| Project/Area Number |
20700401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
NAKANISHI Jun National Institute for Materials Science, 国際ナノアーキテクトニクス研究拠点, 独立研究者 (60360608)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | バイオマテリアル / 再生医療 / コラーゲン / パターニング / ケージド化合物 / ポリエチレングリコール / 細胞 / 高分子 |
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| Research Abstract |
In this study, I have developed a method for reversible modification of the surface properties of bio-oriented scaffolds by using a molecule that can be once conjugated but cleaved in response to light. As a proof of concept, I demonstrated a reversible modification of an amino-terminated surface with poly(ethylene glycol) and control of its cell adhesiveness. In addition, I have succeeded in the control of the activity of biological amine and the formation of surface chemical gradients on gold nanoparticles and substrates based on the similar strategy.
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