| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Systemic inflammation causes the age-dependent differential glial responses, but little is known about how age influences the barrier function of leptomeninges during adjuvant arthritis (AA). Microglia expressed IL-1β in the middle-aged AA rats but not in the young AA rats. In the cultured leptomeningeal cells, IL-1β caused a marked loss of occludin. Furthermore, cathepsin B (CB), a typical lysosomal cysteine protease, was found to plays a key role in the pro-IL-1β maturation through the caspase-1 activation in chromogranin A-treated microglia. These findings establish that age strongly influences the barrier functions of the leptomeninges through CB-dependent production of IL-1β by microglia.
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