Angiogenin-induced differentiation of endothelial progenitor cell and the mechanism of tumor angiogenesis

• Project/Area Number: 20592359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: KISHIMOTO Koji Okayama University, 大学院・医歯薬学総合研究科, 助教 (40243480)
• Co-Investigator(Kenkyū-buntansha): SASAKI Akira 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00170663)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: angiogenin / 血管内皮前駆細胞 / 血管新生 / 分化誘導 / 癌 / Angiogenin

Research Abstract

Angiogenic factor, angiogenin underwent nuclear translocation in endothelial progenitor cell (EPC) in a cell density-independent manner and induced ribosome biogenesis, and cell proliferation. Angiogenin also increased EPC migration and invasion into the oral squamous cell carcinoma cell clusters. Moreover, various angiogenic factors such as bFGF and VEGF stimulated nuclear accumulation of endogenous angiogenin in EPC. These results suggest that angiogenin plays an important role in the tumor angiogenesis by EPC.

Research Products

• [Presentation] Angiogeninの発現亢進は口腔癌の増殖と進展に関与する (2011)
  • Author(s): 岸本晃治
  • Organizer: 第29回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 熊本
  • Year and Date: 2011-01-27
• [Presentation] UP-REGULATION OF ANGIOGENIN IS INVOLVED IN ORAL TUMORIGENESIS AND CANCER PROGRESSION (2010)
  • Author(s): 岸本晃治
  • Organizer: 9th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Kuala Lumpur
  • Year and Date: 2010-11-27
• [Presentation] Down-regulation angiogenin suppresses cancer-induced osteolysis in oralsquamous cell carcinoma (2009)
  • Author(s): 吉岡徳枝
  • Organizer: 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: 上海
• [Presentation] Angiogeninの発現抑制は口腔扁平上皮癌における癌誘発の肯破壊を抑制する (2009)
  • Author(s): 吉岡徳枝
  • Organizer: 第68回 日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Expression and role of angiogenin under hypoxia in oral cancer (2008)
  • Author(s): 岸本晃治
  • Organizer: 8th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Bangkok
  • Year and Date: 2008-11-06
• [Presentation] Expression and role of angiogenin under hypoxia in oral cancer (2008)
  • Author(s): 岸本 晃治
  • Organizer: The 8th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: バンコク
  • Year and Date: 2008-11-06
• [Presentation] 口腔癌においてangiogeninは低酸素環境下で高発現し腫瘍血管新生および細胞増殖に関与する (2008)
  • Author(s): 岸本晃治
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Remarks] ホームページ等
  • URL: http://www.dent.okayama-u.ac.jp/2kouge/index_sc_j.html