2009)
  • Author(s): 吉田いづみ、前嶋京子、小島至、岸章治
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-17
• [Presentation] 実験的脈絡膜新生血管とアクチビン (2009)
  • Author(s): 吉田いづみ
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2009-04-17
• [Presentation] アクチビン及びフォリスタチンによる管腔形成作用 (2008)
  • Author(s): 前嶋京子、小島至、岸章治
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2008-04-18
• [Presentation] アクチビン及びフォリスタチンによる管腔形成作用 (2008)
  • Author(s): 前嶋京子
  • Organizer: 第112回日本眼科学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18