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Corneal Tissue Engineering Using Alginate

Research Project

Project/Area Number 20592083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionDoshisha University

Principal Investigator

KOIZUMI Noriko  Doshisha University, 生命医科学部, 教授 (20373087)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Shigeru  京都府立医科大学, 医学研究科, 教授 (30116024)
Research Collaborator TORII Ryuzou  滋賀医科大学, 動物生命科学研究センター, 教授 (50106647)
OKUMURA Naoki  京都府立医科大学, 眼科, 病院助教 (10581499)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords角膜再生医療 / アルジネート / 細胞移植 / 角膜 / 再生医療 / 組織保存
Research Abstract

We tried to develop a new cryopreservation method for human corneal tissue using alginate encapsulation and we studied the feasibility of cultivated corneal endothelial cell transplantation using a corneal lamellar graft. We cultivated monkey corneal endothelial cells on a frozen preserved human corneal lamellar graft and successfully transplanted this construct into animal eyes. Our results suggest the possibility of cultivated corneal endothelial cell transplantation using a frozen preserved corneal lamellar graft.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (16 results) Book (1 results)

  • [Journal Article] 臨床応用を目指した角膜内皮再生医療の開発2010

    • Author(s)
      小泉範子
    • Journal Title

      同志社大学生命医科学会報 第2号

      Pages: 2-7

    • NAID

      110008792409

    • Related Report
      2010 Final Research Report
  • [Journal Article] 角膜疾患の未来医療2010

    • Author(s)
      木下茂、小泉範子, 他
    • Journal Title

      日本眼科学会雑誌

      Volume: 114 Pages: 161-199

    • NAID

      10026261146

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor2009

    • Author(s)
      Okumura N, Koizumi N, Kinoshita S, et al
    • Journal Title

      Invest Ophthalmol Vis Sci. 50(8)

      Pages: 3680-3687

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cultivated Corneal Endothelial Transplantation in a Primate : Possible Future Clinical Application in Corneal Endothelial Regenerative Medicine.2008

    • Author(s)
      Koizumi N, Kinoshita S, et al.
    • Journal Title

      Cornea. 27(8)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] New strategy for corneal endothelial tissue engineering.2011

    • Author(s)
      小泉範子
    • Organizer
      Asia-ARVO 2011
    • Place of Presentation
      Singapore
    • Year and Date
      2011-01-20
    • Related Report
      2010 Final Research Report
  • [Presentation] New strategy for corneal endothelial tissue engineering2010

    • Author(s)
      Koizumi N
    • Organizer
      2^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      The Westin Miyako, Kyoto, Japan
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] カニクイザルを用いた角膜内皮再生医療の開発2010

    • Author(s)
      小泉範子
    • Organizer
      第14回予防衛生協会セミナー
    • Place of Presentation
      つくば(平成21年度予防衛生協会研究奨励賞受賞講演)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] The existence of dead cells in corneal endothelium preserved with storage media.2010

    • Author(s)
      Tanioka H, Kawasaki S, Adachi H, Inatomi T, Hieda O, Fukuoka H, Okumura N, Koizumi N, Iliakis B, Kinoshita S
    • Organizer
      Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The efficacy of a ROCK inhibitor containing corneal storage medium for corneal endothelial cells.2010

    • Author(s)
      Takahashi H, Koizumi N, Okumura N, Ueno M, Sakamoto Y, Hamuro J, Kinoshita S
    • Organizer
      Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cultivated corneal endothelial transplantation in a primate for the future clinical application of corneal endothelial regenerative medicine2010

    • Author(s)
      小泉範子
    • Organizer
      Gordon Research Conference Biology & Pathobiology of the Cornea
    • Place of Presentation
      Ventura, USA
    • Year and Date
      2010-03-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Cultivated corneal endothelial transplantation in a primate for the future clinical application of corneal endothelial regenerative medicine.2009

    • Author(s)
      Koizumi N
    • Organizer
      the 107th Congress of the German Society of Ophthalmology
    • Place of Presentation
      Congress Center Leipzig(ドイツ)
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 角膜内皮再生医療の現状と展望2009

    • Author(s)
      小泉範子
    • Organizer
      第115回京都眼科学会
    • Place of Presentation
      京都大学芝蘭会館(京都)
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cultivated monkey corneal endothelial cell transplantation using corneal lamellar graft.2009

    • Author(s)
      N.Koizumi, et al.
    • Organizer
      2009 Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2009-05-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Cultivated Monkey Corneal Endothelial Cell Transplantation Using Corneal Lamellar Graft.2009

    • Author(s)
      Koizumi, N., et al.
    • Organizer
      2009 Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Greater Fort Lauderdale/Broward County Convention Center(米国)
    • Year and Date
      2009-05-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 霊長類を用いた培養角膜内皮移植術の開発2009

    • Author(s)
      小泉範子
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京(日本眼科学会学術奨励賞記念講演)
    • Year and Date
      2009-04-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 霊長類を用いた培養角膜内皮移植術の開発2009

    • Author(s)
      小泉範子, 他
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト角膜実質を用いた培養角膜内皮移植術の試み2009

    • Author(s)
      小泉範子, 他
    • Organizer
      第33回角膜カンファランス・第25回角膜移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Cultivated corneal endothelial cell sheet transplantation in a primate mode.2008

    • Author(s)
      小泉範子, et al
    • Organizer
      XVIII International Congress of Eye Research (ICER)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Cryopreservation of corneal tissue combined with alginate encapsulation.2008

    • Author(s)
      Connon CJ, Koizumi N, et al.
    • Organizer
      2008 Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2008-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Cryopreservation of Corneal Tissue Combined With Alginate Encapsulation.2008

    • Author(s)
      Connon CJ (Koizumi N)
    • Organizer
      2008 Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida, U. S. A
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Book] encyclopedia of the eye.(The Ocular Surface : The surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defect, and peripheral corneal ulcer.)2011

    • Author(s)
      Koizumi N, Kinoshita S
    • Publisher
      Elsevier Ltd., Oxfordshire(in press)
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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