Evaluation of the neurological substrates for stress induced oral dysesthesia.
Project/Area Number |
20592171
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional basic dentistry
|
Research Institution | Gifu University |
Principal Investigator |
ITOH Kazuo Gifu University, 医学系研究科, 教授 (60093184)
|
Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroyuki 岐阜大学, 医学系研究科, 准教授 (10211434)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | ストレス / 情動 / 口腔感覚 / 三叉神経中脳路核 / 扁桃体 / 青斑核 / 脳 / 神経 / 神経科学 / 解剖学 / 歯学 / 脳・神経 / 線維連絡 / 神経解剖 / 顎運動 / 攻撃行動 |
Research Abstract |
The central nucleus of amygdala and the locus coeruleus are proved to send direct projections to the mesencephalic trigeminal nucleus. Injections of neuronal tract tracers (biotinylated dextran amine, Fast blue) revealed that limited injections of Fast blue into the mesencephalic trigeminal nucleus resulted in retrogradely labeled cells in the central amygdaloid nucleus. Orthograde labeling of the central amygdaloid nucleus resulted in terminal swellings in the mesencephalic trigeminal nucleus. Electron microscopic observation confirmed these findings. Selective cellular labeling of the locus coeruleus using biotinilated dextran amine revealed that the axons of locus coeruleus neurons were followed directly to the mesencephalic trigeminal nucleus gangion cells. The results suggest that emotion and stress directly modify proprioceptive signals from periodontal ligament and masticatory muscles.
|
Report
(4 results)
Research Products
(23 results)
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[Journal Article] Direct projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in rats.2011
Author(s)
Shirasu, M, Takahashi, T., Yamamoto, T., Itoh, K., Sato, S., Nakamura, H.
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Journal Title
Brain Research 1400(in press)
Related Report
Peer Reviewed
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[Journal Article] The locus coeruleus projects to the mesencephalic trigeminal nucleus in rats.2010
Author(s)
Takahashi, T., Shirasu, M., Shirasu, M., Kubo, K., Onozuka, M., Sato, S., Itoh, K., Nakamura, H.
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Journal Title
Neuroscience Research 68
Pages: 103-106
Related Report
Peer Reviewed
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[Book] Novel Trands in Brain Science(Involvement of Dysfunctional Mastication in Cognitive System Deficits in the Mouse.)(Onozuka. M., Yen, C.T.eds.).2008
Author(s)
Watanabe, K., Kubo, K., Nakamura, H., Tachibana, A., Kim, W., Ono, Y., Sasaguri, K., Onozuka, M.
Publisher
Springer
Related Report
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