The effect of the serotonergic descending pain inhibitory system activation by acute noticeptive stimulation on chronic notiception in the rats.

• Project/Area Number: 20592448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: ONODERA Dai Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (80312594)
• Co-Investigator(Kenkyū-buntansha): SHOJI Noriaki 東北大学, 病院, 講師 (70250800) ; FUKUMOTO Takahiro 北海道大学, 遺伝子病制御研究所, 助教 (50433024) ; 示野 陽一 東北大学, 病院, 医員 (70447168)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: セロトニン / 下行性疼痛抑制系 / 慢性痛 / 抗うつ剤 / 三叉神経脊髄路核尾側亜核 / 延髄大縫線核

Research Abstract

This study was designed to determine the effect of the serotonergic descending pain inhibitory system activation on chronic pain model rats. Chronic constriction injury (CCI) of the infraorbital nerve (ION) reduced the escape thresholds of mechanical stimulation to the facial area innervated by ION 3-7 days after. Electrical stimulation of mental nerve ipsilaretral to CCI side increased the escape thresholds of mechanical stimulation 12h after. In the same time, expression of serotonin was upregulated in the spinal trigeminal nucleus ipsilateral to stimulus side. These results suggested that the activation of the descending pain inhibitory system by mental nerve stimulation could relieve chronic notiception in ION-CCI model rats.

Research Products

• [Journal Article] Serotonin synthesis and metabolism related molecules in a human prostate cancer cell Line. (2011)
  • Author(s): Shinka T, Onodera D, Tanaka T, Shoji N, Srennie P, Fukumoto T
  • Journal Title: Onco Lett. 2 Pages: 211-215
  • Peer Reviewed
• [Journal Article] Serotonin synthesis and metabolism related molecules in a human prostate cancer cell Line. (2011)
  • Author(s): Shinka T, Onodera D, Tanaka T, Shoji N, Srennie P, Fukumoto T.
  • Journal Title: Onco Lett. Volume: 2 Pages: 211-215
  • Peer Reviewed
• [Journal Article] 咬筋における痛みと浮腫性変化に関する研究 (2010)
  • Author(s): 飯久保正弘、山村宗正、李麗、森士朗、小嶋郁穂、佐藤しづ子、庄司憲明、阪本真弥、笹野高嗣
  • Journal Title: 日本機会学会2010年次大会講演論文集 6 Pages: 165-166
  • Peer Reviewed
• [Journal Article] Dynamic content exchange of serotonin during oocyte maturation. (2010)
  • Author(s): Fukumoto T, Shoji N, Onodera D, Sakurai I, Hirao Y, Tanaka T, Hatamura I
  • Journal Title: JMOR 27 Pages: 216-219
  • Peer Reviewed
• [Journal Article] Dynamic content exchange of serotonin during oocyte maturation. (2010)
  • Author(s): Fukumoto T, Shoji N, Onodera D, Sakurai I, Hirao Y, Tanaka T, Hatamura I
  • Journal Title: Journal of Mammalian Ova Research Volume: 27 Pages: 216-219
  • Peer Reviewed
• [Journal Article] 咬筋における痛みと浮腫性変化に関する研究 (2010)
  • Author(s): 飯久保正弘、山村宗正、李麗、森士朗、小嶋郁穂、佐藤しづ子、庄司憲明、阪本真弥、笹野高嗣
  • Journal Title: 日本機会学会2010年次大会講演論文集 Volume: 6 Pages: 165-166
  • Peer Reviewed
• [Journal Article] The effectiveness of the Uchida-Kraepelin test for psychological stress : an analysis of plasma and salivary stress substances (2009)
  • Author(s): K Sugimoto, A Kanail, N Shoji
  • Journal Title: BioPsychoSocial Med 3
  • Peer Reviewed
• [Journal Article] Hyposalivation strongly influences hypogeusia in the elderly (2009)
  • Author(s): S Satoh-Kuriwada, N Shoji, M Kawai, H Uneyama, N Kaneta, T Sasano
  • Journal Title: Journal of Health Science 55 Pages: 70-74
  • NAID: 130000127955
  • Peer Reviewed
• [Journal Article] Sympathetic nerve fibers sprout into rat odontoblast layer, but not in to dentinal tubules, in response to cavity preparation (2008)
  • Author(s): Shimeno Y, Sugawara Y, Iikubo M, Shoji N, Sasano T
  • Journal Title: Neurosci Lett 435 Pages: 73-77
  • Peer Reviewed
• [Presentation] Quantitative analysis for pain stress using CRH hnRNA expression. (2010)
  • Author(s): Shoji N, Sugimoto K, Kataura T, Onodera D, Sasano T
  • Organizer: 88th International Association for Dental Research
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2010-07-15
• [Presentation] Quantitative analysis for pain stress using CRH hnRNA expression (2010)
  • Author(s): Shoji N, Sugimoto K, Kataura T, Onodera D, Sasano T
  • Organizer: 88th International Association for Dental Research
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2010-07-15
• [Presentation] ラット舌痛刺激による視床下部・下垂体のストレス応答遺伝子転写の定量 (2010)
  • Author(s): 杉本是明、庄司憲明、笹野高嗣
  • Organizer: 第64回日本口腔科学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] 顎顔面領域の痛みが口腔諸組織およびHPA axisに及ぼす影響 (2010)
  • Author(s): 庄司憲明
  • Organizer: 第8回遺伝子病制御研究所 研究交流セミナー
  • Place of Presentation: 札幌
  • Year and Date: 2010-01-28
• [Presentation] 小唾液腺分泌量の測定方法について (2009)
  • Author(s): 庄司憲明, 佐藤しづ子, 飯久保正弘, 古内寿, 阪本真弥, 笹野高嗣
  • Organizer: 第4回Oral Medicine and IVR研究会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-23
• [Presentation] 舌カプサイシン刺激が視床下部-下垂体-副腎系に及ぼす影響-視床下部CRH遺伝子を指標として- (2009)
  • Author(s): 庄司憲明、片浦貴俊、杉本是明、笹野高嗣
  • Organizer: 第3回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 軽井沢
  • Year and Date: 2009-10-04
• [Presentation] Neural bloodflow regulation in rat tongue by chorda-lingual nerve stimulation (2008)
  • Author(s): Noriaki Shoji, Taniguchi Masamitsu, Masahiro Iikubo, Yoichi Shimeno, Takashi Sasano
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] Absence of sympathetic innervation and sprouting in rat dentinal tubules (2008)
  • Author(s): Yoichi Shimeno, Yumiko Sugawara, Masahiro Iikubo, Noriaki Shoji, Takashi Sasano
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-03
• [Presentation] The effect of trigeminal afferent stimulation on HPA axis (2008)
  • Author(s): Kataura T, Sugimoto K, Shoji N, Sasano T
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-03
• [Remarks] ホームページ等