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A novel diagnostic method of oral inflammation using salivary myeloperoxidase

Research Project

Project/Area Number 20592445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionHokkaido University

Principal Investigator

KANEHIRA Takashi  Hokkaido University, 病院, 講師 (90194935)

Co-Investigator(Kenkyū-buntansha) TAKEHARA Junji  北海道大学, 大学院・歯学研究科, 助教 (60216934)
MORITA Manabu  岡山大学, 医歯薬学総合研究科, 教授 (40157904)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords唾液 / 口腔炎症 / ミエロペルオキシダーゼ / スクリーニング / 歯周病 / 炎症
Research Abstract

We investigated the relationship between salivary myeloperoxidase (MPO) levels and morbidity in periodontal disease. The results revealed that measuring salivary MPO levels was useful for screening for periodontal disease. Our findings further suggested that quantitative analysis of salivary MPO is of value for assessing the efficacy of initial preparation for treatment of periodontal disease and for detecting inflammatory conditions of the oral cavity, including pericoronitis of the wisdom teeth.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] A pilot study of a simple screening for dry mouth.2009

    • Author(s)
      Kanehira T, Yamaguchi T, Takehara J, Kashiwazaki H,Abe T, Morita M, Asano K, Fujii Y, Sakamoto W
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108

      Pages: 389-393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study of a simple screening technique for estimation of salivary flow.2009

    • Author(s)
      Kanehira T, et al.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108

      Pages: 389-393

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel assay system for myeloperoxidase activity in whole saliva.2008

    • Author(s)
      Sakamoto W, Fujii Y, Kanehira T, Asano K, Izumi H
    • Journal Title

      Clin Biochem. 41

      Pages: 584-90

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel assay system for myeloperoxidase activity in whole saliva2008

    • Author(s)
      Sakamoto W and Kanehira T, et.al.
    • Journal Title

      Clinical Biochemistry 41

      Pages: 584-590

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔内科医として必要な唾液検査2010

    • Author(s)
      兼平孝
    • Organizer
      第3回日本口腔検査学会総会・学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔内科医として必要な唾液検査2010

    • Author(s)
      兼平孝
    • Organizer
      第3回日本口腔検査学会総会・学術大会
    • Place of Presentation
      札幌市(招待講演)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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