Pain sensations of oral region in rat models of Parkinson's disease

• Project/Area Number: 20592371
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: NIWA Hitoshi Osaka University, 大学院・歯学研究科, 教授 (30218250)
• Co-Investigator(Kenkyū-buntansha): SUGIMURA Mitsutaka 大阪大学, 大学院・歯学研究科, 准教授 (90244954)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: パーキンソン病 / 痛覚 / 三叉神経 / 疼痛関連行動 / c-Fos / ホルマリンテスト / 痔痛関連行動 / 疼痛感覚 / ホルマチンテスト / 体性感覚誘発電位 / ラット

Research Abstract

Parkinson's disease model rats (PD rat) were injected formalin into the left upper lip. The numbers of pain-related-behavior (PRB) and c-Fos or ERK positive cells in the trigeminal nucleus caudalis were counted after formalin injection. PD rats with contralateral injection showed a decrease in PRB during the first 5 min, however, there was no significant change in ERK expression compared with sham rats. The number of PRBs and c-Fos expression increase in PD rats with ipsilateral injection. These results suggest that the PD rat is in hyperalgesia, however, the behavioral response to pain is blunted.

Research Products

• [Presentation] Behavioral responses and Fos expression following facial painful stimuli in hemi-parkinsonian rats (2010)
  • Author(s): Maegawa H, Sugiyo A, Masawaki A, Oyamaguti A, Yoshida A, Kato T, Niwa H
  • Organizer: Neuroscience 2010
  • Place of Presentation: サンディエゴ・インターナショナル・コンベンションセンター(USA)
  • Year and Date: 2010-11-16
• [Presentation] Behavioral responses and Fos expression following facial painful stimuli in hemi-parkinsonian rats (2010)
  • Author(s): Maegawa H, Masawaki A, Morimoto Y, Kato T, Yoshida A, Niwa H
  • Organizer: The 13^<th> Asian Australasian Congress of Anesthesioligists
  • Place of Presentation: 福岡市・マリンメッセ
  • Year and Date: 2010-06-03
• [Presentation] Behavioral responses and Fos expression following facial painful stimuli in hemi-parkinsonian rats (2010)
  • Author(s): Maegawa H., et al
  • Organizer: The 13^<th> Asian Auatralasian Congress of Aneathesioligists
  • Place of Presentation: 福岡市・マリンメッセ
  • Year and Date: 2010-06-03