Preventive effects of functional polyphenols on metabolic disease.

• Project/Area Number: 20700612
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Yonezawa women's junior college
• Principal Investigator: KURAKANE Shizue Yonezawa women's junior college, 健康栄養学科, 助手 (20442014)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: ポリフェノール / サルナシ / 糖尿病 / 肥満 / α-グルコシダーゼ / 吸収 / KK-Ayマウス / KK-A^yマウス / DNAマイクロアレイ

Research Abstract

Actinidia arguta polyphenols (AP) inhibitedα-glucosidase activity in vitro. The oral administration of AP with maltose and starch suppressed postprandial hyperglycemia involved the intake of the respective sugars by rats. A fraction contained isoquercitrin and hyperoside as major components of AP showed a stronger inhibitory activity for maltase. The improvement of glucose intolerance and increase in the CPT activity in the liver of KK-Ay mice fed with AP or isoquercitrin suggested that the suppression of gluconeogenesis and the enhancement ofβ-oxidation of lipids as well as the inhibition of maltase by AP and isoquercitrin might also be related to their anti-diabetic effects.

Research Products

• [Journal Article] Anti-diabetic effects of Actinidia arguta polyphenols on rats and KK-A^y mice. (2011)
  • Author(s): Shizue Kurakane, Noriko Yamada, Hideyo Sato, Kiharu Igarashi
  • Journal Title: Food Science and Technology Research Vol.17, No.2 Pages: 93-102
  • NAID: 10028188956
  • Peer Reviewed
• [Journal Article] Anti-diabetic effects of Actinidia arguta polyphenols on rats and KK-A^y mice (2011)
  • Author(s): Shizue Kurakane
  • Journal Title: Food Science and Technology Research Volume: Vol.17 Pages: 93-102
  • NAID: 10028188956
  • Peer Reviewed
• [Presentation] サルナシポリフェノール成分が2型糖尿病マウスに及ぼす影響 (2010)
  • Author(s): 倉兼静江、五十嵐喜治
  • Organizer: 第15回日本フードファクター学会
  • Place of Presentation: 宮城・仙台市民会館
  • Year and Date: 2010-10-04
• [Presentation] サルナシポリフェノール成分が2型糖尿病マウスに及ぼす影響 (2010)
  • Author(s): 倉兼静江
  • Organizer: 第15回日本フードファクター学会
  • Place of Presentation: 仙台市民会館(宮城県)
• [Presentation] サルナシの血圧上昇抑制作用 (2009)
  • Author(s): 倉兼静江、山田則子、五十嵐喜治
  • Organizer: 第43回日本栄養・食糧学会東北支部大会
  • Place of Presentation: 青森・青森県立保健大学
  • Year and Date: 2009-11-07
• [Presentation] サルナシの血圧上昇抑制作用 (2009)
  • Author(s): 倉兼静江
  • Organizer: 日本栄養・食糧学会東北支部大会
  • Place of Presentation: 青森県立保健大学(青森県)
  • Year and Date: 2009-11-07
• [Presentation] Effects of Actinidia Arguta Polyphenols on Alpha-Glucosidase Activity and Blood Glucose Levels in Mice (2009)
  • Author(s): Shizue kurakane, Noriko Yamada, Kiharu Igarashi
  • Organizer: 19^<th>International Congress of Nutrition
  • Place of Presentation: Thailand・Bangkok
  • Year and Date: 2009-10-06
• [Presentation] Effects of Actinidia Arguta Polyphenols on Alpha-Glucosidase Activity and Blood Glucose Levels in Mice (2009)
  • Author(s): 倉兼静江
  • Organizer: 19^<th> International Congress of Nutrition
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-10-06
• [Presentation] サルナシの血糖値上昇抑制作用 (2009)
  • Author(s): 倉兼静江、山田則子、五十嵐喜治
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡・マリンメッセ福岡
  • Year and Date: 2009-03-29
• [Presentation] サルナシの血糖値上昇抑制作用 (2009)
  • Author(s): 倉兼静江
  • Organizer: 日本農芸化学会
  • Place of Presentation: マリンメッセ福岡(福岡県)
  • Year and Date: 2009-03-29