General and Focal Factors Associated on Progression of Diabetic Retinopathy
Project/Area Number |
20592065
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Kansai Medical University |
Principal Investigator |
OGATA NAHOKO Kansai Medical University, 医学部, 准教授 (60204062)
|
Co-Investigator(Renkei-kenkyūsha) |
WADA Mitsumasa 関西医科大学, 医学部, 講師 (40333215)
JYO Nobuo 関西医科大学, 医学部, 助教 (50411533)
|
Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 糖尿病網膜症 / PEDF / VEGF / 抗VEGF抗 / 小胞体ストレス / tight junction / 血管新生 / 細胞接着分子 |
Research Abstract |
We determined the relationship between plasma PEDF levels and renal function in patients with diabetic retinopathy. The levels of plasma PEDF increased with advances in both conditions of diabetic retinopathy and nephropathy. Thus, increased levels of PEDF in the blood may indicate microvascular damages in diabetic patients and may predict the progression of retinopathy and nephropathy. We determine the level of vascular endothelial growth factor (VEGF) in the plasma of patients with proliferative diabetic retinopathy before and after an intravitreal injection of bevacizumab. The decreased levels of blood VEGF after an intravitreal injection of bevacizumab indicate that bevacizumab enters the general circulation and may also affect the PEDF levels. We investigate the effects of endoplasmic reticulum (ER) stress on the tight junctions of the retinal pigment epithelial (RPE) cells in vitro. After the induction of ER, increased expressions of tight junction mole were detected.
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Report
(4 results)
Research Products
(93 results)
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[Presentation] 糖尿病患者の眼圧2009
Author(s)
松岡雅人、緒方奈保子,他
Organizer
第15回日本糖尿病眼学会
Place of Presentation
名古屋、名古屋国際会議場
Year and Date
2009-12-04
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[Presentation] 感覚器障害の克服を目指して 眼疾患バイオマーカーの探索とモデル動物を用いた予防・治療薬の開発2008
Author(s)
岩田岳, 赤堀正和, 関麻子, 岡本はる, 皆見正好, 尾羽澤実, 木村至, 寺内直樹, 野田徹, 溝田淳, 本田美樹, 田中稔, 林他孝彰, 緒方奈保子, 斉藤善博, 高木郁江, 谷戸正樹
Organizer
第62回国立病院総合医学界会
Place of Presentation
東京
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[Presentation] Plasma Pigment Epithelium-Derived Factor (PEDF) Levels and Diabetic Status in Patients with Diabetic Retinopathy2008
Author(s)
Ogata N, Matsuyama K, Matsuoka, M, Shima C, Tagika A, Nishoyama T, Wada M, Jo N, Matsumura M
Organizer
Annual Meeting of Association for the vision and Ophthalmology
Place of Presentation
USA, Florida
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