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Development of neural circuit for generation of sucking movement

Research Project

Project/Area Number 20592372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

ISHIHAMA Kohji  Matsumoto Dental University, 歯学部・附属病院, 講師 (30432454)

Co-Investigator(Kenkyū-buntansha) YASUDA Kouichi  松本歯科大学, 大学院・歯学独立研究科, 准教授 (30230220)
TANAKA Susumu  大阪大学, 大学院・歯学研究科, 招聘教員 (00367541)
SHIMOJI Shigehiro  松本歯科大学, 歯学部, 助手 (10549380)
OKAYAMA Masaki  松本歯科大学, 歯学部, 助手 (90549370)
YAMADA Takahisa  松本歯科大学, 歯学部, 助手 (30549382)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords哺乳 / 神経回路網 / 発達 / NMDA / シナプス
Research Abstract

Rat fetal jaw movements were observed at from embryonic 17 days. The neural circuit for the generation of rhythmical jaw movement participated in NMDA and non-NMDA receptors. The amount of diet intake was 1.0g, 0.9g, and 2.3g in rats injected NMDA antagonist, non-NMDA antagonist, and saline, respectively. The emergence of the synapse related protein in the trigeminal motor nucleus was observed at E16. We considered the neural circuit for the feeding behavior initially formed around this embryonic stage.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2011 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (23 results)

  • [Journal Article] Long-term potentiation of intrinsic excitability in trigeminal motoneurons.2010

    • Author(s)
      Okamoto R, Enomoto A, Koizumi H, Tanaka S, Ishihama K, Kogo M.
    • Journal Title

      Brain Res 1312

      Pages: 32-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha2-adrenoceptors coordinate swallowing and respiration.2010

    • Author(s)
      Yamanishi T, Takao K, Koizumi H, Ishihama K, Nohara K, Komaki M, Enomoto A, Yokota Y, Kogo M.
    • Journal Title

      J Dent Res 89

      Pages: 258-63

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of the postnatal development of muscle-spindle and periodontal-ligament neurons in the mesencephalic trigeminal nucleus of the rat.2010

    • Author(s)
      Umemura T, Yasuda K, Ishihama K, Yamada H, Okayama M, Hasumi-Nakayama Y, Furusawa K.
    • Journal Title

      Neurosci Lett 473

      Pages: 155-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone formation without lamina dura in the middle-aged and elderly : possible dependence on enamel.2010

    • Author(s)
      Yamaoka M, Ishizuka M, Ishihama K, Takahashi M, Takahashi M, Yamada H, Teramoto Y, Yasuda K, Shiba T, Uematsu T, Furusawa K.
    • Journal Title

      Clin Interv Aging 5

      Pages: 37-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Floating aerial blood mists in the operating room.2010

    • Author(s)
      Ishihama K, Sumioka S, Sakurada K, Kogo M.
    • Journal Title

      J Hazard Mater 181

      Pages: 1179-81

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occupational safety among dental health care workers2010

    • Author(s)
      Shimoji S, Ishihama K, Yamada H, Okayama M, Yasuda K, Shibutani T, Ogasawara T, Miyazawa H, Furusawa K.
    • Journal Title

      Advances in Medical Education and Practice 1

      Pages: 41-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood contamination of environmental surfaces in outpatient oral surgery operatory.2010

    • Author(s)
      Wada T, Ishihama K, Yonemitsu K, Sumioka S, Yamada C, Higuchi M, Kogo M.
    • Journal Title

      Asian J Oral Maxillofac Surg 22

      Pages: 12-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precontoured mandibular plate with three-dimensional model significantly shortened the mandibular reconstruction time.2010

    • Author(s)
      Yamada H, Ishihama K, Yasuda K, Hasumi-Nakayama Y, Okayama M, Yamada T, Furusawa K.
    • Journal Title

      Asian J Oral Maxillofac Surg 22

      Pages: 198-201

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inferior alveolar nerve canal and branches detected with cone beam dental CT in lower third molar region.2010

    • Author(s)
      Yamada T, Ishihama K, Yasuda K,Hasumi-Nakayama Y, Ito K, Yamaoka M, Furusawa K.
    • Journal Title

      J Oral Maxillofac Surg in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related disruption of the lamina dura: evidence in the mandibular horizontal incompletely impacted third molar.2009

    • Author(s)
      Yamaoka M, Takahashi M, Ishihama K, Uematsu T, Furusawa K.
    • Journal Title

      Clin Interv Aging 4

      Pages: 451-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mandibular fractures in severely developmental disabled persons.2009

    • Author(s)
      Idoji Y, Ishihama K, Iida S, Yamanishi H, Kogo M.
    • Journal Title

      J Trauma 66

      Pages: 704-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence of floating aerosolized blood mist during oral surgery.2009

    • Author(s)
      Ishihama K, Koizumi H, Wada T, Iida S, Tanaka S, Yamanishi T, Enomoto A, Kogo M.
    • Journal Title

      J Hosp Infect 71

      Pages: 359-64

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of trigeminal respiratory motor activity in the brainstem.2009

    • Author(s)
      Koizumi H, Nomura K, Yokota Y, Enomoto A, Yamanishi T, Iida S, Ishihama K, Kogo M.
    • Journal Title

      J Dent Res 88

      Pages: 1048-53

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of neurons in locus coeruleus in inhibitory effect on glossopharyngeal expiratory activity in a neonatal rat brainstem-spinal cord preparation in vitro.2008

    • Author(s)
      Yamanishi T, Koizumi H, Komaki M, Ishihama K, Adachi T, Enomoto A, Takao K, Iida S, Kogo M.
    • Journal Title

      Neurosci Res 60

      Pages: 2-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High incidence of blood exposure due to imperceptible contaminated splatters during oral surgery.2008

    • Author(s)
      Ishihama K, Iida S, Koizumi H, Wada T, Adachi T, Isomura-Tanaka E, Yamanishi T, Enomoto A, Kogo M.
    • Journal Title

      J Oral Maxillofac Surg 66

      Pages: 704-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patient safety in a dental university hospital. Review of adverse events and incident reports.2008

    • Author(s)
      Ishihama K, Yasuda K, Nakayama Y, Ono Y, Umemura T, Miyashita M, Yamada H, Shibutani T, Furusawa K.
    • Journal Title

      Hosp Dent 20

      Pages: 95-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiomyolipoma of the tongue.2008

    • Author(s)
      Koizumi H, Ishihama K, Enomoto A, Kogo M.
    • Journal Title

      Br J Oral Maxillofac Surg 46

      Pages: 3-4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 下唇粘液貯留嚢胞摘出術後の下唇知覚異常と組織学的検討2011

    • Author(s)
      木田久美子、石濱孝二、山西整、磯村恵美子、大槻浩一、古郷幹彦
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      新潟大学
    • Year and Date
      2011-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎智歯抜去時における臼歯枝損傷の可能性2011

    • Author(s)
      山田高久、石濱孝二、安田浩一、中山洋子、梅村哲弘、山田秀史、宮下みどり、伊藤香那、古澤清文
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      新潟大学
    • Year and Date
      2011-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット三叉神経運動核におけるシナプス関連タンパクの発現について2010

    • Author(s)
      岡山政樹、石濱孝二、安田浩一、中山洋子、梅村哲弘、山田秀史、下地茂弘、山田高久、伊藤香那、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 不確縫線核ニューロンによる呼吸恒常性の維持機構2010

    • Author(s)
      山西整、原田丈司、石濱孝二、森本泰成、宮成典、辻忠孝、大槻浩一、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎埋伏智歯抜去術における血液飛沫曝露について2010

    • Author(s)
      下地茂弘、石濱孝二、安田浩一、山田秀史、中山洋子、梅村哲弘、宮下みどり、岡山政樹、山田高久、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎生期におけるNMDA, non-NMDA受容体拮抗薬投与と生後ラットの顎口腔機能の行動学的影響について2010

    • Author(s)
      岡山政樹、石濱孝二、安田浩一、中山洋子、梅村哲弘、山田秀史、下地茂弘、山田高久、伊藤香那、古澤清文
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎生期におけるNMDA,non-NMDA受容体拮抗薬投与と生後ラットの顎口腔機能の行動学的影響について2010

    • Author(s)
      岡山政樹
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下顎智歯抜歯における下歯槽神経臼歯枝損傷の可能性について2010

    • Author(s)
      山田高久、石濱孝二、安田浩一、中山洋子、梅村哲弘、山田秀史、宮下みどり、伊藤香那、山岡稔、古澤清文
    • Organizer
      日本口腔科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 上顎骨に対する外科手術後の感覚異常について2010

    • Author(s)
      伊藤香那、中山洋子、小笠原慶一、梅村哲弘、安田浩一、古澤清文
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      大阪歯科大学
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 頸部郭清術術後における副神経に関わる上腕運動の機能評価2010

    • Author(s)
      山田謙一、山西整、辻忠孝、沢井奈津子、田中晋、住岡聡、大槻浩一、磯村恵美子、古郷幹彦、大倉正也
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      大阪歯科大学
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 舌感覚が嚥下時の舌口蓋接触圧パターンに及ぼす影響2010

    • Author(s)
      小橋寛薫、山西整、田中晋、谷口佳孝、田峰謙一、野原幹司、石濱孝二、小野雄大、小野高裕、古郷幹彦
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      大阪歯科大学
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 当科において三叉神経痛と診断された症例の統計学的検討2010

    • Author(s)
      山本奈穂、山西整、李篤史、田中晋、宮成典、應谷昌隆、奥野恵実、石濱孝二、古郷幹彦
    • Organizer
      口腔顔面神経機能学会
    • Place of Presentation
      大阪歯科大学
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット三叉神経運動核におけるシナプス関連タンパクの発生学的変化2009

    • Author(s)
      岡山政樹、石濱孝二、山田秀史、安田浩一、中山洋子、梅村哲弘、山田高久、小笠原慶一、山岡稔、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] NMDA誘発性顎運動時の三叉神経中脳路核ニューロンの神経活動2009

    • Author(s)
      榎本明史、小泉英彦、田中晋、岡本怜子、辻忠孝、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 三叉神経運動ニューロンにおける神経可塑性についての研究2009

    • Author(s)
      岡本怜子、榎本明史、小泉英彦、田中晋、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳内オレキシン活性レベルが摂食行動パタンへ与える影響2009

    • Author(s)
      辻忠孝、田中晋、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎埋伏智歯抜歯における歯科用CT を用いた術前評価の有用性2009

    • Author(s)
      山田高久、石濱孝二、安田浩一、中山洋子、梅村哲弘、山田秀史、宮下みどり、伊藤香那、山岡稔、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 下顎埋伏智歯抜歯におけるエアロゾルの発生要因について2009

    • Author(s)
      下地茂弘、石濱孝二、安田浩一、山田秀史、中山洋子、梅村哲弘、宮下みどり、岡山政樹、山岡稔、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット三叉神経におけるシナプス関連タンパクの胎生期変化について2009

    • Author(s)
      山田秀史、石濱孝二、安田浩一、中山洋子、梅村哲弘、下地茂弘、岡山政樹、山田高久、山岡稔、古澤清文
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯科治療時に発生するエアロゾルについて2009

    • Author(s)
      山田秀史、石濱孝二、安田浩一、中山洋子、梅村哲弘、宮下みどり、山岡稔、古澤清文
    • Organizer
      日本口腔科学会総会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 三叉神経中脳路核ニューロンの生後発達とセロトニンによる神経修飾2008

    • Author(s)
      梅村哲弘、安田浩一、中山洋子、石濱孝二、古澤清文
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      徳島 アクティとくしま
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 中央手術室の排気ダクトで捕集された血液について2008

    • Author(s)
      住岡聡、石濱孝二、田中晋、和田剛信、樋口将隆、並川麻理、山田智明、飯田征二、小泉英彦、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      徳島 アクティとくしま
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔悪性腫瘍手術施行症例における術後感染について2008

    • Author(s)
      樋口将隆、石濱孝二、田中晋、住岡聡、和田剛信、吉村奈津子、相川友直、大倉正也、古郷幹彦
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      徳島 アクティとくしま
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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