| Project/Area Number |
20602013
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
UNEZAKI Sawako Kansai Medical University, 医学部, 助教 (50257911)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 神経再生 / イメージング / 神経科学 / 疼痛 |
|---|
| Research Abstract |
We created a peripheral nerve regeneration model by using a thy1-YFP transgenic mice, which express a fluorescent protein (YFP) in their sensory/motor neurons. By monitoring sequentially and noninvasively the foot dorsal cutaneous innervation by in vivo fluorescence imaging, we could evaluate the effect of various factors in nerve regeneration. In these factors, we found that Nax, a sodium channel, is functionally coupled to endothelin for lactate release and involves peripheral nerve regeneration.
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