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The role of Activin-Follistatin System in Diabetic Retinopathy

Research Project

Project/Area Number 20592032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionGunma University

Principal Investigator

KISHI Shouji  Gunma University, 大学院・医学系研究科, 教授 (30125843)

Co-Investigator(Kenkyū-buntansha) KOJIMA Itaru  群馬大学, 生体調節研究所, 教授 (60143492)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアクチビン / 血管新生 / 糖尿病網膜症
Research Abstract

An Activin concentration in the vitreous of Proliferative Diabetic Retinopathy was higher than that of Simple Diabetic Retinopathy. Activin inhibited tubulogenesis of HUVECs even in the presence of VEGF. Follistatin induced tubulogenesis of HUVECs. Injection of Activin in the vitreous decreased the size of Laser-induced mouse choroidal neovascularization.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 2008 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (5 results)

  • [Journal Article] Improved visualization of Henle fiber layer by changing the measurement beam angle on optical coherence tomography.2011

    • Author(s)
      Otani T, Yamaguchi Y, Kishi S
    • Journal Title

      Retina 31

      Pages: 497-501

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restored photoreceptor outer segment in commotio retinae.2011

    • Author(s)
      Itakura H, Kishi S
    • Journal Title

      Ophthalmic Surg Lasers Imaging. 3

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy.2011

    • Author(s)
      Matsumoto H, Kishi S, Sato T, Mukai R
    • Journal Title

      Am J Ophthalmol 151(4)

      Pages: 617-623

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional profile of macular retinal thickness in normal Japanese eyes.2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tomidokoro A, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Takeda H, Sugiyama K, Saito H, Iwase A, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci 51(1)

      Pages: 465-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of photoreceptor outer segment after vitrectomy for retinal detachment.2010

    • Author(s)
      Shimoda Y, Sano M, Hashimoto H, Yokota Y, Kishi S
    • Journal Title

      Am J Ophthalmol 149(2)

      Pages: 284-90

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tomographic features of intraretinal neovascularization in retinal angiomatous proliferation.2010

    • Author(s)
      Matsumoto H, Sato T, Kishi S
    • Journal Title

      Retina 30(3)

      Pages: 425-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between visual acuity and foveal microstructural changes in diabetic macular edema.2010

    • Author(s)
      Otani T, Yamaguchi Y, Kishi S
    • Journal Title

      Retina 30(5)

      Pages: 774-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective Effect of Intravitreal Bevacizumab and Sub-Tenon Triamcinolone Acetonide against Occlusion of Choriocapillaris Induced by Photodynamic Therapy.2010

    • Author(s)
      Mukai R, Kishi S, Sato T, Watanabe G, Matsumoto H
    • Journal Title

      Ophthalmologica 224(5)

      Pages: 267-273

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for age-related macular degeneration with good visual acuity.2010

    • Author(s)
      Takahashi M, Sato T, Kishi S
    • Journal Title

      Jpn J Ophthalmol 54(6)

      Pages: 565-70

    • NAID

      10027666291

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes.2010

    • Author(s)
      Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N
    • Journal Title

      Arch Ophthalmol 128(11)

      Pages: 1420-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoreceptor damage after prolonged gazing at a computer game display.2010

    • Author(s)
      Kishi S, Li D, Takahashi M, Hashimoto H
    • Journal Title

      Jpn J Ophthalmol 54(5)

      Pages: 514-6

    • NAID

      10027666104

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inner neural retina loss in central retinal artery occlusion.2010

    • Author(s)
      Ikeda F, Kishi S
    • Journal Title

      Jpn J Ophthalmol 54(5)

      Pages: 423-9

    • NAID

      10027665737

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined photodynamic therapy with verteporfin and intravitreal bevacizumab for polypoidal choroidal vasculopathy.2010

    • Author(s)
      Sato T, Kishi S, Matsumoto H, Mukai R
    • Journal Title

      Am J Ophthalmol 149(6)

      Pages: 947-954

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of intravitreal bevacizumab and sub-tenon triamcinolone acetonide against occlusion of choriocapillaris induced by photodynamic therapy.2010

    • Author(s)
      Mukai R, Kishi S, Sato T, Watanabe G, Matsumoto H
    • Journal Title

      Ophthalmologica 224(5)

      Pages: 267-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] EXTEND-I Study Group(Acta Ophthalmol)2010

    • Author(s)
      Tano Y, Ohji M
    • Journal Title

      EXTEND-I : safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. 88(3)

      Pages: 309-16

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 網膜細動脈瘤へのベバシズマブ硝子体内注射の効果2010

    • Author(s)
      鈴木康太,横田幸大,橋本英明,下田幸紀,岸章治
    • Journal Title

      臨床眼科 64巻9号

      Pages: 1561-1566

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ベバシズマブ硝子体内投与により退縮した点状脈絡膜内層症に併発した脈絡膜新生血管2010

    • Author(s)
      浅原大典,向井亮,佐藤拓,渡辺五郎,堀内康史,森本雅裕,松本英孝,高橋牧,村上結香,袖山博隆,岸章治
    • Journal Title

      臨床眼 64巻5号

      Pages: 699-706

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of differentially express genes induced during the proliferative response of the liver induced by follistatin.2009

    • Author(s)
      Medina J., Yamada S., Kojima I.
    • Journal Title

      Endocrine J. 56

      Pages: 1067-1077

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restored photoreceptor outer segment and visual recovery after macular hole closure.2009

    • Author(s)
      Sano M, Shimoda Y, Hashimoto H, Kishi S
    • Journal Title

      Am J Ophthalmol 147(2)

      Pages: 313-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Foveal thickness can predict visual outcome in patients with persistent central serous chorioretinopathy.2009

    • Author(s)
      Furuta M, Iida T, Kishi S
    • Journal Title

      Ophthalmologica 223(1)

      Pages: 28-31

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome.2009

    • Author(s)
      Li D, Kishi S
    • Journal Title

      Ophthalmology 116(4)

      Pages: 762-70

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased vitreal hyaluronan levels with aging.2009

    • Author(s)
      Itakura H, Kishi S, Kotajima N, Murakami M
    • Journal Title

      Ophthalmologica 223(1)

      Pages: 32-5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy.2009

    • Author(s)
      Matsumoto H, Sato T, Kishi S
    • Journal Title

      Am J Ophthalmol 148(1)

      Pages: 105-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of 0.3ml of SF6 gas for persistent subfoveal fluid after scleral buckling for rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol2009

    • Author(s)
      Itakura H, Kishi S
    • Journal Title

      247(8)

      Pages: 1147-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Intravitreal Injection of High-Dose Bevacizumab in Monkey Eyes.2009

    • Author(s)
      Sakurai K, Akiyama H, Shimoda Y, Yoshida I, Kurabayashi M, Kishi S
    • Journal Title

      Invest Ophthalmol Vis Sci 50(10)

      Pages: 4905-16

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shortening of the rod outer segment in Oguchi disease.2009

    • Author(s)
      Hashimoto H, Kishi S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 247(11)

      Pages: 1561-3

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgically induced posterior vitreous detachment by tearing the premacular vitreous cortex.2009

    • Author(s)
      Otani T, Kishi S
    • Journal Title

      Retina 29(8)

      Pages: 1193-4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resolution of retinoschisis after vitreous surgery in X-linked retinoschisis.2008

    • Author(s)
      Ikeda F, Iida T, Kishi S
    • Journal Title

      Ophthalmology 115(4)

      Pages: 718-722

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy.2008

    • Author(s)
      Shimoda Y, Hamano R, Ishihara K, Shimoda N, Hagimura N, Akiyama H, Kishi S, Kaneko A
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 246(4)

      Pages: 501-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elongation of photoreceptor outer segment in central serous chorioretinopathy.2008

    • Author(s)
      Matsumoto H, Kishi S, Otani T, Sato T
    • Journal Title

      Am J Ophthalmol 145(1)

      Pages: 162-168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and retention times of intravitreal triamcinolone acetonide for macular edema.2008

    • Author(s)
      Kogure A, Ohkoshi K, Kogure S, Yamaguchi T, Kishi S
    • Journal Title

      Jpn J Ophthalmol 52(2)

      Pages: 122-6

    • NAID

      10024153842

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon.2008

    • Author(s)
      Watanabe G, Fujii H, Kishi S
    • Journal Title

      Jpn J Ophthalmol 52(3)

      Pages: 175-81

    • NAID

      10024153978

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging changes of vitreomacular interface.

    • Author(s)
      Itakura H, Kishi S
    • Journal Title

      Retina. (inpress)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] The role of Activin A in Angiogenesis2011

    • Author(s)
      前嶋京子、小島至、岸章治
    • Organizer
      ARVO 2011 annual meeting
    • Place of Presentation
      フォートローダーデール国際会議場、(フロリダ、アメリカ)
    • Year and Date
      2011-05-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 実験的脈絡膜新生血管とアクチビン2009

    • Author(s)
      吉田いづみ、前嶋京子、小島至、岸章治
    • Organizer
      第113回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 実験的脈絡膜新生血管とアクチビン2009

    • Author(s)
      吉田いづみ
    • Organizer
      第113回日本眼科学会
    • Place of Presentation
      東京フォーラム
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクチビン及びフォリスタチンによる管腔形成作用2008

    • Author(s)
      前嶋京子、小島至、岸章治
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2008-04-18
    • Related Report
      2010 Final Research Report
  • [Presentation] アクチビン及びフォリスタチンによる管腔形成作用2008

    • Author(s)
      前嶋京子
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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