The methylation of non-histone proteins in bone diseases
| Project/Area Number |
20689007
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOGA Takako Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 客員助教 (90451905)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 生体分子医学 / 骨代謝疾患 / 転写因子 / 翻訳後修飾 / 破骨細胞 / タンパク質メチル化酵素 / 翻訳語修飾 |
|---|
| Research Abstract |
We generated and analyzed PRMT5 conventional knockout (KO) mice and osteoclast-specific conditional KO (cKO) mice. PRMT5 homo KO mice died in uterus at the very early stage of embryo development. PRMT5 hetero KO mice spontaneously developed tumor in various organs. These suggested that PRMT5 had role a non-redundant role in development and tumorigenesis. On the other hand, osteoclast-specific PRMT5 cKO mice exhibited normal skeletal development and bone volume, suggesting that other member of Type II PRMT family, PRMT7 may compensated the lack of PRMT5 in osteoclastogenesis.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Role of septins in the orientation of forespore-membrane extension during sporulation in fission yeast.2010
Author(s)
Masayuki Onishi, Takako Koga, Aiko Hirata, Taro Nakamura, Haruhiko Asakawa, Chikashi Shimoda, Jurg Bahler, Jian-Qiu Wu, Kaoru Takegawa, Hiroyuki Tachikawa, John R.Pringle, Yasuhisa Fukui.
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Journal Title
Mol.Cell.Biol. 30(8)
Pages: 2059-2074
Related Report
Peer Reviewed
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[Journal Article] Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.2009
Author(s)
Baohong Zhao, Masamichi Takami, Atsushi Yamada, Xiaogu Wang, Takako Koga, Xiaoyu Hu, Tomohiko Tamura, Keiko Ozato, Yongwon Choi, Lionel B Ivashkiv, Hiroshi Takayanagi, Ryutaro Kamijo.
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Journal Title
Nature Medicine. 15(9)
Pages: 1066-1071
Related Report
Peer Reviewed
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[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.2008
Author(s)
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T.
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Journal Title
J Immunol. 181(7)
Pages: 4742-4751
Related Report
Peer Reviewed
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[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
Author(s)
Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S.Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier, Hiroshi Takayanagi.
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Journal Title
Cell. 132(5)
Pages: 794-806
Related Report
Peer Reviewed
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[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.2008
Author(s)
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
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Journal Title
J Immunol 181
Pages: 4742-4751
Related Report
Peer Reviewed
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[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008
Author(s)
Shiohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
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Journal Title
Related Report
Peer Reviewed
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