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The relationships between hypermethylation of promotor region of tumor suppressor gene in serum of oral squamous cell carcinoma patients and clinical features

Research Project

Project/Area Number 20592324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionGifu University

Principal Investigator

YAMASHITA Tomomi  Gifu University, 医学系研究科, 准教授 (80345793)

Co-Investigator(Kenkyū-buntansha) KATO Keizo (SHIBATA Toshiyuki / HATAKEYAMA Kaijiro)  岐阜大学, 医学部附属病院, 講師 (40397336)
MAKITA Hiroki  岐阜大学, 医学部附属病院, 講師 (50345790)
畠山 大二郎  岐阜大学, 医学系研究科, 助教 (60377653)
柴田 敏之  岐阜大学, 医学系研究科, 教授 (50226172)
土井田 誠  岐阜大学, 大学院・医学系研究科, 准教授 (90313890)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔癌 / 血清 / 血漿 / メチル化異常
Research Abstract

Hypermethylation of promotor region of tumor suppressor gene in serum of oral squamous cell carcinoma patients before the tumor extirpation was p16 ; 66.7%, MGMT ; 14.3%, RECK ; 4.8%, CDH1 and TIMP-3 ; 0%.
The cases of hypermethylation of promotor region of p16 in serum before the tumor extirpation were investigated about hypermethylation of p16 in serum 3 months after the tumor extirpation. Hypermethylation of p16 was detected in patients with cancer and non-tumor-bearing patients. Hypermethylation of promotor region of p16 did not change before and after the tumor extirpation in serum of oral squamous cell carcinoma patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] The effects of neoadjuvant therapy on the 5-fluorouracil metabolic and relative enzymes of oral squamous cell carcinomas2009

    • Author(s)
      Tomomi Yamashita
    • Journal Title

      Oncology Reports 22

      Pages: 501-507

    • NAID

      120006340795

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas2008

    • Author(s)
      Nguyen Khanh LONG, Keizo KATO, Tomomi YAMASHITA, Hiroki MAKITA, Makoto TOIDA, Daijiro HATAKEYAMA, Akira HARA*, Hideki MORI*, Toshiyuki SHIBATA
    • Journal Title

      Oral Oncology 44

      Pages: 1052-1058

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells.2008

    • Author(s)
      Kato K, Long NK, Makita H, Toida M, Yamashita T, Hatakeyama D, Hara A, Mori H, Shibata T.
    • Journal Title

      British J Cancer. 99(4)

      Pages: 647-654

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas2008

    • Author(s)
      Nguyen Khanh Long
    • Journal Title

      Oral Oncology 44

      Pages: 1052-1058

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of green tea polyphenol on methyaltion status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells2008

    • Author(s)
      Keizo Kato
    • Journal Title

      British Journal of Cancer 99

      Pages: 647-654

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas2010

    • Author(s)
      Nguyen Khanh Long, Keizo Kato, Tomomi Yamashita, Hiroki Makita, Makoto Toida, Daijiro Hatakeyama, Akira Hara, Hideki Mori, Toshiyuki Shibata
    • Organizer
      9th International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      岐阜市、岐阜都ホテル(ワークショップ13)
    • Year and Date
      2010-08-27
    • Related Report
      2010 Final Research Report
  • [Presentation] RECK遺伝子のメチル化と予後との相関および脱メチル化による浸潤制御の可能性2009

    • Author(s)
      加藤恵三、宮崎康雄、馬場政司、畠山大二郎、牧田浩樹、山下知巳、土井田誠、柴田敏之
    • Organizer
      第63回日本口腔科学会総会
    • Place of Presentation
      アクトシティ浜松(2-O-E-6)
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] RECK遺伝子のメチル化と予後との相関および脱メチル化による浸潤制御の可能性2009

    • Author(s)
      加藤恵三
    • Organizer
      日本口腔科学会
    • Place of Presentation
      浜松市・アクトシティ浜松
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔がんにおけるRECK遺伝子のメチル化異常の検索2008

    • Author(s)
      Nguyen Khanh Long
    • Organizer
      日本口腔科学会総会
    • Place of Presentation
      福岡市・福岡国際会議場
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 口腔がんにおけるRECK遺伝子のメチル化異常の検索2008

    • Author(s)
      Nguyen Khanh Long, 加藤恵三, 宮崎康雄, 馬場政司, 畠山大二郎, 牧田浩樹, 山下知巳, 土井田誠, 柴田敏之
    • Organizer
      第62回日本口腔科学会総会
    • Place of Presentation
      福岡市(1-P-F-4)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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