Neural mechanisms of flexible decision making.

• Project/Area Number: 20680022
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Juntendo University
• Principal Investigator: UKA Takanori Juntendo University, 医学部, 准教授 (50372933)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 運動視 / 立体視 / 大脳皮質 / 連合野 / 視覚 / 神経生理学

Research Abstract

How do we generate flexible decisions? In this study, we recorded neural activity while monkeys performed a task switching paradigm where they randomly switched between two discrimination tasks. We found that sensory neurons are specifically recruited for each task to realize flexible decisions. Our results may be useful not only for understanding the mechanisms underlying flexible decisions, but also for developing brain-machine interfaces that support flexible decisions.

Research Products

• [Journal Article] The spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation. (2010)
  • Author(s): Kumano H, Uka T
  • Journal Title: J Neurophysiol 104 Pages: 61-75
  • Peer Reviewed
• [Journal Article] The spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation. (2010)
  • Author(s): Kumano H, Uka T.
  • Journal Title: J Neurophysiol Volume: 104 Pages: 61-75
  • Peer Reviewed
• [Journal Article] Dynamic readout of behaviorally relevant signals from area MT during task switching. (2009)
  • Author(s): Sasaki R, Uka T
  • Journal Title: Neuron 62 Pages: 147-157
  • Peer Reviewed
• [Presentation] Quantification of direction-speed tuning and its relationship with pattern motion selectivity in macaque area MT. (2010)
  • Author(s): Kumano H, Uka T
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Kobe.
  • Year and Date: 2010-11-03
• [Presentation] Quantification of direction-speed tuning and its relationship with pattern motion selectivity in macaque area MT. (2010)
  • Author(s): Kumano H, Uka T.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Neural mechanisms of flexibility in perceptual decisions. (2009)
  • Author(s): Uka T
  • Organizer: The 57th Annual Meeting of the Japanese Society for Clinical Eletrophysiology of Vision.
  • Place of Presentation: Urayasu.
  • Year and Date: 2009-10-31
• [Presentation] Neural mechanisms of flexibility in perceptual decisions. (2009)
  • Author(s): Uka T
  • Organizer: 第57回日本臨床視覚電気生理学会
  • Place of Presentation: 浦安
  • Year and Date: 2009-10-31
• [Presentation] Change of spatial resolution of direction discrimination : Comparison of MT neuronal and psychophysical performance. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: The 39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago.
  • Year and Date: 2009-10-20
• [Presentation] Change of spatial resolution of direction discrimination : Comparison of MT neuronal and psychophysical performance. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: 39^<th> annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-20
• [Presentation] Spatial resolution of direction discrimination : comparison of MT neuron and behavior. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Nagoya.
  • Year and Date: 2009-09-16
• [Presentation] Spatial resolution of direction discrimination : comparison of MT neuron and behavior. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] A computational model of task switching using leaky integrators. (2009)
  • Author(s): Sasaki R, Uka T
  • Organizer: The 36th International Congress of Physiological Sciences.
  • Place of Presentation: Kyoto.
  • Year and Date: 2009-07-28
• [Presentation] Modeling and testing the receptive field profile of macaque MT neurons. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: The 36th International Congress of Physiological Sciences.
  • Place of Presentation: Kyoto.
  • Year and Date: 2009-07-28
• [Presentation] A computational model of task switching using leaky integrators. (2009)
  • Author(s): Sasaki R, Uka T
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] Modeling and testing the receptive field profile of macaque MT neurons. (2009)
  • Author(s): Kumano H, Uka T
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] A leaky integrator model can account for the time course of MT choice probability during task switching (2008)
  • Author(s): Sasaki R & Uka T
  • Organizer: Society for Neuroscience, 38^<th> Annual Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-19
• [Presentation] Fine spatial resolution of motion direction discrimination of macaque MT neurons in the presence of visual noise. (2008)
  • Author(s): Kumano H, Uka T
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: Washington DC.
  • Year and Date: 2008-11-17
• [Presentation] Fine spatial resolution of motion direction discrimination of macaque MT neurons in the presence of visual noise (2008)
  • Author(s): Kumano H & Uka T
  • Organizer: Society for Neuroscience, 38^<th> Annual Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-17
• [Presentation] Contraction of receptive field size of macaque MT neurons in the presence of visual noise. (2008)
  • Author(s): Kumano H, Uka T
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Tokyo.
  • Year and Date: 2008-07-10
• [Presentation] Spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation. (2008)
  • Author(s): Uka T, Kumano H
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Tokyo.
  • Year and Date: 2008-07-10
• [Presentation] Contraction of receptive field size of macaque MT neurons in the presence of visual noise (2008)
  • Author(s): Kumano H & Uka T
  • Organizer: The 31^<st> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] Spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation (2008)
  • Author(s): Uka T & Kumano H
  • Organizer: The 31^<st> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] A leaky integrator model can account for the time course of MT choice probability during task switching. (2008)
  • Author(s): Sasaki R, Uka T
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: Washington DC.
  • Year and Date: 2008-01-19