| Project/Area Number |
20592085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba University |
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Principal Investigator |
HISHIKI Tomoro Chiba University, 大学院・医学研究院, 講師 (00375776)
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| Co-Investigator(Kenkyū-buntansha) |
TODO Tomoki 東京大学, 医学部附属病院, 特任教授 (80272566)
YOSHIDA Hideo (SHIRASAWA Hiroshi) 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Takeshi 千葉大学, 医学部附属病院, 講師 (20406044)
TERUI Keita 千葉大学, 医学部附属病院, 助教 (70375773)
YAHATA Eriko 千葉大学, 医学部附属病院, 医員 (40456067)
SATO Yoshiharu 千葉大学, 医学部附属病院, 助教 (60375772)
MITSUNAGA Tetsuya 千葉大学, 医学部附属病院, 助教 (80375774)
吉田 英生 千葉大学, 大学院・医学研究院, 教授 (60210712)
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| Co-Investigator(Renkei-kenkyūsha) |
INO Yasushi 東京大学, 医学部附属病院, 特任准教授 ウイルスベクター開発・指導 (50372371)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経芽腫 / 腫瘍融解ウイルス / ヘルペスウイルス / ヒトヘルペスウイルス1型 |
|---|
| Research Abstract |
The antitumor effect of genetically modified human herpes simplex virus-1 (T-01) was assessed in human neuroblastoma models in vitro and in vivo. The results showed that T-01 propagates within and potentially kills neuroblastoma cells with a multiplicity of infection of 0.01. 1x10^6 pfu was capable to show significant growth suppression in nude mice neuroblastoma xenografts. However, T-01 was antagonistic against the cytotoxic effect of cisplatin. Thus, co-use of T-01 and anticancer drugs may not be optimal for the therapeutic strategy for neuroblastomas. T-01 may most be effective when targeted for minimum residual diseases.
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