Search for the bioactive compounds from the marine invertebrates and the basic study of application of them to novel anticancer drugs
| Project/Area Number |
20592361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YOSIOKA Yukio Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (20335665)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬学総合研究科, 教授 (00169153)
OJIKA Makoto 名古屋大学, 農学生命科学研究科, 教授 (50152492)
TORATANI Shigeaki 広島大学, 病院, 講師 (90172220)
SHINTANI Tomoaki 広島大学, 病院, 助教 (90403518)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 海洋生物 / 生理活性物質 / 抗腫瘍効果 / 血管新生 / 新規抗癌剤 / 転移・浸潤 |
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| Research Abstract |
We extract and refine the bioactive compounds from the marine invertebrates to a index of cytotoxicity against squamous cell carcinoma cells. We pick up some high activity ones from many bioactive compounds and identify them and try to compose some novel derivatives as massive as we can. We analyze their constitution and function of high activity ones, and inspect of their utility by animal experiments.
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Report
(4 results)
Research Products
(4 results)
