Functional analysis of novel genes related to the mechanism of radiation-induced mammary carcinogenesis

• Project/Area Number: 20710049
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: IMAOKA Tatsuhiko National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員 (40356134)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 放射線発がん / 乳がん / 遺伝子機能解析 / siRNA / RNA干渉 / がん細胞株 / siRNA/RNA干渉

Research Abstract

This study suggests that the NRARP gene, which is overexpressed in radiation-induced rat mammary carcinoma, plays a crucial role in proliferation of human breast cancer cells, probably via regulation of the cell cycle. Since NRARP is important in intracellular signaling and regulation of developmental processes, it may be also relevant in the mechanism of radiation-induced mammary carcinogenesis.

Research Products

• [Journal Article] Pre-and Postpubertal Irradiation Induces Mammary Cancers with Distinct Expression of Hormone Receptors, ErbB Ligands and Developmental Genes in Rats. (2011)
  • Author(s): Tatsuhiko Imaoka, Mayumi Nishimura, Daisuke Iizuka, Yukiko Nishimura, Yasushi Ohmachi, Yoshiya Shimada
  • Journal Title: Molecular Carcinogenesis 50(7) Pages: 539-552
  • Peer Reviewed
• [Journal Article] Pre- and Postpubertal Irradiation Induces Mammary Cancers with Distinct Expression of Hormone Receptors, ErbB Ligands and Developmental Genes in Rats (2011)
  • Author(s): Tatsuhiko Imaoka, et al.
  • Journal Title: Molecular Carcinogenesis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Interactions of low dose radiation with other factors in carcinogenesis in vivo (2011)
  • Author(s): Yoshiya Shimada, et al.
  • Journal Title: Health, Physics Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas. (2010)
  • Author(s): Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Yukiko Nishimura, Yoshiya Shimada
  • Journal Title: Radiation Research 174(2) Pages: 206-215
  • Peer Reviewed
• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy. (2010)
  • Author(s): Nobuyuki Hamada, Tatsuhiko Imaoka, Shinichiro Masunaga, Toshiyuki Ogata, Ryuichi Okayasu, Akihisa Takahashi, Takamitsu Kato, Yasuhiko Kobayashi, Takeo Ohnishi, Koji Ono, Yoshiya Shimada, Teruki Teshima
  • Journal Title: Journal of Radiation Research 51(4) Pages: 365-383
  • NAID: 10026563608
  • Peer Reviewed
• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy (2010)
  • Author(s): Nobuyuki Hamada, et al.
  • Journal Title: Journal of Radiation Research Volume: 51 Pages: 365-383
  • Peer Reviewed
• [Journal Article] Unique characteristics of radiation-induced apoptosis in the postnatally developing small intestine and colon (2010)
  • Author(s): Tomoko Miyoshi-Imamura, et al.
  • Journal Title: Radiation Research 173 Pages: 310-318
  • Peer Reviewed
• [Journal Article] Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas (2010)
  • Author(s): Yu Yamaguchi, et al.
  • Journal Title: Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research 686 Pages: 30-38
  • Peer Reviewed
• [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas (2010)
  • Author(s): Daisuke Iizuka, et al.
  • Journal Title: Radiation Research (未定)
  • Peer Reviewed
• [Journal Article] Radiation-Induced Mammary Carcinogenesis in Rodent Models : What's Different from Chemical Carcinogenesis? (2009)
  • Author(s): Tatsuhiko Imaoka, Mayumi Nishimura, Daisuke Iizuka, Kazuhiro Daino, Takashi Takabatake, Mieko Okamoto, Shizuko Kakinuma, Yoshiya Shimada
  • Journal Title: Journal of Radiation Research 50(4) Pages: 281-293
  • NAID: 10025911934
  • Peer Reviewed
• [Journal Article] Radiation-induced mammary carcinogenesis in rodent models : what's different from chemical carcinogenesis? (2009)
  • Author(s): Tatsuhiko Imaoka, et al.
  • Journal Title: Journal of Radiation Research 50 Pages: 281-293
  • NAID: 10025911934
  • Peer Reviewed
• [Journal Article] 医療被曝と発がんリスク (2009)
  • Author(s): 島田義也, 他
  • Journal Title: 公衆衛生 73 Pages: 922-926
• [Journal Article] 胸部の低線量放射線被ばくの安全性について考える (2009)
  • Author(s): 島田義也, 他
  • Journal Title: CT検診 16 Pages: 165-170
• [Journal Article] 重粒子線のラット乳がん誘発作用 (2009)
  • Author(s): 今岡 達彦、他
  • Journal Title: 放射線生物研究 44(印刷中)
  • NAID: 130006999714
• [Journal Article] Radiation Health Risk Sciences(シュプリンガージャパン) (2009)
  • Author(s): Masahiro Nakashima, et al.
  • Pages: 227-231
• [Journal Article] Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas (2008)
  • Author(s): Tatsuhiko Imaoka, et al.
  • Journal Title: Journal of Radiation Research 49 Pages: 349-360
  • NAID: 110006820174
  • Peer Reviewed
• [Journal Article] 発癌剤の複合曝露によって誘発されるラット乳癌の発現マイクロアレイ解析 (2008)
  • Author(s): 今岡 達彦、他
  • Journal Title: 乳癌基礎研究 17 Pages: 31-36
• [Presentation] デキストラン硫酸誘発マウス潰瘍性大腸炎の再生過程における組織病理及び分子病理学的解析 (2011)
  • Author(s): 森岡孝満, 他
  • Organizer: 文部科学省科学研究費新学術領域「がん研究等の特性を踏まえた支援活動」平成22年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 滋賀県大津市
• [Presentation] Radiation exposure at early stage of life (2010)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: NIRS-Workshop as an IAEA Collaborating Centre
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2010-11-12
• [Presentation] DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas (2010)
  • Author(s): Daisuke Iizuka, et al.
  • Organizer: The 20th International Symposium of Hiroshima Cancer Seminar in conjunction with Three Universities' Consortium
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2010-10-31
• [Presentation] 発生関連因子Notch-regulated ankyrin repeat protein(NRARP)のヒト乳がん細胞株における機能解析 (2010)
  • Author(s): 奥谷倫未、今岡達彦、臺野和広、飯塚大輔、西村まゆみ、野川宏幸、島田義也
  • Organizer: 第33回日本分子生物学会・第83回日本生化学学会合同
  • Place of Presentation: 兵庫県神戸市
• [Presentation] ラット放射線誘発乳がんに特徴的なマイクロRNAが乳がん細胞株に与える影響 (2010)
  • Author(s): 飯塚大輔、今岡達彦、西村まゆみ、河合秀彦、鈴木文男、島田義也
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: 京都市
• [Presentation] DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas (2010)
  • Author(s): Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Yukiko Nishimura, Yoshiya Shimada
  • Organizer: The 20th International Symposium of Hiroshima Cancer Seminar in conjunction with Three Universities' Consortium,
  • Place of Presentation: Hiroshima
• [Presentation] ラット乳腺において放射線発がん標的になりうる長寿命細胞の増殖性およびその制御 (2010)
  • Author(s): 今岡達彦、坂西良彌、久恒裕美、西村由希子、西村まゆみ、島田義也
  • Organizer: 京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] 放射線誘発乳癌におけるmTOR経路の解析 (2010)
  • Author(s): 高畠賢、臺野和広、今岡達彦、福士政広、島田義也
  • Organizer: 京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats (2010)
  • Author(s): Mayumi Nishimura, Tatsuhiko Imaoka, Takashi Takabatake, Kazuhiro Daino, Shizuko Kakinuma, Tomomi Okutani, Masaru Takabatake, Yoshiya Shimada
  • Organizer: 21st Meeting of the European Association for Cancer Research
  • Place of Presentation: オスロ
• [Presentation] Altered Expression of MicroRNAs in Radiation-induced Rat Mammary Carcinoma. (2010)
  • Author(s): Daisuke Iizuka, Tatsuhiko Imaoka, Mayumi Nishimura, Hidehiko Kawai, Fumio Suzuki, Yoshiya Shimada
  • Organizer: Gordon Research Conference-Mammary Gland Biology
  • Place of Presentation: Lucca
• [Presentation] Pre- and Postpubertal Exposure to Ionizing Radiation Induces Mammary Cancers with Distinct Expression of ErbB Ligand Genes and Hormone Receptors in Rats (2010)
  • Author(s): Tatsuhiko Imaoka, Mayumi Nishimura, Yukiko Nishimura, Yasushi Ohmachi, Daisuke Iizuka, Kazuhiro Daino, Yoshiya Shimada
  • Organizer: Gordon Research Conference for Mammary Gland Biology
  • Place of Presentation: Lucca
• [Presentation] Screening of candidate genes regulated by DNA methylation during mammary acinar morphogenesis in vitro (2010)
  • Author(s): Kazuhiro Daino, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
  • Organizer: Gordon Research Conferences for Mammary Gland Biology
  • Place of Presentation: Lucca
• [Presentation] Functional Analysis of Novel Mammary Cancer-Related Genes, Keystone Symposia Integration of Developmental Signaling Pathways (2010)
  • Author(s): Tomomi Okutani, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Hiroyuki Nogawa, Yoshiya Shimada
  • Organizer: Victoria
  • Place of Presentation: British Columbia
• [Presentation] 発生関連因子Notch-regulated ankyrin repeat protein (NRARP)のヒト乳がん細胞株における機能解析 (2010)
  • Author(s): 奥谷倫未, 他
  • Organizer: 第33回日本分子生物学会・第83回日本生化学学会合同大会
  • Place of Presentation: 神戸市
• [Presentation] Pre- and Postpubertal Exposure to Ionizing Radiation Induces Mammary Cancers with Distinct Expression of ErbB Ligand Genes and Hormone Receptors in Rats (2010)
  • Author(s): Tatsuhiko Imaoka, et al.
  • Organizer: Gordon Research Conference-Mammary Gland Biology
  • Place of Presentation: Lucca, Italy
• [Presentation] ラット乳腺において放射線発がん標的になりうる長寿命細胞の増殖性およびその制御 (2010)
  • Author(s): 今岡達彦, 他
  • Organizer: 平成22年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] Altered Expression of MicroRNAs in Radiation-induced Rat Mammary Carcinoma. (2010)
  • Author(s): Daisuke Iizuka, et al.
  • Organizer: Gordon Research Conference-Mammary Gland Biology
  • Place of Presentation: Lucca, Italy
• [Presentation] 微小環境による乳がん表現型の正常化においてエピジェネティックに制御される遺伝子の探索 (2010)
  • Author(s): 臺野和広, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
• [Presentation] 微小環境による乳がん表現型の正常化とその分子機構の解明 (2010)
  • Author(s): 臺野和広, 他
  • Organizer: 平成22年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] 微小環境による乳がん表現型の正常化とその分子機構の解明 (2010)
  • Author(s): 臺野和広, 他
  • Organizer: 文部科学省平成22年度がん若手研究者ワークショップ
  • Place of Presentation: 長野県茅野市
• [Presentation] 放射線誘発乳癌におけるmTOR経路の解析 (2010)
  • Author(s): 高畠賢, 他
  • Organizer: 平成22年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] Screening of candidate genes regulated by DNA methylation during mammary acinar morphogenesis in vitro (2010)
  • Author(s): Kazuhiro Daino, et al.
  • Organizer: Gordon Research Conference-Mammary Gland Biology
  • Place of Presentation: Lucca, Italy
• [Presentation] DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats (2010)
  • Author(s): Mayumi Nishimura, et al.
  • Organizer: 21st Meeting of the European Association for Cancer Research
  • Place of Presentation: Oslo, Norway
• [Presentation] Number of stem-like cells and the genetic susceptibility to mammary carcinogenesis in rats (2010)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: 21st Meeting of the European Association for Cancer Research
  • Place of Presentation: Oslo, Norway
• [Presentation] 放医研における動物実験のアーカイブ化の進展 (2010)
  • Author(s): 島田義也, 他
  • Organizer: 日本放射線影響学会大53回大会
  • Place of Presentation: 京都市
• [Presentation] Experimental research on radiation health effects on children (2010)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: Bond symposium : Biological consequences and health risks of low level exposure to ionizing radiation
  • Place of Presentation: Richland, USA
• [Presentation] Functional Analysis of Novel Mammary Cancer-Related Genes (2010)
  • Author(s): Tomomi Okutani, et al.
  • Organizer: Keystone Symposia - Integration of Developmental Signaling Pathways
  • Place of Presentation: カナダ、ビクトリア市
• [Presentation] 低線量放射線研究の現状 (2009)
  • Author(s): 島田義也, 他
  • Organizer: 日本CT検診学会セミナー
  • Place of Presentation: 東京
  • Year and Date: 2009-06-20
• [Presentation] Effect of age at the time of radiation exposure on rodent mammary tumorigenesis (2009)
  • Author(s): Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Daisuke Iizuka, Mieko Okamoto, Yukiko Nishimura, Tomomi Okutani, Yoshiya Shimada
  • Organizer: KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: Chiba
• [Presentation] Altered expression of microRNAs in radiation-induced rat mammary carcinoma (2009)
  • Author(s): Daisuke Iizuka, Tatsuhiko Imaoka, Takashi Takabatake, Mayumi Nishimura, Shizuko Kakinuma, Hidehiko Kawai, Fumio Suzuki, Yoshiya Shimada
  • Organizer: KIDS workshop 2009 in NIRS-IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: Chiba
• [Presentation] DNA copy number changes in radiation-induced mammary carcinomas in (SDxCOP) F1 rats (2009)
  • Author(s): Mayumi Nishimura, Tatsuhiko Imaoka, Takashi Takabatake, Yoshiya Shimada
  • Organizer: KIDS workshop 2009 in NIRS - IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: Chiba
• [Presentation] Epigenetic gene regulation during mammary gland morphogenesis (2009)
  • Author(s): Kazuhiro Daino, Tatsuhiko Imaoka, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
  • Organizer: KIDS workshop 2009 in NIRS-IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: Chiba
• [Presentation] 新規乳がん関連遺伝子のヒト乳がん細胞株における機能解析 (2009)
  • Author(s): 奥谷倫未、今岡達彦、飯塚大輔、野川宏幸、島田義也
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
• [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA発現の網羅的解析 (2009)
  • Author(s): 飯塚大輔、今岡達彦、西村まゆみ、高畠貴志、柿沼志津子、河合秀彦、鈴木文男、島田義也
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] ラット放射線誘発乳がんにおけるLOHとDNAコピー数の解析 (2009)
  • Author(s): 西村まゆみ、今岡達彦、高畠貴志、飯塚大輔、臺野和広、柿沼志津子、島田義也
  • Organizer: 放射線影響学会第52回大会
  • Place of Presentation: 広島市
• [Presentation] 放射線発がんの被ばく時年齢依存性:実験動物乳がんモデルを中心に (2009)
  • Author(s): 今岡達彦、西村まゆみ、飯塚大輔、臺野和広、西村由希子、奥谷倫未、柿沼志津子、島田義也
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
• [Presentation] 新規乳がん関連遺伝子のヒト乳がん細胞株における機能解析 (2009)
  • Author(s): 奥谷倫未、今岡達彦、飯塚大輔、野川宏幸、島田義也
  • Organizer: 平成21年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] 放射線誘発ラット乳がんにおけるmicroRNA解析 (2009)
  • Author(s): 飯塚大輔、今岡達彦、西村まゆみ、高畠貴志、柿沼志津子、河合秀彦、鈴木文男、島田義也
  • Organizer: 第148回日本獣医学会
  • Place of Presentation: 鳥取市
• [Presentation] Influence of co-exposure to gamma-rays on the manifestation of MNU- or PhIP-induced mutations in rat mammary carcinomas, (2009)
  • Author(s): Mayumi Nishimura, Tatsuhiko Imaoka, Kazuhiro Daino, Shizuko Kakinuma , Yoshiya Shimada
  • Organizer: 2nd Asian Congress of Radiation Research
  • Place of Presentation: Seoul
• [Presentation] Effect of age at the time of radiation exposure on rodent mammary tumorigenesis. (2009)
  • Author(s): Tatsuhiko Imaoka, et al.
  • Organizer: IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: 千葉市
• [Presentation] Securing and fostering of younger experts responsible for radiation protection : Views from young academic researchers (2009)
  • Author(s): Tatsuhiko Imaoka
  • Organizer: 5th Asian Regional Conference on the Evolution of the System of Radiation Protection
  • Place of Presentation: 千葉市
• [Presentation] Mlh1欠損マウスに発生する消化管腫瘍とTリンパ腫の被ばく時年齢依存性 (2009)
  • Author(s): 柿沼志津子, 他
  • Organizer: 第24回発癌病理研究会
  • Place of Presentation: 七尾市
• [Presentation] 放射線発がんの被ばく時年齢依存性:実験動物乳がんモデルを中心に (2009)
  • Author(s): 今岡達彦, 他
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島市
• [Presentation] Mlh1欠損マウスに発生する腸管腫瘍の被ばく時年齢依存性 (2009)
  • Author(s): 柿沼志津子, 他
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島市
• [Presentation] 「放射線防護」と若手研究者～アンケート調査から～ (2009)
  • Author(s): 今岡達彦, 他
  • Organizer: 京都大学原子炉専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] Epigenetic gene regulation during mammary gland morphogenesis (2009)
  • Author(s): Kazuhiro Daino, et al.
  • Organizer: IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: 千葉市
• [Presentation] Detailed analysis of Ikaros mutation in mouse thymic lymphoma induced by simultaneous exposure of X-rays and N-ethyl-N-nitrosourea (2009)
  • Author(s): Yoshiko Amasaki, et al.
  • Organizer: 2nd Asian Congress of Radiation Research
  • Place of Presentation: 韓国、漢城市
• [Presentation] Comparison of Ikaros, p53 and Kras point mutation in mouse thymiclymphomas induced by simultaneous exposure to X-ray and N-ethvl-N-nitrosourea (2009)
  • Author(s): Shinobu Hirano, et al.
  • Organizer: 2nd Asian Congress of Radiation Research
  • Place of Presentation: 韓国、漢城市
• [Presentation] Influence of co-exposure to gamma-rays on the manifestation of MNU- or PhiIP-induced mutations in rat mammary carcinomas (2009)
  • Author(s): Mayumi Nishimura, et al.
  • Organizer: 2nd Asian Congress of Radiation Research
  • Place of Presentation: 韓国、漢城市
• [Presentation] ラット放射線誘発乳がんにおけるLOHとDNAコピー数の解析 (2009)
  • Author(s): 西村まゆみ, 他
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島市
• [Presentation] Detailed analysis of Ikaros mutations in mouse thymic lymphoma induced by simultaneous exposure to X-rays and N-ethyl-N-nitrosourea (2009)
  • Author(s): Yoshiko Amasaki, et al.
  • Organizer: IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: 千葉市
• [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA発現の網羅的解析 (2009)
  • Author(s): 飯塚大輔, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
• [Presentation] DNA copy number changes in radiation-induced mammary carcinomas in (SDxCOP)F1 rats (2009)
  • Author(s): Mayumi Nishimura, et al.
  • Organizer: IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: 千葉市
• [Presentation] Altered expression of microRNAs in radiation-induced rat mammary carcinoma (2009)
  • Author(s): Daisuke Iizuka, et al.
  • Organizer: IAEA NIRS Joint Workshop & NIRS Symposium on Radiation Protection for Children
  • Place of Presentation: 千葉市
• [Presentation] Genetic changes in heavyion-induced T-cell lymphomas in B6C3F1 mice (2009)
  • Author(s): Erika Takahashi, et al.
  • Organizer: 第23回日本宇宙生物科学会
  • Place of Presentation: つくば市
• [Presentation] Experimental research on radiation health effects on children (2009)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: Third Conference on Children's Environmental Health, World Health Organization
  • Place of Presentation: 韓国、釜山市
• [Presentation] 化学発がんに及ぼす低線量放射線の影響について (2009)
  • Author(s): 島田義也, 他
  • Organizer: 量子ビーム応用研究開発部門研究交流会
  • Place of Presentation: 茨城県東海村
• [Presentation] 胎児・小児の放射線リスク (2009)
  • Author(s): 島田義也, 他
  • Organizer: 日本放射線技術学会第65回大会
  • Place of Presentation: 横浜市
• [Presentation] Molecular signature in radiation-induced T-cell lymphomas (2009)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: 2nd Asian Congress of Radiation Research
  • Place of Presentation: 韓国、漢城市
• [Presentation] Modification of threshold dose in radiation-induced mouse lymphoma development (2008)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: International Symposium on Genotoxic and Carcinogenic Thresholds
  • Place of Presentation: 東京
  • Year and Date: 2008-07-23
• [Presentation] 重粒子線のラット乳がん誘発作用 (2008)
  • Author(s): 今岡達彦、西村まゆみ、飯塚大輔、柿沼志津子、島田義也
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州
• [Presentation] 電離放射線およびメチルニトロソ尿素によるラット乳がん誘発作用の年齢依存性およびそのメカニズム (2008)
  • Author(s): 今岡達彦、西村まゆみ、島田義也
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 電離放射線およびメチルニトロソ尿素によるラット乳がん誘発作用の年齢依存性およびそのメカニズム (2008)
  • Author(s): 今岡達彦、西村まゆみ、波多野由希子、飯塚大輔、柿沼志津子、島田義也
  • Organizer: 平成20年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] 放射線誘発ラット乳がんにおけるゲノムコピー数異常の網羅的解析 (2008)
  • Author(s): 飯塚大輔、今岡達彦、高畠貴志、西村まゆみ、柿沼志津子、波多野由希子、島田義也
  • Organizer: 平成20年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府泉南郡
• [Presentation] 重粒子線のラット乳がん誘発作用 (2008)
  • Author(s): 今岡達彦、他
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州市
• [Presentation] Possible fingerprints of radiation-induced mammary cancers in rats (2008)
  • Author(s): Tatsuhiko Imaoka
  • Organizer: Workshop on "Radiation Risk of Breast Cancer : what can/should we do in the future? "
  • Place of Presentation: 広島市
• [Presentation] Expression and promoter methylation of Sic family genes in rat mammary carcinomas induced by different etiologies (2008)
  • Author(s): Mayumi Nishimura, et al.
  • Organizer: The 26th Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 倉敷市
• [Presentation] Minマウスにおける放射線発がん機構の解析 (2008)
  • Author(s): 岡本美恵子、他
  • Organizer: 第23回発癌病理研究会
  • Place of Presentation: 鳥羽市
• [Presentation] 放射線と化学物質の複合曝露によるマウス胸腺リンパ腫の発生とIkarosの変異解析 (2008)
  • Author(s): 柿沼志津子、他
  • Organizer: 京都T細胞会議第18回学術研究集会
  • Place of Presentation: 京都市
• [Presentation] 宇宙放射線によるマウスの寿命短縮効果 (2008)
  • Author(s): 柿沼志津子、他
  • Organizer: 日本宇宙生物科学会第22回大会
  • Place of Presentation: 橿原市
• [Presentation] 低線量放射線はエチルニトロソウレアによるT細胞白血病発生を抑制する (2008)
  • Author(s): 柿沼志津子、他
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州市
• [Presentation] ミスマッチ修復欠損マウスにおける放射線発がんの特徴 (2008)
  • Author(s): 島田義也、他
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州市
• [Presentation] マウスTリンパ腫におけるIkarosならびにp53変異の系統差 (2008)
  • Author(s): 高橋江里佳、他
  • Organizer: 日本宇宙生物科学会第22回大会
  • Place of Presentation: 橿原市
• [Presentation] 放射線と化学物質の同時複合曝露によるマウス胸腺リンパ腫発生における被ばく時年齢の影響 (2008)
  • Author(s): 甘崎佳子、他
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州市
• [Presentation] 放射線と化学物質の複合曝露によって誘発されたマウス胸腺リンパ腫におけるKrasとIkarosの突然変異 (2008)
  • Author(s): 古渡礼恵、他
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州市
• [Presentation] Radiation accelerated carcinogenesis in M1h1 knockout mice (2008)
  • Author(s): Yoshiya Shimada, et al.
  • Organizer: International Symposium on Carcinogenesis and Genetic Effects of Low Dose Radiation Exposure
  • Place of Presentation: 青森県上北郡
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