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The involvement of brain neurotransmitters on exercise-induced hyperthermia and central fatigue

Research Project

Project/Area Number 20680033
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionHiroshima University

Principal Investigator

HASEGAWA Hiroshi  Hiroshima University, 大学院・総合科学研究科, 准教授 (70314713)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Keywords運動 / 体温調節 / 神経伝達物質 / 視床下部 / 体温調節反応 / 高体温
Research Abstract

We combined in vivo brain microdialysis, biotelemetry and metabolic measurements for continuous monitoring of core body temperature, neurotransmitters and thermoregulatory responses. Using this methodology, we show that the increase in core body temperature, oxygen consumption and tail heat loss during incremental treadmill running is accompanied by an increase in hypothalamic noradrenaline and dopamine release, but without an effect on serotonergic neurotransmission.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (22 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Serotonin release in the preoptic area and anterior hypothalamus is not involved in thermoregulation during low-intensity exercise in a warm environment2010

    • Author(s)
      Satomi Takatsu, Takayuki Ishiwata, Romain Meeusen, Sophie Sarre, Hiroshi Hasegawa.
    • Journal Title

      Neuroscience Letters 482

      Pages: 7-11

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高体温による運動能力の低下と視床下部におけるカテコールアミン2010

    • Author(s)
      長谷川博
    • Journal Title

      体育の科学 60,12

      Pages: 812-818

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serotonin release in the preoptic area and anterior hypothalamus is not involved in thermoregulation during low-intensity exercise in a warm environment2010

    • Author(s)
      Takatsu S, Ishiwata T, Meeusen R, Sarre S, Hasegawa H.
    • Journal Title

      Neuroscience Letters

      Volume: 482 Pages: 7-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高体温による運動能力の低下と視床下部におけるカテコールアミン2010

    • Author(s)
      長谷川博
    • Journal Title

      体育の科学

      Volume: 60 Pages: 812-818

    • Related Report
      2010 Annual Research Report
  • [Presentation] Thermoregulatory responses and hypothalamic catecholamines during incremental running in rats.2011

    • Author(s)
      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Hideto Tanaka.
    • Organizer
      第88回日本生理学会大会誌上発表,P2-341
    • Related Report
      2010 Final Research Report
  • [Presentation] The influence of warm ambient temperature on thermoregulation and extracellular monoamines in the preoptic area and anterior hypothalamus in exercising rats.2011

    • Author(s)
      Satomi Takatsu, Takayuki Ishiwata, Hiroshi Hasegawa.
    • Organizer
      第88回日本生理学会大会誌上発表,P2-341
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of serotonin in the ventral tegmental area on thermoregulation of freely moving rats.2011

    • Author(s)
      Takayuki Ishiwata, Satomi Takatsu, Hiroshi Hasegawa, Sigeki Nomoto.
    • Organizer
      第88回日本生理学会大会誌上発表,P2-341
    • Related Report
      2010 Final Research Report
  • [Presentation] The effect of ambient temperature on thermoregulation and extracellular monoamines in the preoptic area and anterior hypothalamus in exercising rats2010

    • Author(s)
      Takatsu S, Ishiwata T, Meeusen R, Sarre S, Hasegawa H.
    • Organizer
      13^<th> International Conference on In Vivo Methods : Monitoring Molecules in Neuroscience
    • Place of Presentation
      Brussels (Belgium)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 視床下部におけるカテコールアミンの増大により運動時の体温調節反応は亢進する2010

    • Author(s)
      長谷川博, 高津理美, 石渡貴之, 田中英登
    • Organizer
      第65回日本体力医学会
    • Place of Presentation
      和洋女子大学(市川市)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of ambient temperature on thermoregulation and extracellular monoamines in the preoptic area and anterior hypothalamus in exercising rats2010

    • Author(s)
      Satomi Takatsu, Takayuki Ishiwata, Romain Meeusen, Sophie Sarre, Hiroshi Hasegawa.
    • Organizer
      13th International Conference on In Vivo Methods : Monitoring Molecules in Neuroscience
    • Place of Presentation
      Brussels, Belgium.
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 視床下部におけるカテコールアミンの増大により運動時の体温調節反応は亢進する2010

    • Author(s)
      長谷川博, 高津理美, 石渡貴之, 田中英登
    • Organizer
      第65回日本体力医学会
    • Place of Presentation
      市川市
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] スポーツ活動時における暑さ対策2010

    • Author(s)
      長谷川博, 高津理美
    • Organizer
      第149回日本体力医学会関東地方会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Body temperature regulation and hypothalamic catecholamines during incremental running in rats.2010

    • Author(s)
      Hiroshi Hasegawa, Satomi Takatsu, Takayuki Ishiwata, Romain Meeusen.
    • Organizer
      American College of Sports Medicine, 57th Annual Meeting, S466
    • Place of Presentation
      Baltimore, U.S.A.
    • Year and Date
      2010-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] スポーツ活動時における暑さ対策2010

    • Author(s)
      長谷川博, 高津理美
    • Organizer
      第149回日本体力医学会関東地方会
    • Place of Presentation
      横浜国立大学(横浜市)(招待講演)
    • Year and Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 暑熱環境下における運動時の体温調節中枢機構2010

    • Author(s)
      長谷川博
    • Organizer
      第62回日本生理人類学会
    • Place of Presentation
      大阪国際大学(守口市)(招待講演)
    • Year and Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 暑熱環境下における運動時の体温調節中枢機構2010

    • Author(s)
      長谷川博
    • Organizer
      第62回日本生理人類学会
    • Place of Presentation
      守口市(招待講演)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional role of extracellular serotonin in the PO/AH in thermoregulation during exercise.2009

    • Author(s)
      Satomi Takatsu, Takayuki Ishiwata, Sigeru Nomoto, Hiroshi Hasegawa.
    • Organizer
      Neuroscience 2009, 274.17
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2009-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional role of extracellular serotonin in the PO/AH in therm oregulation during exercise2009

    • Author(s)
      Satomi Takatsu
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      McCormick Place convention center (Chicago, USA)
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 漸増負荷運動時における体温調節反応及び脳内神経伝達物質の測定-無麻酔・無拘束動物実験から得られるものとは?-2009

    • Author(s)
      長谷川博
    • Organizer
      第2回脳・神経・内分泌系から運動の意義を考える会
    • Place of Presentation
      新潟コンベンションセンター(新潟市)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 漸増負荷運動時における体温調節反応及び脳内神経伝達物質の測定-無麻酔・無拘束動物実験から得られるものとは?-2009

    • Author(s)
      長谷川博, 高津理美
    • Organizer
      第2回脳・神経・内分泌系から運動の意義を考える会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動時の中枢性疲労および温熱疲労における脳内神経伝達物質の関与2009

    • Author(s)
      長谷川博
    • Organizer
      第17回日本運動生理学会(シンポジスト)
    • Place of Presentation
      港区
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Thermoregulatory responses of exercising rats in the warm environment are not influenced by increased extracellular serotonin in the PO/AH.2009

    • Author(s)
      Satomi Takatsu, Takayuki Ishiwata, Keisuke Bajyo, Romain Meeusen, Hiroshi Hasegawa.
    • Organizer
      Proceedings of the 3rd International Symposium on Physiology and Pharmacology of Thermoregulation, pg152
    • Place of Presentation
      出雲市
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Comparison of the VMH, DMH and PH in thermoregulation of freely moving rats.2009

    • Author(s)
      Ishiwata T, Hasegawa H, Saito T, Nomoto S, Aihara Y.
    • Organizer
      Proceedings of the 3rd International Symposium on Physiology and Pharmacology of Thermoregulation. Izumo, Japan, pg96
    • Place of Presentation
      出雲市
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 運動時の中枢性疲労および温熱疲労における脳内神経伝達物質の関与2009

    • Author(s)
      長谷川博
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thermoregulatory responses of exercising rats in the warm environment are not influenced by increased extracellular serotonin in the PO/AH2009

    • Author(s)
      Satomi Takatsu
    • Organizer
      The 3^<rd> International Symposium on Physiology and Pharmacology of Thermoregulation
    • Place of Presentation
      島根県立産業交流会館(松江市)
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of the VMH, DMH and PH in thermoregulation of freely moving rats2009

    • Author(s)
      Takayuki Ishiwata
    • Organizer
      The 3^<rd> International Symposium on Physiology and Pharmacology of Thermoregulation
    • Place of Presentation
      島根県立産業交流会館(松江市)
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Book] 運動時の体温上昇とその影響2010

    • Author(s)
      長谷川博
    • Publisher
      ナップ
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] 運動と体温-中枢調節-2010

    • Author(s)
      長谷川博
    • Publisher
      真興交易
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] 運動の限界-体温と疲労-2010

    • Author(s)
      長谷川博
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://home.hiroshima-u.ac.jp/hasehiro/index.html6

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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