| Project/Area Number |
20592447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TANDA Naoko Tohoku University, 病院, 助教 (00422121)
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| Co-Investigator(Kenkyū-buntansha) |
KOSEKI Takeyoshi 東北大学, 大学院・歯学研究科, 教授 (80291128)
HINOKIO Yoshinori 東北大学, 大学院・医学系・研究科, 准教授 (10282071)
TAKAHASHI Nobuhiro 東北大学, 大学院・歯学研究科, 教授 (60183852)
WASHIO Jumpei 東北大学, 大学院・歯学研究科, 助教 (20400260)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 予防歯科学 / 糖尿病 / 口内気体 / 二次元評価 / 血糖 / アセトン / 揮発性硫黄化合物 / ケトン体 / 口腔環境 / 呼気 / 口臭 / 口腔内環境 |
|---|
| Research Abstract |
We studied acetone in exhaled air, volatile sulfur compounds and acetone in mouth air, to analyze relation between general condition and oral environment of patients with diabetes mellitus, with healthy volunteers as control. Acetone in exhaled and mouth air of type 2 diabetes patients decreased with improvement of plasma glucose during hospitalization. Study of healthy volunteers with good oral condition showed significantly strong correlation between acetone in exhaled air and acetoacetic acid or 3-hydroxybutyric acid in plasma after fasting overnight. There was no significant correlation between acetone and volatile sulfur compounds. This study suggests possibility that non-invasive acetone measuring indicates ketone bodies in plasma, which reflect pathologic condition of diabetes mellitus.
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