A novel diagnostic method of oral inflammation using salivary myeloperoxidase

• Project/Area Number: 20592445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KANEHIRA Takashi Hokkaido University, 病院, 講師 (90194935)
• Co-Investigator(Kenkyū-buntansha): TAKEHARA Junji 北海道大学, 大学院・歯学研究科, 助教 (60216934) ; MORITA Manabu 岡山大学, 医歯薬学総合研究科, 教授 (40157904)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 唾液 / 口腔炎症 / ミエロペルオキシダーゼ / スクリーニング / 歯周病 / 炎症

Research Abstract

We investigated the relationship between salivary myeloperoxidase (MPO) levels and morbidity in periodontal disease. The results revealed that measuring salivary MPO levels was useful for screening for periodontal disease. Our findings further suggested that quantitative analysis of salivary MPO is of value for assessing the efficacy of initial preparation for treatment of periodontal disease and for detecting inflammatory conditions of the oral cavity, including pericoronitis of the wisdom teeth.

Research Products

• [Journal Article] A pilot study of a simple screening for dry mouth. (2009)
  • Author(s): Kanehira T, Yamaguchi T, Takehara J, Kashiwazaki H,Abe T, Morita M, Asano K, Fujii Y, Sakamoto W
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108 Pages: 389-393
  • Peer Reviewed
• [Journal Article] A pilot study of a simple screening technique for estimation of salivary flow. (2009)
  • Author(s): Kanehira T, et al.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108 Pages: 389-393
  • Peer Reviewed
• [Journal Article] A novel assay system for myeloperoxidase activity in whole saliva. (2008)
  • Author(s): Sakamoto W, Fujii Y, Kanehira T, Asano K, Izumi H
  • Journal Title: Clin Biochem. 41 Pages: 584-90
  • Peer Reviewed
• [Journal Article] A novel assay system for myeloperoxidase activity in whole saliva (2008)
  • Author(s): Sakamoto W and Kanehira T, et.al.
  • Journal Title: Clinical Biochemistry 41 Pages: 584-590
  • Peer Reviewed
• [Presentation] 口腔内科医として必要な唾液検査 (2010)
  • Author(s): 兼平孝
  • Organizer: 第3回日本口腔検査学会総会・学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-09-18
• [Presentation] 口腔内科医として必要な唾液検査 (2010)
  • Author(s): 兼平孝
  • Organizer: 第3回日本口腔検査学会総会・学術大会
  • Place of Presentation: 札幌市(招待講演)
  • Year and Date: 2010-09-18