| Budget Amount *help |
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
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| Research Abstract |
The I-BAR domain of IRSp53 deforms plasma membrane into protrusion through its binding of its convex surface to the inner surface of tubular protrusions. In contrast, the F-BAR domain of pacsin2 deforms plasma membrane at the neck of the protrusions, where orthogonal membrane curvature is formed by the concave surface of the F-BAR domain. These two modes of plasma membrane deformation are thought to be important for cellular protrusions including podosome for cancer cell invasion.
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