Relationship between glycosylation and virulence of surface proteins from periodontopathic bacterium
| Project/Area Number |
20592165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
MURAKAMI Yukitaka Aichi Gakuin University, 歯学部, 教授 (60239506)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Fuminobu 愛知学院大学, 歯学部, 教授 (50001962)
HASEGAWA Yoshiaki 朝日大学, 歯学部, 講師 (70460524)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周病関連細菌 / 表層蛋白質 / 糖鎖修飾 / 病原性 / レクチン / Pgm6/7 / 細胞外マトリックス分子 / 共凝集 / Pgm6 / 7 / RagB |
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| Research Abstract |
Glycosylated proteins from periodontopathic bacterium Porphyromonas gingivalis were examined by carbohydrate-specific staining and lectin blotting. Major outer membrane proteins RagB and Pgm6/7 as well as other three proteins were identified as glycoproteins. Since mutant strains showed reduced colonization and survival rates, these glycoproteins may be involved in virulence of P. gingivalis.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Anchoring and length regulation of Porphyromonas gingivals Mfa1 fimbriae by the downstream gene product Mfa2.2009
Author(s)
Hasegawa Y, Iwami J, Sato K, Park Y, Nishikawa K, Atsumi T, Moriguchi K, Murakami Y, Lamont RJ, Nakamura H, Ohno N, Yoshimura F.
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Journal Title
Microbiology. Vol.155
Pages: 3333-3347
Related Report
Peer Reviewed
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