Tissue engineering based on reversible modification of bio-oriented scaffolds
| Project/Area Number |
20700401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
NAKANISHI Jun National Institute for Materials Science, 国際ナノアーキテクトニクス研究拠点, 独立研究者 (60360608)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | バイオマテリアル / 再生医療 / コラーゲン / パターニング / ケージド化合物 / ポリエチレングリコール / 細胞 / 高分子 |
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| Research Abstract |
In this study, I have developed a method for reversible modification of the surface properties of bio-oriented scaffolds by using a molecule that can be once conjugated but cleaved in response to light. As a proof of concept, I demonstrated a reversible modification of an amino-terminated surface with poly(ethylene glycol) and control of its cell adhesiveness. In addition, I have succeeded in the control of the activity of biological amine and the formation of surface chemical gradients on gold nanoparticles and substrates based on the similar strategy.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Precise patterning of photoactivatable glass coverslip for fluorescence observation of shape-controlled cells2010
Author(s)
J.Nakanishi, Y.Kikuchi, Y.Tsujimura, H.Nakayama, S.Kaneko, T.Shimizu, H.Yokota, K.Yamacughi, Y.Yoshida, T.Takarada, M.Maeda, Y.Horiike
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Journal Title
Supramolecular Chemistry (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Precise patterning of photoactivatable glass coverslip for fluorescence observation of shape-controlled cells
Author(s)
J. Nakanishi, Y. Kikuchi, Y. Tsujimura, H. Nakayama, S. Kaneko, T. Shimizu, H. Yokota, K. Yamacughi, Y. Yoshida, T. Takarada, M. Maeda, Y. Horiike
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Journal Title
Supramolecular chemistry (in press)
Related Report
Peer Reviewed
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