Role of circadian clock in regulation of metabolic syndrome onset by food factor

• Project/Area Number: 20700595
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Osaka City University
• Principal Investigator: FUKUMURA Tomoe Osaka City University, 大学院・生活科学研究科, 講師 (80336792)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 健康と食生活 / 食品因子 / メタボリック症候群 / 体内時計

Research Abstract

The aim of the present study was to examine the molecular mechanism of the metabolic syndrome onset by the disruption of circadian clock. Experiments were carried out on metabolic syndrome model rats under various conditions. As a result, there were significant difference in some clock gene expression between control and metabolic syndrome model rats. These findings suggest the possibility that these genes regulate onset of metabolic syndrome.

Research Products

• [Journal Article] Ge netic Interaction between Hyperglycemic QTL s is Manifested under a High Calorie Diet in OLETF-Derived Congenic rats. (2011)
  • Author(s): T Fukumura, H Kose, C Takeda, Y Kurita, K Ochiai, T Yamada, K Matsumoto.
  • Journal Title: Experimental Animals Vol.60 Pages: 125-132
  • Peer Reviewed
• [Journal Article] Genetic Interaction between Hyperglycemic QTLs is Manifested under a High Calorie Diet in OLETF-Derived Congenic rats. (2011)
  • Author(s): T Fukumura, H Kose, C Takeda, et.al.
  • Journal Title: Experimental Animals Volume: 60 Pages: 125-132
  • Peer Reviewed
• [Journal Article] The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/b-catenin signaling pathway. (2010)
  • Author(s): YH Jeong, M Sekiya, M Hirata, M Ye, A Yamagishi, SM Lee, MJ Kang, A Hosoda, T Fukumura, DH Kim, S Saeki.
  • Journal Title: Biochemical and Biophysical Research Communications Vol.392 Pages: 495-499
  • Peer Reviewed
• [Journal Article] Molecular charact erization and expression of the low-density lipoprotein receptor-related protein-10 (2010)
  • Author(s): YH Jeong, K Ishikawa, Y Someya, A Hos oda, T Yoshimi, C Yokoyama, S Liryu-seo, MJ Kang, T tachibana, H Kiyama, T Fukum ura, DH Kim, S Saeki.
  • Journal Title: a new member of the LDLR gene family Biochemical and Biophysical Research Communications Vol.391 Pages: 1110-1115
  • Peer Reviewed
• [Journal Article] Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family (2010)
  • Author(s): YH Jeong, K Ishikawa, Y Someya, et. al.
  • Journal Title: Biochemical and Biophysical Research, Communications 391 Pages: 1110-1115
  • Peer Reviewed
• [Journal Article] The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/b-catenin signaling pathway (2010)
  • Author(s): YH Jeong, M Sekiya, M Hirata, et. al.
  • Journal Title: Biochemical and Biophysical Research Communications 392 Pages: 495-499
  • Peer Reviewed
• [Presentation] メタボリック症候群モデル動物OLETFラットの脂質代謝関連遺伝子の変異解析 (2010)
  • Author(s): 篠木絵美子, 叶明娟, 山本哲朗, 栗原由佳, 山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 日本栄養食糧学会・第49回近畿支部会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2010-10-16
• [Presentation] メタボリック症候群モデル動物OLETFラットの脂質代謝関連遺伝子の変異解析 (2010)
  • Author(s): 篠木絵美子、叶明娟、山本哲朗, 他
  • Organizer: 日本栄養食糧学会・第49回近畿支部会
  • Place of Presentation: 大阪府大阪市立大学
  • Year and Date: 2010-10-16
• [Presentation] リポ蛋白質受容体ファミリーによる-wnt/カテニンシグナル伝達経路の阻害機構 (2009)
  • Author(s): 平田倫子, 関家麻奈未, 丁英姫, 山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎新聞文化ホール
  • Year and Date: 2009-05-22
• [Presentation] メタボリック症候群モデル動物における体内時計遺伝子と脂質代謝関連遺伝子の発現解析 (2009)
  • Author(s): 叶明娟, 山本哲朗, 金哲民, 細田明美, 内田友乃, 池田彩子, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎新聞文化ホール
  • Year and Date: 2009-05-22
• [Presentation] リポ蛋白質レセプターファミリーLRP10はWnt/b-catenin経路のシグナル伝達を制御する (2009)
  • Author(s): 平田倫子, 関家麻奈未, 丁英姫, 山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 日本農芸化学学会2009年度大会
  • Place of Presentation: 福岡マリンメッセ
  • Year and Date: 2009-03-29
• [Presentation] リポ蛋白質受容体ファミリーLRP10はWnt/β-カテニン経路のシグナル伝達を抑制する (2009)
  • Author(s): 平田倫子、関家麻奈未、丁英姫, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-29
• [Presentation] Survey on desire to be slim, consciousness of body image and past dieting experience of university female students. (2008)
  • Author(s): T Fukumura, T Nishimoto, R Hasui, A Hosoda, Y Yamamoto
  • Organizer: 15^<th> International Congress of Dietetics
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-09-10
• [Presentation] メタボリックシンドローム発症時における肝臓体内時計関連遺伝子の発現解析 (2008)
  • Author(s): 佐伯茂, 金哲民, 岩本恭典, 関家麻奈未, 平田倫子, 山岸あづみ, 細田明美, 福村智恵, 金東浩
  • Organizer: 日本生理人類学会第58回大会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-06-08
• [Presentation] メタボリックシンドロームの脂質代謝に対する植物性タンパク質摂取の影響 (2008)
  • Author(s): 福村智恵, 進藤麻帆, 後藤絵理奈, 西元知美, 金東浩, 佐伯茂
  • Organizer: 第62回日本栄養・食糧学会大会
  • Place of Presentation: 女子栄養大学
  • Year and Date: 2008-05-04
• [Presentation] OLETFラットにおける体内時計遺伝子と脂質代謝関連遺伝子の発現解析 (2008)
  • Author(s): 金哲民, 岩本恭典, 関家麻奈未, 平田倫子,山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 第62回日本栄養・食糧学会大会
  • Place of Presentation: 女子栄養大学
  • Year and Date: 2008-05-04
• [Presentation] メタボリックシンドローム発症モデル動物における体内時計関連遺伝子の発現解析 (2008)
  • Author(s): 金哲民, 岩本恭典, 関家麻奈未, 平田倫子, 山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
  • Year and Date: 2008-03-28
• [Presentation] リポ蛋白質レセプターファミリーを介するシグナル伝達機構の解析 (2008)
  • Author(s): 関家麻奈未, 丁英姫, 平田倫子, 山岸あづみ, 細田明美, 福村智恵, 金東浩, 佐伯茂
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
  • Year and Date: 2008-03-28