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Elucidation of the mechanism to trigger brux like movement in gastric-esophageal acid reflux model

Research Project

Project/Area Number 20592406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKagoshima University

Principal Investigator

KAMIMURA Hiroki  Kagoshima University, 医歯学総合研究科・歯科矯正学分野, 助教 (50464467)

Co-Investigator(Kenkyū-buntansha) MIYAWAKI SHouichi  鹿児島大学, 医歯(薬)学総合研究科・歯科矯正学分野, 教授 (80295807)
INUI Akio  鹿児島大学, 医歯(薬)学総合研究科・心身内科学分野, 教授 (80168418)
NAGATA Junko  宮崎大学, 医学部付属病院・顎顔面口腔外科学分野, 講師 (50264429)
FUKUNAGA Tomohiro  東北大学, 大学院・歯学研究科・顎口腔矯正学分野, 講師 (70362994)
OMURE Haruhito  鹿児島大学, 医歯(薬)学総合研究科・歯科矯正学分野, 講師 (00404484)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsブラキシズム / 歯科矯正 / 歯科矯正学 / 胃食道逆流 / ラット / 胃食道逆流症 / 筋電図
Research Abstract

The expression mechanism of bruxism is not to be revealed. Although it is suggested that the relationship between Gastroesophageal acid reflux disease and bruxism, it is important to investigate the expression mechanism in an animal experiment for reveal. However, there is no animal model to clarify the relationship. Therefore, in the present study we created the gastric-esophageal acid reflux animal model for capable to observation of masseter muscle activity for explore the relationship between Gastroesophageal acid reflux and bruxism. We clarified that brux like movement was induced by stimulation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 19 results) Presentation (36 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Influence of Experimental Esophageal Acidification on Sleep Bruxism:A randomized trial.2011

    • Author(s)
      Ohmure H, Oikawa K, K.kanematsu, Y.Saito, T.Yamamoto, H.Nagahama, H.Tsubouchi, Miyawaki S.
    • Journal Title

      Journal of Dental Research 90

      Pages: 665-671

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Experimental Esophageal Acidification on Sleep Bruxism : Arandomized trial2011

    • Author(s)
      Ohmure H, Oikawa K, K.kanematsu, Y.Saito, T.Yamamoto, H.Nagahama, H.Tsubouchi, Miyawaki S
    • Journal Title

      Journal of Dental Research

      Volume: 90 Pages: 665-671

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎切歯根尖部に水平埋伏した犬歯の開窓・牽引を行った一治験例2011

    • Author(s)
      上村裕希, 北嶋文哲, 迫口陽子, 飯野祥一朗, 宮脇正一
    • Journal Title

      九州矯正歯科学会雑誌

      Volume: 6 Pages: 71-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences between sliding mechanics with implant anchorage and straight-pull headgear and intermaxillary elastics in adults with bimaxillary protrusion2010

    • Author(s)
      Koyama I, Iino S, Abe Y, Takano-Yamamoto T, Miyawaki S
    • Journal Title

      European Journal of Orthodontics

      Volume: 33 Pages: 126-131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Magnetization Transfer Contrast Imaging for Edematous Changes in Masticatory Muscle2010

    • Author(s)
      Nagayama K, Suenaga S, Nagata J, Takada H, Majima H, Miyawaki S
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 34 Pages: 233-241

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 私共の地域貢献への取り組み2010

    • Author(s)
      宮脇正一
    • Journal Title

      鹿児島大学紀要

      Volume: 30 Pages: 7-8

    • NAID

      120005231970

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Magnetization Transfer Contrast Imaging for Edematous Changes in Masticatory Muscle2010

    • Author(s)
      Nagayama K, Suenaga S, Nagata J, Takada H, Majima H, Miyawaki S
    • Journal Title

      Journal of Computer Assisted Tomography 34

      Pages: 233-241

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain intensity during the first 7 days following the appliciation of light and heavy continuous foeces.2009

    • Author(s)
      Ogura M, Kamimura H, Al-Kalaly A, Nagayama K, Taira K, Nagata J, Miyawaki S.
    • Journal Title

      European Journal of Orthodontics 31

      Pages: 314-319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastroesophageal reflux symptoms in adults with skeletal Class III malocclusion examined by questionnaires.2009

    • Author(s)
      Togawa R, Ohmure H, Sakaguchi K, Takada H, Oikawa K, Nagata J, Yamamoto T, Tsubouchi H, Miyawaki S.
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics 133

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal craniofacial changes in Japanese adults with untreated maxillary and mandibular protrusions2009

    • Author(s)
      Kuroda S, Okada T, Ishimitsu T, Tanimotio Y, Miyawaki S, Takano-Yamamoto T
    • Journal Title

      Orthodontic Waves 68

      Pages: 158-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain intensity during the first 7 days following the appliciation of light and heavy continuous foeces2009

    • Author(s)
      Ogura M, Kamimura H, Al-Kalaly A, Nagayama K, Taira K, Nagata J, Miyawaki S
    • Journal Title

      European Journal of Orthodontics 31

      Pages: 314-319

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice2009

    • Author(s)
      Okamoto A, Ohnishi T, Bandow K, Kakimoto K, Chiba N, Maeda A, Fukunaga T, Miyawaki S, Matsuguchi T
    • Journal Title

      European Journal of Oral Sciences 117

      Pages: 238-247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Mandibular Advancement plus Prohibition of Lower Incisor Movement on Mandibular Growth in Rats2009

    • Author(s)
      Taira K, Iino S, Kubota T, Fukunaga T, Miyawaki S
    • Journal Title

      The Angle Orthodontist 79

      Pages: 1095-1101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastroesophageal reflux symptoms in adults with skeletal Class III malocclusion examined by questionnaires2009

    • Author(s)
      Togawa R, Ohmure H, Sakaguchi K, Takada H, Oikawa K, Nagata J, Yamamoto T, Tsubouchi H, Miyawaki S
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics 133

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃食道酸逆流とブラキシズムとの新たな関係2008

    • Author(s)
      宮脇正一
    • Journal Title

      Dental Diamond 33(5)

      Pages: 74-77

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] Growth hormone releasing peptide 2 reverse anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice.2008

    • Author(s)
      Perboni S
    • Journal Title

      World J Gastroenterol 14

      Pages: 6303-6305

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different effects of ghrelin, des-acyl ghrelin andobestatin on gastroduodenal motility in conscious rats.2008

    • Author(s)
      Fujimiya M
    • Journal Title

      World J Gastroenterol 14

      Pages: 6318-6326

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences between sliding mechanics with implant anchorage and straight-pull headgear and intermaxillary elastics in adults with bimaxillary protrusion

    • Author(s)
      Koyama I, Iino S, Abe Y, Takano-Yamamoto T, Miyawaki S.
    • Journal Title

      European Journal of Orthodontics (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain intensity during the first 7 days following the application of light and heavy continuous forces.

    • Author(s)
      Ogura M
    • Journal Title

      Eur J Orthod (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastro-esophageal reflux symptoms in adult patientswith skeletal Class III malocclusion as examined by questionaire

    • Author(s)
      Togawa R
    • Journal Title

      Am J Orthod Dentfacial Orthop (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 下顎歯列後方部の萌出スペースと顎顔面形態との関連性について2011

    • Author(s)
      上村裕希、友成博、北嶋文哲、宮脇正一
    • Organizer
      第6回九州矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Annual Research Report
  • [Presentation] リップバンパーを用いた上顎大臼歯の遠心移動後、チタンスクリューを併用したAngle II級1類症例2011

    • Author(s)
      友成博、八木孝和、上村裕希、宮脇正一
    • Organizer
      第6回九州矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Annual Research Report
  • [Presentation] A new physiological signifi cance of sleep bruxism.2010

    • Author(s)
      宮脇正一
    • Organizer
      TOS annual meeting
    • Place of Presentation
      台湾,台北市
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] A new physiological significance of sleep bruxism2010

    • Author(s)
      宮脇正一
    • Organizer
      TOS annual meeting
    • Place of Presentation
      台北
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠時ブラキシズムに対する考え方と対処法2010

    • Author(s)
      宮脇正一
    • Organizer
      一般社団法人日本顎関節学会第27回学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 食道内の酸・ペプシンがラットのブラキシズム様運動に及ぼす影響2010

    • Author(s)
      北嶋文哲, 上村裕希, 窪田健司, 大牟禮治人, 宮脇正一
    • Organizer
      第69回日本矯正歯科学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] お口と身体の意外な関係について2010

    • Author(s)
      宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会(市民公開講座)
    • Place of Presentation
      鹿児島市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 食道刺激モデルの開発2010

    • Author(s)
      北嶋文哲、上村裕希、窪田健司、永田順子、宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 咀嚼運動が胃排出能に及ぼす影響(第一報)2010

    • Author(s)
      高田寛子、大牟禮治人、上原沢子、楠元順哉、水枝谷彬代、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 一般集団における咬合と顎口腔機能の異常は胃食道逆流症のリスク要因となるか2010

    • Author(s)
      國則貴玄、永田順子、坂口勝義、楠元順哉、宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠時の咀嚼筋活動と食道内の酸クリアランスとの関係2010

    • Author(s)
      及川紀佳子、大牟禮治人、高田寛子、齋藤陽子、兼松恭子、山元隆文、坪内博仁、宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 垂直性骨欠損に伴う不正咬合患者に歯周組織再生療法と矯正治療を併用した一症例2010

    • Author(s)
      國則貴玄, 山本芳丈, 白方良典, 宮脇正一
    • Organizer
      第69回日本矯正歯科学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯科医師と模擬患者の相互理解に関する研究-矯正患者への医療面接-2010

    • Author(s)
      吉田礼子, 窪田健司, 宮脇正一
    • Organizer
      第69回日本矯正歯科学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小・中学生の問題行動と睡眠、胃食道逆流症状に関する因子の検討2010

    • Author(s)
      坂口勝義, 斎藤陽子, 兼松恭子, 永山邦宏, 植田紘貴, 大牟禮治人, 宮脇正一
    • Organizer
      第69回日本矯正歯科学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] MyD88シグナル経路は骨牙細胞において機械的刺激によるケモカインの発現を誘導する2010

    • Author(s)
      前田綾, 坂東健二郎, 上原沢子, 宮脇正一, 松口徹也
    • Organizer
      第69回日本矯正歯科学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃食道逆流を感知する咽喉頭・食道の化学受容器の分布パターン2010

    • Author(s)
      窪田健司, 中山歩, 吉田礼子, 原田秀逸, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 矯正治療中の患者を想定した医療面接における歯科医師と模擬患者の相互理解に関する研究2010

    • Author(s)
      吉田礼子, 窪田建司, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一般集団における咬合と顎口腔機能の異常は胃食道逆流症のリスク要因となるか?2010

    • Author(s)
      國則貴玄, 永田順子, 坂口勝義, 楠元順哉, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中学生における問題行動と生活・睡眠、胃食道逆流との関係に関する調査2010

    • Author(s)
      水溜美香, 坂口勝義, 永田順子, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] エッジワイズ装置撤去後にマウスピース型矯正装置を用いて空隙閉鎖を行った2症例2010

    • Author(s)
      飯野祥一朗, 上村裕希, 平良幸治, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下顎切歯根尖部に水平埋伏した犬歯の開窓・牽引を行った一例2010

    • Author(s)
      上村裕希, 飯野祥一朗, 窪田健司, 北嶋文哲, 宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠時の食道内への繰り返しの酸刺激が咀嚼筋活動に及ぼす影響2009

    • Author(s)
      及川紀佳子, 大牟禮治人, 高田寛子, 斎藤陽子, 兼松恭子, 長濱博行, 坪内博仁, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] 口、食道、胃の密接な関係-矯正歯科医の果たす役割-2009

    • Author(s)
      宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠時の食道内への酸の注入がブラキシズムの発現に及ぼす影響2009

    • Author(s)
      大牟禮治人, 及川紀佳子, 兼松恭子, 北嶋文哲, 楠本順哉, 山元隆文, 坪内博仁, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] 一般集団における咬み合わせ、咀嚼機能、胃腸消化器症状ならびに睡眠障害に関する質問紙調査(第一報)2009

    • Author(s)
      國則貴玄, 坂口勝義, 永田順子, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] 口、食道、胃の密接な関係―矯正歯科医の果たす役割―2009

    • Author(s)
      宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠時の食道内への繰り返しの酸刺激が咀嚼筋活動に及ぼす影響2009

    • Author(s)
      及川紀佳子, 大牟禮治人, 高田寛子, 斎藤陽子, 兼松恭子, 長濱博行, 坪内博仁, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠時脳波の指数スペクトルの傾きと睡眠段階との関連性2009

    • Author(s)
      永田順子, 上村裕希, 齋藤陽子, 北嶋文哲, 長濱博行, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠時の食道内への酸の注入がブラキシズムの発現に及ぼす影響2009

    • Author(s)
      大牟禮治人, 及川紀佳子, 兼松恭子, 北嶋文哲, 楠本順哉, 山元隆文, 坪内博仁, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 宮脇正一多数歯欠如を伴う骨格性下顎前突の1症例2009

    • Author(s)
      岡本敦子, 飯野祥一朗, 福永智広, 杉原一正
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一般集団における咬み合わせ、咀嚼機能、胃腸消化器症状ならびに睡眠障害に関する質問紙調査(第一報)2009

    • Author(s)
      國則貴玄, 坂口勝義, 永田順子, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] チタンスクリューを用いて下顎臼歯の垂直的コントロールと近心移動を行った骨格性II級ハイアングル症例2009

    • Author(s)
      前田綾, 友成博, 高田寛子, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小学生の睡眠障害、心理社会的問題および胃食道逆流症状に関する質問紙調査(第一報)2009

    • Author(s)
      水溜美香, 坂口勝義, 永田順子, 宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] A case of Limb-Girdle type muscular dystrophy2009

    • Author(s)
      Yoshitake YAMAMOTO, Kiyoko OIKAWA, Hiroko TAKADA, Shouichi MIYAWAKI
    • Organizer
      第68回日本矯正歯科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Magnetization Transfer Contrast 法による咀嚼筋内炎症性病変の描出能に関する検討2009

    • Author(s)
      永山邦宏, 末永重明, 犬童寛子, 佐藤強志, 宮脇正一, 馬嶋秀行
    • Organizer
      第50回日本歯科放射線学会学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ten-m/Odz3 is expressed in chondrogenic process during mandibular fracture healing2009

    • Author(s)
      Fukunaga T, Murakami T, Kobashi N, Kubota T, Tamamura N, Sakai Y, Miyawaki S, Yamashiro T, Takano-Yamanoto T
    • Organizer
      87th IADR
    • Place of Presentation
      マイアミ, USA
    • Related Report
      2009 Annual Research Report
  • [Book] 口と顔の辞典(高戸 毅, ほか編)2008

    • Author(s)
      宮脇正一
    • Publisher
      顎顔面領域の不随意運動.
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 睡眠段階自動判定システム及び睡眠段階自動判定法2008

    • Inventor(s)
      宮脇正一, 永田順子, 上村裕希, 林 列成, 篠崎毅, 千葉伸太郎, 八木朝子, 長濱博行, 城間清美
    • Industrial Property Rights Holder
      鹿児島大学, 株式会社ジー・エム・エス
    • Filing Date
      2008-12-15
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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