| Project/Area Number |
20592407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
MAEDA Aya Kagoshima University, 医歯学総合研究科, 助教 (10457666)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUGUCHI Tetsuya 鹿児島大学, 医歯学総合研究科, 教授 (10303629)
MIYAWAKI Shoichi 鹿児島大学, 医歯学総合研究科, 教授 (80295807)
YOSHIDA Reiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (60244258)
TOMONARI Hiroshi 鹿児島大学, 医歯学総合研究科, 助教 (70398288)
福永 智広 鹿児島大学, 大学院・医歯学総合研究科, 講師 (70362994)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 歯科矯正学 / MyD88 / ケモカイン / 炎症様反応 / 骨芽細胞 / 機械的刺激 |
|---|
| Research Abstract |
In osteoblast isolated from MyD88 knockout mice, chemokine expressions induced by mechanical stress were examined. MyD88 is involved in the gene expression of MIP-2 or MCP-1 and MAP kinase activations by mechanical stresses in osteoblast. These results suggest that MyD88 plays a role not only in immune reactions but also in inflammatory reactions by mechanical stresses and may be important in orthodontic tooth movement.
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