A study of molecular mechanisms of endoplasmic reticulum stress in retinal ganglion cell death
| Project/Area Number |
20592082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
SHIMAZAWA Masamitsu Gifu Pharmaceutical University, 薬学部, 准教授 (80381721)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小胞体ストレス / 網膜神経節細胞 / 緑内障 |
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| Research Abstract |
We identified a small molecule, SUN N8075 [(2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-(4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl)-2-p ropanol dimethanesulfonate], which has a marked protective effect on ER stress-induced cell death, in an in vitro cell-based screening. Its protective mechanism was mediated by an induction of VGF nerve growth factor inducible (VGF). Elucidating the involvements of VGF in retinal diseases will be expected to provide a potential target for therapeutic intervention in retinal diseases in future.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Involvement ofendoplasmic reticulum stress onneuronal cell death in the lateralgeniculate nucleus in the monkeyglaucoma model.2011
Author(s)
Ito Y., Shimazawa M., Inokuchi Y.,Yamanaka H., Tsuruma K., Imamura K.,Onoe H., Watanabe Y., Aihara M., AraieM., Hara H.
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Journal Title
European Journal of Neuroscience 33
Pages: 843-855
Related Report
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[Journal Article] An inducer of VGF protectscells from ER stress-induced celldeath and prolongs survival in the mutant SOD1 animal models of familial ALS.2010
Author(s)
Shimazawa M., Tanaka H., Ito Y.,Morimoto N., Tsuruma K., Kadokura M.,Tamura S., Inoue Y., Yamada M.,Takahashi H., Warita H., Aoki M., Hara H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A novel calpaininhibitor,((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945),reduces murine retinal cell death invitro and in vivo.2010
Author(s)
Shimazawa M., Suemori S., Inokuchi Y.,Matsunaga N., Nakajima Y., Oka T.,Yamamoto T., Hara H.
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Journal Title
J. Pharmacol. Exp.Ther 332
Pages: 380-387
Related Report
Peer Reviewed
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