| Project/Area Number |
20700329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHIDA Tomoyuki The University of Tokyo, 大学院・医学系研究科, 講師 (90372367)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 発生 / 分化 / 老化 / シナプス形成 / 軸索終末分化 / ゼブラフィッシュ / 嗅神経細胞 / カルシウム / シナプス小胞 / IP3 / カルシウムチャンネル / 軸索終末 / 精神遅滞 / ILIRAPL1 / 原因遺伝子 |
|---|
| Research Abstract |
Functional screening of transmembrane proteins for their role in presynaptic differentiation of zebrafish olfactory sensory neurons identified IL1RAPL1. We demonstrated that zebrafish orthologue of mammalian IL1RAPL1, Il1rapl 1b, played an important role in axon terminal differentiation by regulating synaptic vesicle accumulation and morphological remodeling. We also showed that IP3-mediated Ca2+/calmodulin signaling stimulates synaptic vesicle accumulation and subsequent neuronal activity-dependent Ca2+/calmodulin signaling induces the morphological remodeling of axon terminals of zebrafish olfactory sensory neurons.
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