Genome-wide screening of functional ribozymes by in vivo selection
| Project/Area Number |
20710167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
HAGIHARA Masaki Osaka University, 産業科学研究所, 助教 (40403000)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リボザイム / in vivoセレクション / ゲノム |
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| Research Abstract |
In vitro selection provides one of the most powerful strategies for obtaining functional RNA molecules. The selection and evolution technique has produced RNA aptamers that specifically bind small molecules or ribozymes that catalyze a variety of chemical reactions from randomized pools of RNA. In this project, we performed an in vitro selection aimed at isolating functional RNAs from the human genome RNA library.
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Report
(3 results)
Research Products
(23 results)
