Roles of cathepsin B in the production of IL-1β as a leptomenigal toxic factor during systemic inflammation
| Project/Area Number |
20592174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKE Hiro Kyushu University, 大学院・歯学研究院, 准教授 (10420598)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Hiroshi 九州大学, 大学院・歯学研究院, 教授 (20155774)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IL-1β / カテプシンB / 末梢炎症 / 髄膜 / グリア細胞 / 髄膜細胞 / アジュバント関節炎 / PGE / ミクログリア / 未着結合蛋白質 / 老化 / PGE_2 / 密着結合蛋白質 / PGE_2〓 |
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| Research Abstract |
Systemic inflammation causes the age-dependent differential glial responses, but little is known about how age influences the barrier function of leptomeninges during adjuvant arthritis (AA). Microglia expressed IL-1β in the middle-aged AA rats but not in the young AA rats. In the cultured leptomeningeal cells, IL-1β caused a marked loss of occludin. Furthermore, cathepsin B (CB), a typical lysosomal cysteine protease, was found to plays a key role in the pro-IL-1β maturation through the caspase-1 activation in chromogranin A-treated microglia. These findings establish that age strongly influences the barrier functions of the leptomeninges through CB-dependent production of IL-1β by microglia.
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Reverse of brain aging by an overexpression of human mitochondrial transcription factor A in mice.2008
Author(s)
Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H.
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Journal Title
J.Neurosci. 28
Pages: 8624-8634
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