Investigation and functional analysis of microRNAs in lens and identification of cataract-related genes

• Project/Area Number: 20592036
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Fukui
• Principal Investigator: KUBO Eri University of Fukui, 医学部, 准教授 (10262619)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: micro RNA / 水晶体の発達 / 白内障 / Tropomyosin / Peroxiredoxin6 / microRNA

Research Abstract

We detected the expression and function od microRNAs (miRNAs) which might play important roles as a regulator in lens aging and cataract development. miRNA29a and miR29c may regulate the expression of related genes with posterior capsule opacity after cataract surgery and cataract development of rat lens.

Research Products

• [Presentation] 白内障原因遺伝子を探そう (2011)
  • Author(s): 久保江理
  • Organizer: シンポジウム.第37回水晶体研究会
• [Presentation] Differential expression profiles and Role of MicroRNA in cataractous and non-cat aractous lens epithelial cells from SCR rats, and in response to oxidative stress (2010)
  • Author(s): Kubo E, Hasanova N, Takamura Y, Singh DP, Akagi Y
  • Organizer: ARVO 2010 Annual Meeting
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-03
• [Presentation] 水晶体におけるマイクロRNAの同定と白内障関連遺伝子の解明 (2010)
  • Author(s): 久保江理
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-04-15
• [Presentation] 新しい白内障発症のKeyFactor :トロポミオシン (2010)
  • Author(s): 久保江理.
  • Organizer: シンポジウム.第49回日本白内障学会総会
  • Place of Presentation: 大阪
• [Presentation] Differential expression profiles and role of microRNA in cataractous and non- cataractous lens epithelial cells from SCR rats, and in response to oxidative stress (2010)
  • Author(s): Kubo E, Hasanova N, Takamura Y, Singh DP, Akagi Y
  • Organizer: ARVO 2010 Annual Meeting
  • Place of Presentation: Fort Lauderdale, FL, USA
• [Presentation] 水晶体の酸化ストレスによるmicro RNA発現変化 (2010)
  • Author(s): ハサノワナイリヤ, 久保江理, 高村佳弘, 赤木好男
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 水晶体におけるmicroRNAの同定と白内障関連遺伝子の解明 (2010)
  • Author(s): 久保江理
  • Organizer: シンポジウム.第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] MICRORNA expression profile in the developing, mature and CATARACTOUS rat lens (2009)
  • Author(s): Kubo E
  • Organizer: US-Japan CCRG Meeting 2009
  • Place of Presentation: Kona. Hawaii
  • Year and Date: 2009-12-07
• [Presentation] 白内障発症における microRNAの意義 (2009)
  • Author(s): 久保江理
  • Organizer: 第48回日本白内障学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-06-26
• [Presentation] Microrna Expression Profiling in Developing and Mature Rat Lens (2009)
  • Author(s): Kubo E
  • Organizer: ARVO 2009 Annual Meeting
  • Place of Presentation: Fort Lauderdale, Florida
  • Year and Date: 2009-05-06
• [Presentation] MicroRNA expression profile in the developing, mature and cataractous rat lens (2009)
  • Author(s): Kubo E, Hasanova N, Tanaka Y, Fatma N, Singh DP, Akagi Y
  • Organizer: US-Japan CCRG
  • Place of Presentation: Kona, Hawaii, USA.
• [Presentation] 白内障発症におけるmicr・RNAの意義. (2009)
  • Author(s): 久保江理.
  • Organizer: シンポジウム 第48回日本白内障学会総会
  • Place of Presentation: 東京
• [Presentation] MicroRNA expression profiling in developing and mature rat Lens (2009)
  • Author(s): Kubo E, Hasanova N, Takamura Y, Singh DP, Akagi Y
  • Organizer: ARVO 2009 Annual Meeting
  • Place of Presentation: Fort Lauderdale, FL, USA
• [Presentation] 白内障研究分子生物学的手法 (2009)
  • Author(s): 久保江理
  • Organizer: シンポジウム.第113回日本眼科学会総
  • Place of Presentation: 東京