Search for the bioactive compounds from the marine invertebrates and the basic study of application of them to novel anticancer drugs

• Project/Area Number: 20592361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: YOSIOKA Yukio Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (20335665)
• Co-Investigator(Kenkyū-buntansha): OKAMOTO Tetsuji 広島大学, 医歯薬学総合研究科, 教授 (00169153) ; OJIKA Makoto 名古屋大学, 農学生命科学研究科, 教授 (50152492) ; TORATANI Shigeaki 広島大学, 病院, 講師 (90172220) ; SHINTANI Tomoaki 広島大学, 病院, 助教 (90403518)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 海洋生物 / 生理活性物質 / 抗腫瘍効果 / 血管新生 / 新規抗癌剤 / 転移・浸潤

Research Abstract

We extract and refine the bioactive compounds from the marine invertebrates to a index of cytotoxicity against squamous cell carcinoma cells. We pick up some high activity ones from many bioactive compounds and identify them and try to compose some novel derivatives as massive as we can. We analyze their constitution and function of high activity ones, and inspect of their utility by animal experiments.

Research Products

• [Journal Article] 偽悪性変化を伴った下顎歯肉腫瘤の1例 (2010)
  • Author(s): 吉岡幸男, 小川郁子, 林堂安貴, 虎谷茂昭, 高田隆, 岡本哲治
  • Journal Title: 日本口腔科学会雑誌 59(2) Pages: 63-67
  • NAID: 10027093100
  • Peer Reviewed
• [Journal Article] 偽悪性変化を伴った下顎歯肉腫瘤の1例 (2010)
  • Author(s): 吉岡幸男
  • Journal Title: 日本口腔科学会雑誌 59 Pages: 63-67
  • NAID: 10027093100
  • Peer Reviewed
• [Presentation] 下顎粉砕骨折を伴った広範囲な口腔顎顔面外傷の治療の一例 (2010)
  • Author(s): 吉岡幸男, 虎谷茂昭, 林堂安貴, 竹末奈七子, 伊藤翼, 久保隆靖, 高本宗男, 広橋伸之, 谷川攻一, 岡本哲治
  • Organizer: 第12回日本口腔顎顔面外傷学会総会学術大会
  • Place of Presentation: 於広島県民文化センター
  • Year and Date: 2010-07-17
• [Presentation] 下顎歯肉に発生したinflammatory gingival hyperplasia with pseudomalignant changeの一例 (2008)
  • Author(s): 吉岡幸男, 小川郁子, 北川雅恵, 谷亮治, 林堂安貴, 虎谷茂昭, 高田隆, 岡本哲治
  • Organizer: 第56回NPO法人日本口腔科学会 中国・四国地方部会
  • Place of Presentation: 於 鳥取大学医学部記念講堂
  • Year and Date: 2008-11-29