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Analysis for the roles of endocytosis in neuronal migration and morphological changes during cerebral cortical development

Research Project

Project/Area Number 20700317
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionKeio University

Principal Investigator

KAWAUCHI Takeshi  Keio University, 医学部, 講師 (60397544)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経発生 / 分化 / 異常 / 大脳皮質 / マウス / 神経細胞移動 / Dynamin / Cdk5
Research Abstract

Neuronal migration has essential roles for cerebral cortical development. Although many studies have focused on the important roles of cytoskeletal proteins, the requirement of membrane trafficking-related proteins has remained unclear. In this study, we revealed that Dynamin, a central regulator for endocytosis, is involved in cortical neuronal migration in vivo.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2011 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (29 results) Remarks (4 results)

  • [Journal Article] Regulation of cell adhesion and migration in cortical neurons : not only Rho but also Rab family small GTPases2011

    • Author(s)
      Kawauchi T.
    • Journal Title

      Small GTPases Vol.2(1) in press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of cell adhesion and migration in cortical neurons : not only Rho but also Rab family small GTPases2011

    • Author(s)
      Kawauchi T
    • Journal Title

      Small GTPases

      Volume: 2 Pages: 36-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth2010

    • Author(s)
      Eto K, Kawauchi T, Osawa M, Tabata H, Nakajima K.
    • Journal Title

      Neurosci. Res. Vol.66(1)

      Pages: 37-45

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth2010

    • Author(s)
      Eto K, Kawauchi T, Osawa M, Tabata H, Nakajima K.
    • Journal Title

      Neurosci. Res. 66

      Pages: 37-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac is involved in the interkinetic nuclear migration of cortical progenitor cells'2009

    • Author(s)
      Minobe S, Sakakibara A, Ohdachi T, Kanda R, Kimura M, Nakatani S, Tadokoro R, Ochiai W, Nishizawa Y, Mizoguchi A, Kawauchi T, Miyata T.
    • Journal Title

      Neurosci. Res. Vol.63(4)

      Pages: 294-301

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞内現象からみた大脳皮質形成のメカニズム-"in vivo細胞生物学"による神経発生研究の展開-2008

    • Author(s)
      川内健史
    • Journal Title

      蛋白質核酸酵素 53

      Pages: 1957-1967

    • NAID

      40016350944

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac is involved in the interkinetic nuclear migration of cor tical progenitor cells2008

    • Author(s)
      Minobe S, Sakakibara A, Ohdachi T, Kanda R, Kimura M, Nakatani S, Tadokoro R, Ochiai W, Nishizawa Y, Mizoguchi A, Kawauchi T, Miyata T.
    • Journal Title

      Neurosci. Res 63

      Pages: 294-301

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 発生期大脳皮質における神経細胞の移動と成熟の分子機構2010

    • Author(s)
      川内健史
    • Organizer
      神戸大学大学院医学研究科大学院講義
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 発生期大脳皮質における神経細胞の移動と成熟の分子機構2010

    • Author(s)
      川内健史
    • Organizer
      神戸大学大学院医学研究科 大学院講義
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo細胞生物学による神経細胞移動のメカニズムの解明2010

    • Author(s)
      川内健史
    • Organizer
      第28回脳科学グローバルCOE若手フォーラム
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo細胞生物学による神経細胞移動のメカニズムの解明2010

    • Author(s)
      川内健史
    • Organizer
      第28回 脳科学グローバルCOE 若手フォーラム
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular and cellular mechanisms for the radial glial fiber-dependent locomotion mode of cortical neuronal migration2010

    • Author(s)
      Takeshi Kawauchi
    • Organizer
      Global COE Liaison Laboratory regular seminar
    • Place of Presentation
      Kumamoto University, Kumamoto, Japan.
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular and cellular mechanisms for the radial glial fiber-dependent locomotion mode of cortical neuronal migration2010

    • Author(s)
      Takeshi Kawauchi
    • Organizer
      Global COE Liaison Laboratory regular seminar
    • Place of Presentation
      熊本
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] エンドサイトーシス経路によるN-カドヘリンの細胞内輸送を介した神経細胞移動の制御機構2010

    • Author(s)
      川内健史、関根克敏、鹿内弥磨、富田憲司、久保健一郎、鍋島陽一、星野幹雄、仲嶋一範
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)、一般口頭発表「細胞の構造と機能/Cell Biology」
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質形成過程におけるRap1依存的な神経細胞移動の局面2010

    • Author(s)
      関根克敏、川内健史、久保健一郎、本田岳夫、仲嶋一範
    • Organizer
      第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Molecular mechanisms of Reelin-Dab1 signaling in the mammalian neocortical development2010

    • Author(s)
      Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao Honda, Kazunori Nakajima
    • Organizer
      Global COE program Center for Human Metabolomic Systems Biology Workshop
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] エンドサイトーシス経路によるN-カドヘリンの細胞内輸送を介した神経細胞移動の制御機構2010

    • Author(s)
      川内健史、関根克敏、鹿内弥磨、富田憲司、久保健一郎、鍋島陽一、星野幹雄、仲嶋一範
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanisms of Reelin-Dab1 signaling in the mammalian neocortical development2010

    • Author(s)
      Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao Honda, Kazunori Nakajima
    • Organizer
      Global COE program Center for Human Metabolomic Systems Biology Workshop
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大脳皮質形成の分子機構の解明に向けた"in vivo細胞生物学"的アプローチ2009

    • Author(s)
      川内健史
    • Organizer
      名古屋大学大学院医学研究科基礎医学特論;名古屋大学大学院医学研究科
    • Place of Presentation
      愛知
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質形成の分子機構の解明に向けた"in vivo細胞生物学"的アプローチ2009

    • Author(s)
      川内健史
    • Organizer
      名古屋大学大学院医学研究科基礎医学特論
    • Place of Presentation
      名古屋大学大学院医学研究科、愛知
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞骨格関連分子による神経細胞の移動と形態変化の制御2009

    • Author(s)
      川内健史
    • Organizer
      2008年度発達障害研究所共同セミナー;愛知県心身障害者コロニー発達障害研究所
    • Place of Presentation
      愛知
    • Year and Date
      2009-01-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞骨格関連分子による神経細胞の移動と形態変化の制御2009

    • Author(s)
      川内健史
    • Organizer
      2008年度発達障害研究所共同セミナー
    • Place of Presentation
      愛知県心身障害者コロニー発達障害研究所
    • Year and Date
      2009-01-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大脳皮質2/3層錐体細胞の放射状移動を制御する新たなカルシウムエフェクターCaMKIαの機能解明2009

    • Author(s)
      安達-森島亜希, 竹本-木村さやか, 鈴木敢三, 上田(石原)奈津実, 野中美応, 岡村理子, 西村嘉晃, 川内健史, 仲嶋一範, 奥野浩行, 尾藤晴彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] A pivotal role of a CaMKK-Ca2+/calmodulin-dependent protein kinase I cascade in the radial migration of layer 2/3 cortical pyramidal neurons2009

    • Author(s)
      Takemoto-Kimura S., Adachi-Morishima A., Ageta-Ishihara N., Suzuki K., Nonaka M., Okamura M., Nishimura Y.V., Kawauchi T., Nakajima K., Okuno H., Bito H.
    • Organizer
      Society for Neuroscience, Neuroscience 2009 Mceting (39th Annual Mceting)
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Cdk5-p27^<kip1> pathway in cortical neuronal migration and morphological changes2009

    • Author(s)
      Takeshi Kawauchi
    • Organizer
      平成21年度二国間交流事業協同セミナー「Cdk5 International Symposium」
    • Place of Presentation
      Tokyo Metropolitan University, Tokyo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Cdk5-p27^<kip1> pathway in cortical neuronal migration and morphological changes2009

    • Author(s)
      Takeshi Kawauchi
    • Organizer
      2^<nd> Cdk5 International Symposium
    • Place of Presentation
      首都大学、東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大脳皮質2/3層錐体細胞の放射状移動を制御する新たなカルシウムエフェクターCaMKIαの機能解明2009

    • Author(s)
      安達一森島亜希, 竹本一木村さやか, 鈴木敢三, 上田(石原), 奈津実, 野中美応, 岡村理子, 西村嘉晃, 川内健史, 仲嶋一範, 奥野浩行, 尾藤晴彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場など、神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] A pivotal role of a CaMKK-Ca2+/calmodulin-dependent protein kinase I caseade in the radial migration of layer 2/3 cortical pyramidal neurons2009

    • Author(s)
      Tahemoto-Kimura S., Adachi-Morishima A., Ageta-lshihara N., Suzuki K., Nonaka M., Okamura M., Nishimura Y.V., Kawauchi T., Nakajima K., Okuno H., Bito H.
    • Organizer
      Society for Neuroscience, Neuroscience 2009 Meeting (39th Annual Meeting)
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo cell biology for cerebral cortical development2008

    • Author(s)
      Takeshi Kawauchi
    • Organizer
      RIKEN BSI (Brain Science Institute) Informal Seminar
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2008-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo cell biology for cerebral cortical development2008

    • Author(s)
      Kawauchi T
    • Organizer
      RIKEN BSI Informal Seminar
    • Place of Presentation
      理研BSI(東京都)
    • Year and Date
      2008-10-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経細胞特異的な移動様式であるロコモーション移動を制御する分子機構の解析2008

    • Author(s)
      西村嘉晃、仲嶋一範、鍋島陽一、星野幹雄、川内健史
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemical inhibitor screening for molecules regulating morphological changes of locomoting neurons in the developing cerebral cortex2008

    • Author(s)
      Yoshiaki V.Nishimura, Kazunori Nakajima, Yo-ichi Nabeshima, Mikio Hoshino, Takeshi Kawauchi
    • Organizer
      第50回日本神経化学会大会、Oral Session「軸索輸送、細胞運動、細胞骨格」
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report
  • [Presentation] Search for molecules regulating morphological changes of migrating neurons using real-time imaging of cortical slices2008

    • Author(s)
      Yoshiaki V.Nishimura, Kazunori Nakajima, Mikio Hoshino, Yo-ichi Nabeshima, Takeshi Kawauchi
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Possible involvement of Cdk5 and JNK in the migration and morphological changes of locomoting neurons during cerebral co rtical development2008

    • Author(s)
      Nishimura YV, Nakajima K, N abeshima YI, Hoshino M, Kaw auchi T
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical inhibitor screening for molecules regulating morpho logical changes of locomoting neurons in the developing cere bral cortex2008

    • Author(s)
      Nishimura YV, Nakajima K, N abeshima YI, Hoshino M, Kaw auchi T
    • Organizer
      第50回日本神経化学会大会
    • Place of Presentation
      富山県
    • Related Report
      2008 Annual Research Report
  • [Presentation] Search for molecules regulating morphological changes of mig rating neurons using real-time imaging of cortical slices2008

    • Author(s)
      Nishimura YV, Nakajima K, oshino M, Nabeshima YL Kaw auchi T
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://web.sc.itc.keio.ac.jp/anatomy/nakajima/page10/page17/page17.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/anatomy/nakajima/page10/page17/page17.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/anatomy/nakajima/page10/page17/page17.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/anatomy/nakajima/index.htm

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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