| Project/Area Number |
20592317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Foundation for Biomedical Research and Innovation |
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Principal Investigator |
BABA Shunsuke Foundation for Biomedical Research and Innovation, 再生医療研究開発部門, 主任研究員 (40275227)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yoichi 名古屋大学, 医学系研究科, 助教 (20345903)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 足場 / 生体吸収性材料 |
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| Research Abstract |
The purpose of this research is development of functional dental implantable scaffolds under the occulusal pressure by using of PLA which we have already development of biodegradable fabric composite with dynamically high strength, artificial collagen and also bone formation using mesenchymal stem cells(MSCs). First of all, we investigate bone formation as scaffolds made from fabric composite PLA in vitro. Second, we assessed osteogenic ability as the scaffolds using experimental animal model of bone defects in cranium. On the other hands, we evaluated bone formation as the scaffolds made from artificial collagen. And we assessed periodontal regeneration ability as each scaffolds using experimental animal model of bone defects. As the results, it confirmed that using fabric composite PLA as the scaffolds can be bone formation in vitro, can be bone regeneration itselfs even in the aminal models but depend on circumstance, and can be periodontal regeneration ability. It cleared for the MSCs that artificial collagen using as the scaffolds can be not only beneficial functional materials but also bone augmentations itself. Considering the circumstances results, it suggested that PLA and artificial collagen can perform its beneficial materials as the scaffolds, and can be not only scaffolds but also bone replaceable materials itself which have bone regeneration ability.
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