Analysis of Drosophila dPQBP1 mutant

• Project/Area Number: 20700285
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAMURA Takuya Tokyo Medical and Dental University, 難治疾患研究所, 助教 (80396647)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ショウジョウバエ / 記憶 / 学習 / 精神遅滞 / モデル動物 / PQBP1 / projection neuron / 学習・記憶 / 行動生理学 / 神経回路 / 行動遺伝学

Research Abstract

We analyzed the dPQBP1 mutant to elucidate the cause of the inhibited learning acquisition of the dPQBP1 mutant. The dPQBP1 mutant has a defect in projection neurons but not in mushroom bodies (which is a target of projection neuron and which is considered to be center of memory). The defect was considered to be functional but not morphological (and/or developmental). It was suggested that the defect is depends on reduced expression of NMDA receptor in projection neurons.

Research Products

• [Journal Article] These authours equally contribute Mutant huntingtin impairs Ku70-mediated DNA repair. (2010)
  • Author(s): Enokido Y*, Tamura T*, Ito H*, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H
  • Journal Title: J Cell Biol. 189(3) Pages: 425-43
• [Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. (2009)
  • Author(s): Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y
  • Journal Title: PLoS One 4(2)
  • Peer Reviewed
• [Journal Article] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models. (2009)
  • Author(s): Tamura T, Sone M, Yamashita M, Wanker EE, Okazawa H
  • Journal Title: PLoS One 4(1)
  • Peer Reviewed
• [Journal Article] Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models (2009)
  • Author(s): Tamura T, Sone M, Yamashita M, Wanker EE, Okazawa H.
  • Journal Title: Plos ONE 4(1)
  • Peer Reviewed
• [Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening (2009)
  • Author(s): Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y.
  • Journal Title: Plos ONE 4(2)
  • Peer Reviewed
• [Presentation] ショウジョウバエPQBP1とprojection neuron と学習障害 (2009)
  • Author(s): 田村拓也
  • Organizer: 第2回分子高次機能研究会
  • Place of Presentation: いわき(福島)
  • Year and Date: 2009-11-03
• [Presentation] Glial cell lineage of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models (2009)
  • Author(s): 田村拓也、曽根雅紀、山下真弓、岡澤均
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 新規精神遅滞モデルショウジョウバエ、PQBP1変異体の行動遺伝学的解析 (2009)
  • Author(s): 田村拓也
  • Organizer: CBIR若手シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-02-01
• [Presentation] ショウジョウバエPQBP1とprojection neuronと学習障害 (2009)
  • Author(s): 田村拓也
  • Organizer: 第2回分子高次機能研究会
  • Place of Presentation: 福島(いわき)
• [Presentation] 転写抑制による緩慢な非典型的細胞死(TRIAD)の分子経路の解明;ショウジョウバエモデルの作成と解析 (2008)
  • Author(s): 田村拓也
  • Organizer: 細胞死病コロキウム
  • Place of Presentation: 京都
  • Year and Date: 2008-10-21
• [Presentation] Ultra-short memory stored in projection neurons requires a novel memory gene, drosophila PQBP1. ショウジョウバエPQBP1はプロジェクションニューロンに保持される超短期記憶に必須である (2008)
  • Author(s): 田村拓也、堀内大輔、曽根雅紀、Yi-Chung Chen, Ann-Shyn Chiang, 岡澤均
  • Organizer: 第31回日本神経科学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] Ultra-short memory stored in projection neurons requires a novel memory gene, drosophila PQBP1 (2008)
  • Author(s): 田村拓也、堀内大輔、曽根雅紀、Yi-Chung Chen, Ann-Shyn Chiang, 岡澤均
  • Organizer: 第31回日本神経科学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] PQBP-1遺伝子変異による精神遅滞の新たなモデルショウジョウバエ (2008)
  • Author(s): 田村拓也、堀内大輔、曽根雅紀、岡澤均
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] ショウジョウバエPQBP1はprojection neuronに保持される超短期記憶に必須である (2008)
  • Author(s): 田村拓也
  • Organizer: 第1回分子高次機能研究会
  • Place of Presentation: 山梨