| Project/Area Number |
20592065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
OGATA NAHOKO Kansai Medical University, 医学部, 准教授 (60204062)
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| Co-Investigator(Renkei-kenkyūsha) |
WADA Mitsumasa 関西医科大学, 医学部, 講師 (40333215)
JYO Nobuo 関西医科大学, 医学部, 助教 (50411533)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糖尿病網膜症 / PEDF / VEGF / 抗VEGF抗 / 小胞体ストレス / tight junction / 血管新生 / 細胞接着分子 |
|---|
| Research Abstract |
We determined the relationship between plasma PEDF levels and renal function in patients with diabetic retinopathy. The levels of plasma PEDF increased with advances in both conditions of diabetic retinopathy and nephropathy. Thus, increased levels of PEDF in the blood may indicate microvascular damages in diabetic patients and may predict the progression of retinopathy and nephropathy. We determine the level of vascular endothelial growth factor (VEGF) in the plasma of patients with proliferative diabetic retinopathy before and after an intravitreal injection of bevacizumab. The decreased levels of blood VEGF after an intravitreal injection of bevacizumab indicate that bevacizumab enters the general circulation and may also affect the PEDF levels. We investigate the effects of endoplasmic reticulum (ER) stress on the tight junctions of the retinal pigment epithelial (RPE) cells in vitro. After the induction of ER, increased expressions of tight junction mole were detected.
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