Clarify the tumor development in multiple neurofibromatosis Type 1 in vitro.
| Project/Area Number |
20592113
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
KIYOKAWA Kensuke Kurume University, 医学部, 教授 (10195399)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Misa 山口大学, 大学院・医学系研究科, 助教 (70379957)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAUCHI Toshihiko 久留米大学, 医学部, 講師 (80239839)
|
|---|
| Research Collaborator |
OHKUMA Aya 山口大学, 大学院・医学系研究科, 大学院生
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 良性腫瘍 / 発生・分化 / 細胞・組織 / 遺伝子 / 病理学 |
|---|
| Research Abstract |
Neurofibromas are benign tumors that comprise primarily of Schwann cells and fibroblasts. Mast cells have been found scattered in the tumor tissue, and their role in promoting the proliferation of neurofibroma has been suggested. We investigated the effectiveness of mast cells in proliferation the tumor growth in vitro. Mast cells significantly promoted proliferation of the NF1 cells and upper the levels of TGF-ss1, SCF and Mn-SOD. On the other hand, tranilast, an anti-allergic drug, is retards tumor proliferation not only suppression of cell growth factor, but also the inhibition of a chemical mediator released from mast cells.
|
Report
(4 results)
Research Products
(19 results)
