| Project/Area Number |
20592349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
KAWAKAMI Toshiyuki Matsumoto Dental University, 大学院・歯学独立研究科, 教授 (80104892)
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| Co-Investigator(Kenkyū-buntansha) |
KEISUKE Nakano 松本歯科大学, 歯学部, 准教授 (10325095)
NAGATSUKA Hitoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70237535)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔外科学一般 / 歯原性腫瘍 / エナメル上皮腫 / 石灰化嚢胞性歯原性腫瘍 / 石灰化歯原性腫瘍 / 軟骨肉腫 / Notch / Jagged / Delta / ameloblastoma / Notch signaling / 細胞分化 / 細胞増殖 / 免疫組織化学 / 腫瘍の組織型 / 骨吸収 / 顎骨 / 腫瘍 / 歯 / シグナリング |
|---|
| Research Abstract |
We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In summary, the results showed that these morphogenesis regulation Notch and related factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratio was frequently positive, and was nearly the same between the varied histopathological, cytological patterns; however, the less-differentiated cells were slightly fewer in number that that of well-differentiated cells.
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