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Functional analysis of novel genes related to the mechanism of radiation-induced mammary carcinogenesis

Research Project

Project/Area Number 20710049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

IMAOKA Tatsuhiko  National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員 (40356134)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords放射線発がん / 乳がん / 遺伝子機能解析 / siRNA / RNA干渉 / がん細胞株 / siRNA/RNA干渉
Research Abstract

This study suggests that the NRARP gene, which is overexpressed in radiation-induced rat mammary carcinoma, plays a crucial role in proliferation of human breast cancer cells, probably via regulation of the cell cycle. Since NRARP is important in intracellular signaling and regulation of developmental processes, it may be also relevant in the mechanism of radiation-induced mammary carcinogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (96 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 12 results) Presentation (76 results) Remarks (3 results)

  • [Journal Article] Pre-and Postpubertal Irradiation Induces Mammary Cancers with Distinct Expression of Hormone Receptors, ErbB Ligands and Developmental Genes in Rats.2011

    • Author(s)
      Tatsuhiko Imaoka, Mayumi Nishimura, Daisuke Iizuka, Yukiko Nishimura, Yasushi Ohmachi, Yoshiya Shimada
    • Journal Title

      Molecular Carcinogenesis 50(7)

      Pages: 539-552

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre- and Postpubertal Irradiation Induces Mammary Cancers with Distinct Expression of Hormone Receptors, ErbB Ligands and Developmental Genes in Rats2011

    • Author(s)
      Tatsuhiko Imaoka, et al.
    • Journal Title

      Molecular Carcinogenesis

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions of low dose radiation with other factors in carcinogenesis in vivo2011

    • Author(s)
      Yoshiya Shimada, et al.
    • Journal Title

      Health, Physics

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas.2010

    • Author(s)
      Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Yukiko Nishimura, Yoshiya Shimada
    • Journal Title

      Radiation Research 174(2)

      Pages: 206-215

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the biology of heavy-ion cancer therapy.2010

    • Author(s)
      Nobuyuki Hamada, Tatsuhiko Imaoka, Shinichiro Masunaga, Toshiyuki Ogata, Ryuichi Okayasu, Akihisa Takahashi, Takamitsu Kato, Yasuhiko Kobayashi, Takeo Ohnishi, Koji Ono, Yoshiya Shimada, Teruki Teshima
    • Journal Title

      Journal of Radiation Research 51(4)

      Pages: 365-383

    • NAID

      10026563608

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the biology of heavy-ion cancer therapy2010

    • Author(s)
      Nobuyuki Hamada, et al.
    • Journal Title

      Journal of Radiation Research

      Volume: 51 Pages: 365-383

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique characteristics of radiation-induced apoptosis in the postnatally developing small intestine and colon2010

    • Author(s)
      Tomoko Miyoshi-Imamura, et al.
    • Journal Title

      Radiation Research 173

      Pages: 310-318

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas2010

    • Author(s)
      Yu Yamaguchi, et al.
    • Journal Title

      Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research 686

      Pages: 30-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas2010

    • Author(s)
      Daisuke Iizuka, et al.
    • Journal Title

      Radiation Research (未定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-Induced Mammary Carcinogenesis in Rodent Models : What's Different from Chemical Carcinogenesis?2009

    • Author(s)
      Tatsuhiko Imaoka, Mayumi Nishimura, Daisuke Iizuka, Kazuhiro Daino, Takashi Takabatake, Mieko Okamoto, Shizuko Kakinuma, Yoshiya Shimada
    • Journal Title

      Journal of Radiation Research 50(4)

      Pages: 281-293

    • NAID

      10025911934

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced mammary carcinogenesis in rodent models : what's different from chemical carcinogenesis?2009

    • Author(s)
      Tatsuhiko Imaoka, et al.
    • Journal Title

      Journal of Radiation Research 50

      Pages: 281-293

    • NAID

      10025911934

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 医療被曝と発がんリスク2009

    • Author(s)
      島田義也, 他
    • Journal Title

      公衆衛生 73

      Pages: 922-926

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 胸部の低線量放射線被ばくの安全性について考える2009

    • Author(s)
      島田義也, 他
    • Journal Title

      CT検診 16

      Pages: 165-170

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 重粒子線のラット乳がん誘発作用2009

    • Author(s)
      今岡 達彦、他
    • Journal Title

      放射線生物研究 44(印刷中)

    • NAID

      130006999714

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Radiation Health Risk Sciences(シュプリンガージャパン)2009

    • Author(s)
      Masahiro Nakashima, et al.
    • Pages
      227-231
    • Related Report
      2008 Annual Research Report
  • [Journal Article] Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas2008

    • Author(s)
      Tatsuhiko Imaoka, et al.
    • Journal Title

      Journal of Radiation Research 49

      Pages: 349-360

    • NAID

      110006820174

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発癌剤の複合曝露によって誘発されるラット乳癌の発現マイクロアレイ解析2008

    • Author(s)
      今岡 達彦、他
    • Journal Title

      乳癌基礎研究 17

      Pages: 31-36

    • Related Report
      2008 Annual Research Report
  • [Presentation] デキストラン硫酸誘発マウス潰瘍性大腸炎の再生過程における組織病理及び分子病理学的解析2011

    • Author(s)
      森岡孝満, 他
    • Organizer
      文部科学省科学研究費新学術領域「がん研究等の特性を踏まえた支援活動」平成22年度「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Radiation exposure at early stage of life2010

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      NIRS-Workshop as an IAEA Collaborating Centre
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas2010

    • Author(s)
      Daisuke Iizuka, et al.
    • Organizer
      The 20th International Symposium of Hiroshima Cancer Seminar in conjunction with Three Universities' Consortium
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2010-10-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発生関連因子Notch-regulated ankyrin repeat protein(NRARP)のヒト乳がん細胞株における機能解析2010

    • Author(s)
      奥谷倫未、今岡達彦、臺野和広、飯塚大輔、西村まゆみ、野川宏幸、島田義也
    • Organizer
      第33回日本分子生物学会・第83回日本生化学学会合同
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット放射線誘発乳がんに特徴的なマイクロRNAが乳がん細胞株に与える影響2010

    • Author(s)
      飯塚大輔、今岡達彦、西村まゆみ、河合秀彦、鈴木文男、島田義也
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都市
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas2010

    • Author(s)
      Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Yukiko Nishimura, Yoshiya Shimada
    • Organizer
      The 20th International Symposium of Hiroshima Cancer Seminar in conjunction with Three Universities' Consortium,
    • Place of Presentation
      Hiroshima
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット乳腺において放射線発がん標的になりうる長寿命細胞の増殖性およびその制御2010

    • Author(s)
      今岡達彦、坂西良彌、久恒裕美、西村由希子、西村まゆみ、島田義也
    • Organizer
      京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線誘発乳癌におけるmTOR経路の解析2010

    • Author(s)
      高畠賢、臺野和広、今岡達彦、福士政広、島田義也
    • Organizer
      京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats2010

    • Author(s)
      Mayumi Nishimura, Tatsuhiko Imaoka, Takashi Takabatake, Kazuhiro Daino, Shizuko Kakinuma, Tomomi Okutani, Masaru Takabatake, Yoshiya Shimada
    • Organizer
      21st Meeting of the European Association for Cancer Research
    • Place of Presentation
      オスロ
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered Expression of MicroRNAs in Radiation-induced Rat Mammary Carcinoma.2010

    • Author(s)
      Daisuke Iizuka, Tatsuhiko Imaoka, Mayumi Nishimura, Hidehiko Kawai, Fumio Suzuki, Yoshiya Shimada
    • Organizer
      Gordon Research Conference-Mammary Gland Biology
    • Place of Presentation
      Lucca
    • Related Report
      2010 Final Research Report
  • [Presentation] Pre- and Postpubertal Exposure to Ionizing Radiation Induces Mammary Cancers with Distinct Expression of ErbB Ligand Genes and Hormone Receptors in Rats2010

    • Author(s)
      Tatsuhiko Imaoka, Mayumi Nishimura, Yukiko Nishimura, Yasushi Ohmachi, Daisuke Iizuka, Kazuhiro Daino, Yoshiya Shimada
    • Organizer
      Gordon Research Conference for Mammary Gland Biology
    • Place of Presentation
      Lucca
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening of candidate genes regulated by DNA methylation during mammary acinar morphogenesis in vitro2010

    • Author(s)
      Kazuhiro Daino, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
    • Organizer
      Gordon Research Conferences for Mammary Gland Biology
    • Place of Presentation
      Lucca
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional Analysis of Novel Mammary Cancer-Related Genes, Keystone Symposia Integration of Developmental Signaling Pathways2010

    • Author(s)
      Tomomi Okutani, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Hiroyuki Nogawa, Yoshiya Shimada
    • Organizer
      Victoria
    • Place of Presentation
      British Columbia
    • Related Report
      2010 Final Research Report
  • [Presentation] 発生関連因子Notch-regulated ankyrin repeat protein (NRARP)のヒト乳がん細胞株における機能解析2010

    • Author(s)
      奥谷倫未, 他
    • Organizer
      第33回日本分子生物学会・第83回日本生化学学会合同大会
    • Place of Presentation
      神戸市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pre- and Postpubertal Exposure to Ionizing Radiation Induces Mammary Cancers with Distinct Expression of ErbB Ligand Genes and Hormone Receptors in Rats2010

    • Author(s)
      Tatsuhiko Imaoka, et al.
    • Organizer
      Gordon Research Conference-Mammary Gland Biology
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット乳腺において放射線発がん標的になりうる長寿命細胞の増殖性およびその制御2010

    • Author(s)
      今岡達彦, 他
    • Organizer
      平成22年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Altered Expression of MicroRNAs in Radiation-induced Rat Mammary Carcinoma.2010

    • Author(s)
      Daisuke Iizuka, et al.
    • Organizer
      Gordon Research Conference-Mammary Gland Biology
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微小環境による乳がん表現型の正常化においてエピジェネティックに制御される遺伝子の探索2010

    • Author(s)
      臺野和広, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微小環境による乳がん表現型の正常化とその分子機構の解明2010

    • Author(s)
      臺野和広, 他
    • Organizer
      平成22年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微小環境による乳がん表現型の正常化とその分子機構の解明2010

    • Author(s)
      臺野和広, 他
    • Organizer
      文部科学省平成22年度がん若手研究者ワークショップ
    • Place of Presentation
      長野県茅野市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線誘発乳癌におけるmTOR経路の解析2010

    • Author(s)
      高畠賢, 他
    • Organizer
      平成22年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Screening of candidate genes regulated by DNA methylation during mammary acinar morphogenesis in vitro2010

    • Author(s)
      Kazuhiro Daino, et al.
    • Organizer
      Gordon Research Conference-Mammary Gland Biology
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats2010

    • Author(s)
      Mayumi Nishimura, et al.
    • Organizer
      21st Meeting of the European Association for Cancer Research
    • Place of Presentation
      Oslo, Norway
    • Related Report
      2010 Annual Research Report
  • [Presentation] Number of stem-like cells and the genetic susceptibility to mammary carcinogenesis in rats2010

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      21st Meeting of the European Association for Cancer Research
    • Place of Presentation
      Oslo, Norway
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放医研における動物実験のアーカイブ化の進展2010

    • Author(s)
      島田義也, 他
    • Organizer
      日本放射線影響学会大53回大会
    • Place of Presentation
      京都市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Experimental research on radiation health effects on children2010

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      Bond symposium : Biological consequences and health risks of low level exposure to ionizing radiation
    • Place of Presentation
      Richland, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional Analysis of Novel Mammary Cancer-Related Genes2010

    • Author(s)
      Tomomi Okutani, et al.
    • Organizer
      Keystone Symposia - Integration of Developmental Signaling Pathways
    • Place of Presentation
      カナダ、ビクトリア市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低線量放射線研究の現状2009

    • Author(s)
      島田義也, 他
    • Organizer
      日本CT検診学会セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of age at the time of radiation exposure on rodent mammary tumorigenesis2009

    • Author(s)
      Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Daisuke Iizuka, Mieko Okamoto, Yukiko Nishimura, Tomomi Okutani, Yoshiya Shimada
    • Organizer
      KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      Chiba
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered expression of microRNAs in radiation-induced rat mammary carcinoma2009

    • Author(s)
      Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Hidehiko Kawai, Fumio Suzuki, Yoshiya Shimada
    • Organizer
      KIDS workshop 2009 in NIRS-IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      Chiba
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA copy number changes in radiation-induced mammary carcinomas in (SDxCOP) F1 rats2009

    • Author(s)
      Mayumi Nishimura, Tatsuhiko Imaoka, Takashi Takabatake, Yoshiya Shimada
    • Organizer
      KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      Chiba
    • Related Report
      2010 Final Research Report
  • [Presentation] Epigenetic gene regulation during mammary gland morphogenesis2009

    • Author(s)
      Kazuhiro Daino, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
    • Organizer
      KIDS workshop 2009 in NIRS-IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      Chiba
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規乳がん関連遺伝子のヒト乳がん細胞株における機能解析2009

    • Author(s)
      奥谷倫未、今岡達彦、飯塚大輔、野川宏幸、島田義也
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA発現の網羅的解析2009

    • Author(s)
      飯塚大輔、今岡達彦、西村まゆみ、高畠貴志、柿沼志津子、河合秀彦、鈴木文男、島田義也
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるLOHとDNAコピー数の解析2009

    • Author(s)
      西村まゆみ、今岡達彦、高畠貴志、飯塚大輔、臺野和広、柿沼志津子、島田義也
    • Organizer
      放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線発がんの被ばく時年齢依存性:実験動物乳がんモデルを中心に2009

    • Author(s)
      今岡達彦、西村まゆみ、飯塚大輔、臺野和広、西村由希子、奥谷倫未、柿沼志津子、島田義也
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規乳がん関連遺伝子のヒト乳がん細胞株における機能解析2009

    • Author(s)
      奥谷倫未、今岡達彦、飯塚大輔、野川宏幸、島田義也
    • Organizer
      平成21年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 放射線誘発ラット乳がんにおけるmicroRNA解析2009

    • Author(s)
      飯塚大輔、今岡達彦、西村まゆみ、高畠貴志、柿沼志津子、河合秀彦、鈴木文男、島田義也
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Influence of co-exposure to gamma-rays on the manifestation of MNU- or PhIP-induced mutations in rat mammary carcinomas,2009

    • Author(s)
      Mayumi Nishimura, Tatsuhiko Imaoka, Kazuhiro Daino, Shizuko Kakinuma , Yoshiya Shimada
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      Seoul
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of age at the time of radiation exposure on rodent mammary tumorigenesis.2009

    • Author(s)
      Tatsuhiko Imaoka, et al.
    • Organizer
      IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Securing and fostering of younger experts responsible for radiation protection : Views from young academic researchers2009

    • Author(s)
      Tatsuhiko Imaoka
    • Organizer
      5th Asian Regional Conference on the Evolution of the System of Radiation Protection
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mlh1欠損マウスに発生する消化管腫瘍とTリンパ腫の被ばく時年齢依存性2009

    • Author(s)
      柿沼志津子, 他
    • Organizer
      第24回発癌病理研究会
    • Place of Presentation
      七尾市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線発がんの被ばく時年齢依存性:実験動物乳がんモデルを中心に2009

    • Author(s)
      今岡達彦, 他
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mlh1欠損マウスに発生する腸管腫瘍の被ばく時年齢依存性2009

    • Author(s)
      柿沼志津子, 他
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「放射線防護」と若手研究者~アンケート調査から~2009

    • Author(s)
      今岡達彦, 他
    • Organizer
      京都大学原子炉専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetic gene regulation during mammary gland morphogenesis2009

    • Author(s)
      Kazuhiro Daino, et al.
    • Organizer
      IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Detailed analysis of Ikaros mutation in mouse thymic lymphoma induced by simultaneous exposure of X-rays and N-ethyl-N-nitrosourea2009

    • Author(s)
      Yoshiko Amasaki, et al.
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      韓国、漢城市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of Ikaros, p53 and Kras point mutation in mouse thymiclymphomas induced by simultaneous exposure to X-ray and N-ethvl-N-nitrosourea2009

    • Author(s)
      Shinobu Hirano, et al.
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      韓国、漢城市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Influence of co-exposure to gamma-rays on the manifestation of MNU- or PhiIP-induced mutations in rat mammary carcinomas2009

    • Author(s)
      Mayumi Nishimura, et al.
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      韓国、漢城市
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるLOHとDNAコピー数の解析2009

    • Author(s)
      西村まゆみ, 他
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Detailed analysis of Ikaros mutations in mouse thymic lymphoma induced by simultaneous exposure to X-rays and N-ethyl-N-nitrosourea2009

    • Author(s)
      Yoshiko Amasaki, et al.
    • Organizer
      IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA発現の網羅的解析2009

    • Author(s)
      飯塚大輔, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] DNA copy number changes in radiation-induced mammary carcinomas in (SDxCOP)F1 rats2009

    • Author(s)
      Mayumi Nishimura, et al.
    • Organizer
      IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Altered expression of microRNAs in radiation-induced rat mammary carcinoma2009

    • Author(s)
      Daisuke Iizuka, et al.
    • Organizer
      IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
    • Place of Presentation
      千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic changes in heavyion-induced T-cell lymphomas in B6C3F1 mice2009

    • Author(s)
      Erika Takahashi, et al.
    • Organizer
      第23回日本宇宙生物科学会
    • Place of Presentation
      つくば市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Experimental research on radiation health effects on children2009

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      Third Conference on Children's Environmental Health, World Health Organization
    • Place of Presentation
      韓国、釜山市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化学発がんに及ぼす低線量放射線の影響について2009

    • Author(s)
      島田義也, 他
    • Organizer
      量子ビーム応用研究開発部門研究交流会
    • Place of Presentation
      茨城県東海村
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎児・小児の放射線リスク2009

    • Author(s)
      島田義也, 他
    • Organizer
      日本放射線技術学会第65回大会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular signature in radiation-induced T-cell lymphomas2009

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      韓国、漢城市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modification of threshold dose in radiation-induced mouse lymphoma development2008

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      International Symposium on Genotoxic and Carcinogenic Thresholds
    • Place of Presentation
      東京
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 重粒子線のラット乳がん誘発作用2008

    • Author(s)
      今岡達彦、西村まゆみ、飯塚大輔、柿沼志津子、島田義也
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 電離放射線およびメチルニトロソ尿素によるラット乳がん誘発作用の年齢依存性およびそのメカニズム2008

    • Author(s)
      今岡達彦、西村まゆみ、島田義也
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 電離放射線およびメチルニトロソ尿素によるラット乳がん誘発作用の年齢依存性およびそのメカニズム2008

    • Author(s)
      今岡達彦、西村まゆみ、波多野由希子、飯塚大輔、柿沼志津子、島田義也
    • Organizer
      平成20年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 放射線誘発ラット乳がんにおけるゲノムコピー数異常の網羅的解析2008

    • Author(s)
      飯塚大輔、今岡達彦、高畠貴志、西村まゆみ、柿沼志津子、波多野由希子、島田義也
    • Organizer
      平成20年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪府泉南郡
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 重粒子線のラット乳がん誘発作用2008

    • Author(s)
      今岡達彦、他
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Possible fingerprints of radiation-induced mammary cancers in rats2008

    • Author(s)
      Tatsuhiko Imaoka
    • Organizer
      Workshop on "Radiation Risk of Breast Cancer : what can/should we do in the future? "
    • Place of Presentation
      広島市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression and promoter methylation of Sic family genes in rat mammary carcinomas induced by different etiologies2008

    • Author(s)
      Mayumi Nishimura, et al.
    • Organizer
      The 26th Congress of the International Association for Breast Cancer Research
    • Place of Presentation
      倉敷市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Minマウスにおける放射線発がん機構の解析2008

    • Author(s)
      岡本美恵子、他
    • Organizer
      第23回発癌病理研究会
    • Place of Presentation
      鳥羽市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放射線と化学物質の複合曝露によるマウス胸腺リンパ腫の発生とIkarosの変異解析2008

    • Author(s)
      柿沼志津子、他
    • Organizer
      京都T細胞会議第18回学術研究集会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 宇宙放射線によるマウスの寿命短縮効果2008

    • Author(s)
      柿沼志津子、他
    • Organizer
      日本宇宙生物科学会第22回大会
    • Place of Presentation
      橿原市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低線量放射線はエチルニトロソウレアによるT細胞白血病発生を抑制する2008

    • Author(s)
      柿沼志津子、他
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ミスマッチ修復欠損マウスにおける放射線発がんの特徴2008

    • Author(s)
      島田義也、他
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスTリンパ腫におけるIkarosならびにp53変異の系統差2008

    • Author(s)
      高橋江里佳、他
    • Organizer
      日本宇宙生物科学会第22回大会
    • Place of Presentation
      橿原市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放射線と化学物質の同時複合曝露によるマウス胸腺リンパ腫発生における被ばく時年齢の影響2008

    • Author(s)
      甘崎佳子、他
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放射線と化学物質の複合曝露によって誘発されたマウス胸腺リンパ腫におけるKrasとIkarosの突然変異2008

    • Author(s)
      古渡礼恵、他
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Radiation accelerated carcinogenesis in M1h1 knockout mice2008

    • Author(s)
      Yoshiya Shimada, et al.
    • Organizer
      International Symposium on Carcinogenesis and Genetic Effects of Low Dose Radiation Exposure
    • Place of Presentation
      青森県上北郡
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.nirs.go.jp/db/seikadb/Welcome.php

    • Related Report
      2010 Annual Research Report
  • [Remarks] 発表論文等データベース

    • URL

      http://www.nirs.go.jp/db/seikadb/Welcome.php

    • Related Report
      2009 Annual Research Report
  • [Remarks] 発表論文等データベース

    • URL

      http://www.nirs.go.jp/db/seikadb/Welcome.php

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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