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Mechanisms for methylation imprinting establishment afterfertilization

Research Project

Project/Area Number 20678002
Research Category

Grant-in-Aid for Young Scientists (S)

Allocation TypeSingle-year Grants
Research Field Applied molecular and cellular biology
Research InstitutionUniversity of Tsukuba

Principal Investigator

TANIMOTO Keiji  筑波大学, 生命環境系, 教授 (90261776)

Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥104,000,000 (Direct Cost: ¥80,000,000、Indirect Cost: ¥24,000,000)
Fiscal Year 2012: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2011: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2010: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2009: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2008: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Keywords発現制御 / エピジェネティクス / 遺伝学 / ゲノム / ゲノム刷り込み / トランスジェニックマウス / ダノム / ダノム刷り込み / トランスジェニツクマワス
Research Abstract

enomic imprinting is an epigenetic phenomenon in mammals, in which a subset of genes are mono-allelically expressed depending on their parental origin.To reveal identity of the epigenetic signature discriminating the parental origin and its deposition site within the H19-ICR sequence, transgenic mouse methodology was employed and following findings were demonstrated:
1) Paternal H19-ICR acquired methylation independently of its establishment in sperm
2) CTCF sites were not required to establish paternal-allele-specific methylation in pre-implantation embryos
3) Sequences in the H19-ICR corresponding to the small RNA sequences in oocytes were dispensable for methylation imprinting
4) Differential methylation of the H19-ICR was established by its paternal-allele-specific methylation and maternal-allele-specific protection-against-methylation
5) Oct-sox motif in the H19-ICR harbored protection-against-methylation activity in vivo after implantation
6) Chicken HS4 insulator did not protect the H19-ICR from differential DNA methylation.

Assessment Rating
Verification Result (Rating)

A

Report

(8 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (59 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (36 results) Book (3 results) Remarks (5 results)

  • [Journal Article] The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic Mice2013

    • Author(s)
      Okamura Eiichi
    • Journal Title

      Molecular and Cellular Biology

      Volume: Vol. 33 Issue: 4 Pages: 858-871

    • DOI

      10.1128/mcb.01003-12

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice2012

    • Author(s)
      Takahashi, T., Matsuzaki, H., Tomizawa, S., Okamura, E., Ichiyanagi, T., Fukamizu, A., Sasaki, H. & Tanimoto, K
    • Journal Title

      Gene

      Volume: 508 Issue: 1 Pages: 26-34

    • DOI

      10.1016/j.gene.2012.07.062

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes2011

    • Author(s)
      Campbell, A.D., Cui,S., Shi, L., Urbonya, R., Mathias, A., Bradley, K., Bonsu, K.O., Douglas, R.R., Halford, B., Schmidt, L., Harro, D., Giacherio, D., Tanimoto, K., Tanabeb, O., Engel, J.D.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 46 Pages: 18808-18813

    • DOI

      10.1073/pnas.1104964108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR2010

    • Author(s)
      Matsuzaki, H., Okamura, E., Shimotsuma, M., Fukamizu, A. and Tanimoto, K.
    • Journal Title

      Hum. Mol. Genet

      Volume: 19 Issue: 7 Pages: 1190-8

    • DOI

      10.1093/hmg/ddp589

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR2010

    • Author(s)
      Matsuzaki, H., Okamura, F., Shimotsuma, M., Fukamizu, A., Tanimoto, K.
    • Journal Title

      Hum.Mol.Cenet. 19

      Pages: 1190-1198

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] DNAse I hypersensitivity and epsilon-globin transcriptional enhancement are separable in LCR HS1 mutant human beta-globin YAC transgenic mice2010

    • Author(s)
      Shimotsuma, M., Okamura, E., Matsuzaki, H., Fukamizu, A., Tanimoto, K.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 14495-14503

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouseangiotensinogen promoter activities2010

    • Author(s)
      Oishi, T., Date, S., Shimamoto, Y., Saito, T., Hirota, K., Sugaya, T., Kon, Y., Fukamizu, A., Tanimoto, K.
    • Journal Title

      J.Receptors and Signal Transduction.

      Volume: 30 Pages: 484-492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR2010

    • Author(s)
      Matsuzaki H., Okamura E., Shimotsuma M., Fukamizu A., Tanimoto K.
    • Journal Title

      Hum.Mol.Genet. 19

      Pages: 1190-1198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomly integrated transgenic H19 imprinting control region acquiresmethylation imprinting independently of its establishment in germ cells2009

    • Author(s)
      Matsuzaki, H., Okamura, E., Shimotsuma, M., Fukamizu, A. and Tanimoto, K.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 29 Issue: 17 Pages: 4595-603

    • DOI

      10.1128/mcb.00275-09

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells2009

    • Author(s)
      Matsuzaki, H., Okamura, F., Shimotsuma, M., Fukamizu, A., Tanimoto, K.
    • Journal Title

      Mot.Cell.Biol. 29

      Pages: 4595-4603

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells2009

    • Author(s)
      Matsuzaki H., Okamura E., Shimotsuma M., Fukamizu A., Tanimoto K.
    • Journal Title

      Mol.Cell.Biol. 29

      Pages: 4595-4603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice2009

    • Author(s)
      Okamura E., Matsuzaki H., Campbell A.D., Engel J.D., Fukamizu A., Tanimoto K.
    • Journal Title

      FASEB J. 23

      Pages: 4335-4343

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTCF-dependent enhancer-blocking by alternative chromatin loop formation2008

    • Author(s)
      Hou, C., Zhao, H., Tanimoto, K. and Dean A
    • Journal Title

      Proc. Natl. Acad. Sci. U S A

      Volume: 105 Issue: 51 Pages: 20398-403

    • DOI

      10.1073/pnas.0808506106

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CTCF-dependent enhancer-blocking by alternative chromatin loop formation2008

    • Author(s)
      Hou, C., Zhao, H., Tani moto, K., Dean A.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 105

      Pages: 20398-20403

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] CTCF-dependent enhancer-blocking by alternative chromatin loop formation2008

    • Author(s)
      Hou, C., Zhao, H., Tanimoto, K., Dean A.
    • Journal Title

      Proc Natl Acad. Sci U S A. 105

      Pages: 20398-20403

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The H19 ICR mediates pre-implantation imprinted methylation of nearby sequences in YAC transgenic mice2013

    • Author(s)
      Eiichi Okamura, Hitomi Matsuzaki and Keiji Tanimoto
    • Organizer
      CDB Symposium 2013
    • Place of Presentation
      RIKEN Center for Developmental Biology, Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] The chicken LCR-HS4 insulator does not protect the H19 ICR from imprinted methylation in YAC transgenic mice2012

    • Author(s)
      Keiji Tanimoto
    • Organizer
      18thHemoglobin Switching Conference
    • Place of Presentation
      Monterey, California, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] The H19-ICR bears activities that can introduce imprinted DNA methylation into adjacent, heterologous DNA sequences in YAC transgenic mice2012

    • Author(s)
      Eiichi Okamura, Ryuuta Sakaguchi, Hitomi Matsuzaki and Keiji Tanimoto.
    • Organizer
      Keystone Symposia (Epigenomics)
    • Place of Presentation
      Keystone, Colorado, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Small RNA sequences in the H19-ICR is dispensable for its methylation imprinting inyeast artificial chromosome transgenic mice2012

    • Author(s)
      Takuya Takahashi, Hitomi Matsuzaki, Eiichi Okamura and Keiji Tanimoto
    • Organizer
      Keystone Symposia (Epigenomics)
    • Place of Presentation
      Keystone, Colorado, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] The chicken LCR-HS4 insulator does not protect the H19 ICR from imprinted methylation in YAC transgenic mice2012

    • Author(s)
      K. Tanimoto
    • Organizer
      18^<th> Hemoglobin Switching Conference
    • Place of Presentation
      Monterey, California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] YAC-TgMで見いだしたH19-ICR受精後刷り込みメチル化の解析2012

    • Author(s)
      谷本啓司
    • Organizer
      第26回モロシヌス研究会
    • Place of Presentation
      東京大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] H19-ICRの刷り込みメチル化におけるOct motifのin vivo機能解析2012

    • Author(s)
      坂口龍太, 岡村永一, 谷本啓司
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] H19-ICRの受精後刷り込みメチル化に関わるDNAメチル化酵素の遺伝学的解析2012

    • Author(s)
      松崎仁美, 牛木亜季, 秦健一郎, 谷本啓司
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] The H19-ICR bears activities that can introduce imprinted DNA methylation into adjacent, heterologous DNA sequences in YAC transgenic mice2012

    • Author(s)
      Eiichi Okamura, Ryuuta Sakaguchi, Hitomi Matsuzaki, Keiji Tanimoto
    • Organizer
      Keystone Symposia (Epigenomics)
    • Place of Presentation
      Keystone, Colorado, USA(poster)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Small RNA sequences in the H19-ICR is dispensable for its methylation imprinting in yeast artificial chromosome transgenic mice2012

    • Author(s)
      Takuya Takahashi, Hitomi Matsuzaki, Eiichi Okamura, Keiji Tanimoto
    • Organizer
      Keystone Symposia (Epigenomics)
    • Place of Presentation
      Keystone, Colorado, USA(poster)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヘテロな遺伝子座におけるH19 ICRの受精後刷り込みメチル化解析2011

    • Author(s)
      谷本啓司、松崎仁美、岡村永一、深水昭吉
    • Organizer
      第84回日本内分泌学会学術総会(ミニシンポジウム2 内分泌学におけるエピジェネティクス)
    • Place of Presentation
      神戸国際展示場(口頭)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酵母人工染色体トランスジェニック・マウスを用いたゲノム刷り込みメカニズムの解析2011

    • Author(s)
      谷本啓司
    • Organizer
      日本エピジェネティクス研究会 2011年 第5回年会
    • Place of Presentation
      KKRホテル熊本(口頭)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] H19-ICRは隣接するヘテロなDNA断片を刷り込みメチル化する活性を持つ2011

    • Author(s)
      岡村永一、松崎仁美、坂口龍太、谷本啓司
    • Organizer
      日本エピジェネティクス研究会 2011年 第5回年会
    • Place of Presentation
      KKRホテル熊本(ポスター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of Sox-Oct motif in the establishment of differential methylation at the transgenic H19 ICR2011

    • Author(s)
      坂口龍太、岡村永一、谷本啓司
    • Organizer
      MBSJ2011(第34回日本分子生物学会年会)
    • Place of Presentation
      パシフィコ横浜(ポスター・口頭)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Small RNA sequences in the HI9 ICR are dispensable for its methylation imprinting in YAC transgenic mice2011

    • Author(s)
      高橋拓也、松崎仁美、谷本啓司
    • Organizer
      MBSJ2011(第34回日本分子生物学会年会)
    • Place of Presentation
      パシフィコ横浜(ポスター・口頭)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The chicken HS4 insulator does not protect the H19 ICR from differential methylation in YAC transgenic mice2011

    • Author(s)
      岡村永一、松崎仁美、牛木亜季、谷本啓司
    • Organizer
      MBSJ2011(第34回日本分子生物学会年会)
    • Place of Presentation
      パシフィコ横浜(ポスター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヘテロな遺伝子座におけるH19-ICRの受精後刷り込みメチル化確立機構の解析(Analysis of post-fertilization methylation imprinting at the H19-ICR in YAC transgenic mice)2010

    • Author(s)
      岡村永一、松崎仁美、坂口龍太、谷本啓司
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83同日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートアイランド(口頭・ポスター)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Establishment of imprinted DNA methylation at the transgenic H19 ICR in early mouse embryos2010

    • Author(s)
      H.Matsuzaki, K.Tanimoto
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      Kyusyu University School of Medicine Centennial Hall, Fukuoka, Japan (poster)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ヘテロな遺伝子座に移植したH19 ICRの発生初期胚におけるアリル特異的DNAメチル化の解析(Analysis of allele-specific DNA methylation at the H19 ICR in early embryos of YAC transgenic mice)2010

    • Author(s)
      松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会第4回年会
    • Place of Presentation
      米子市文化ホール、鳥取県米子(ポスター)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ヘテロな遺伝子座におけるH19 ICRメチル化可変領域DMR)形成メカニズムの解析(Analysis of DMR (differentially methylated region) formation at the H19 ICR in YAC transgenic mice)2010

    • Author(s)
      岡村永一、松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会第5回年会
    • Place of Presentation
      米子市文化ホール、鳥取県米子(ポスター)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ヘテロな遺伝子座に移植したH19 ICRの発生初期胚におけるアリル特異的DNAメチル化の解析(ポスター)2010

    • Author(s)
      松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会 2010年第4回年会
    • Place of Presentation
      鳥取県米子市文化ホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヘテロな遺伝子座におけるH19 ICRメチル化可変領域(DMR)形成メカニズムの解析(ポスター)2010

    • Author(s)
      岡村永一、松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会 2010年第4回年会
    • Place of Presentation
      鳥取県米子市文化ホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] The silencing mechanism of the adult β-like globin genes expression in the embryonic erythroid cells of human β-globin YAC transgenic mice (poster)2010

    • Author(s)
      E.Okamura, Andrew D.Campbell, J.D.Engel, K.Tanimoto
    • Organizer
      17th Hemoglobin Switching Conference
    • Place of Presentation
      St.John's College, Oxford, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヘテロな遺伝子座におけるH19-ICRの受精後刷り込みメチル化確立機構の解析(口頭・ポスター)2010

    • Author(s)
      岡村永一、松崎仁美、坂口龍太、谷本啓司
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子導入マウスを用いたゲノム刷り込み確立機構の解析2009

    • Author(s)
      松崎仁美、岡村永一、深水昭吉、谷本啓司
    • Organizer
      日本生化学会関東支部例会「若手が担う次世代型生化学研究」
    • Place of Presentation
      茨城県つくば国際会議場(ポスター)
    • Year and Date
      2009-06-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] YAC遺伝子導入マウスを用いたH19遺伝子刷り込み制御領域の機能解析(ポスター)2009

    • Author(s)
      松崎仁美、深水昭吉、谷本啓司
    • Organizer
      日本生化学会関東支部例会「若手が担う次世代型生化学研究」
    • Place of Presentation
      茨城県 つくば国際会議場
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Post-fertilization methylation imprinting in the randomly integrated transgenic H19-ICR fragment2009

    • Author(s)
      松崎仁美, 谷本啓司
    • Organizer
      epigenetics 2009 ~Australian Scientific Conference~
    • Place of Presentation
      The Sebel, Albert Park, Melbourne, Australia (poster)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Possible role of CTCF binding in the post-fertilization methylation imprinting at the transgenic H19-TCR in beta-globin YAC2009

    • Author(s)
      H.Matsuzaki, K.Tanimoto
    • Organizer
      epigenetics 2010 ~Australian Scientific Conference~
    • Place of Presentation
      The Sebel, Albert Park, Melbourne, Australia (poster)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Post-fertilization methylation imprinting in the randomly integrated transgenic H19-ICR fragment(poster)2009

    • Author(s)
      松崎仁美, 谷本啓司
    • Organizer
      epigenetics 2009~Australian Scientific Conference~
    • Place of Presentation
      The Sebel, Albert Park, Melbourne, Australia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible role of CTCF binding in the post-fertilization methylation imprinting at the transgenic H19-ICR in beta-globin YAC(poster)2009

    • Author(s)
      谷本啓司, 松崎仁美
    • Organizer
      epigenetics 2009~Australian Scientific Conference~
    • Place of Presentation
      The Sebel, Albert Park, Melbourne, Australia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Acquisition of parent-of-origin-specific methylation in the transgenic mouse carrying 2.9-kbp H19 TCR DNA fragment2008

    • Author(s)
      H.Matsuzaki, K.Tanimoto
    • Organizer
      EMBO World Workshop on Genomic Imprinting
    • Place of Presentation
      Temasek Life Science Laboratory, Singapore (oral)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Possible role of CTCF binding in the establishment and/or maintenance of methylation imprinting in the H19 ICR at heterologous beta-globin loci in YAC transgenic mice2008

    • Author(s)
      K.Tanimoto, H.Matsuzaki
    • Organizer
      EMBO World Workshop on Genomic Imprinting
    • Place of Presentation
      Temasek Life Science Laboratory, Singapore(poster)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ヘテロな遺伝子座を用いた刷り込み制御領域の機能解析(Functional analysis of the imprinting control region in the heterologous loci)2008

    • Author(s)
      松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会第2回年会
    • Place of Presentation
      東レ総合研修センター、静岡県三島
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ヘテロな遺伝子座を用いた刷り込み制御領域の機能解析(ポスター)2008

    • Author(s)
      松崎仁美、谷本啓司
    • Organizer
      日本エピジェネティクス研究会2008年第2回年会
    • Place of Presentation
      東レ総合研修センター静岡県三島
    • Related Report
      2008 Annual Research Report
  • [Presentation] Acquisition of parent-of-origin-specific methylation in the transgenic mouse carrying 2.9-kbp H19 ICR DNA fragmen (口頭)2008

    • Author(s)
      H. Matsuzaki and K. Tanimoto
    • Organizer
      EMBO World Workshop on Genomic Imprinting
    • Place of Presentation
      Temasek Life Science Laboratory, Singapore
    • Related Report
      2008 Annual Research Report
  • [Presentation] Possible role of CTCF binding in the establishment and/or maintenance of methylation imprinting in the H19 ICR at heterologous beta-globinloci in YAC transgenic mice (ボスター)2008

    • Author(s)
      K. Tanimoto and H. Matsuzaki
    • Organizer
      EMBO World Workshop on Genomic Imprinting
    • Place of Presentation
      Temasek Life Science Laboratory, Singapore
    • Related Report
      2008 Annual Research Report
  • [Book] メディカル・サイエンス・インターナショナル遺伝情報の発現制御 (Gene Control)転写機構からエピジェネティクスまで第9章 胚発生における遺伝子調節2012

    • Author(s)
      谷本啓司
    • Related Report
      2012 Final Research Report
  • [Book] 日本臨牀RAAS研究の進歩-RAASの新知見-「RAAS遺伝子の転写制御機構-人工染色体導入マウスを用いたin vivo 解析-」(2012年9月号70巻9号)2012

    • Author(s)
      谷本啓司
    • Publisher
      日本臨牀社
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝情報の発現制御(Gene Control)転写機構からエピジェネティクスまで「第9章胚発生における遺伝子調節」(翻訳)2012

    • Author(s)
      谷本啓司
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www1.accsnet.ne.jp/~tanimoto/Keijis/Welcome.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www1.accsnet.ne.jp/~tanimoto/Keijis/Welcome.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://web.me.com/tanik3/Keijis/Welcome.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://web.me.com/tanik3//Keijis/Welcome.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://web.me.com/tanik3/Keijis/Welcome.html

    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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