Functional analysis of D-proline and proline racemase in lipid metabolism

Research Project

Project/Area Number	20710169
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Living organism molecular science
Research Institution	Saitama Medical University
Principal Investigator	YOSHIKAWA Naoko Saitama Medical University, 理工学部, 講師 (30392533)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	生体機能関連物質 / ラセマーゼ / D-プロリン / D型アミノ酸 / 脂肪組織 / 酵素 / プロリンラセマーゼ
Research Abstract	D-Proline (Pro) is found in several tissues of mice. The synthetic pathway of D-Pro in microorganisms is known to produce by racemase which catalyzes interconversion of D- or L-Pro. We detected proline racemase like gene expression (MPR) in mice. MPR was expressed in mice adipose tissues specificity, and translated into protein. Moreover, the expression level of MPR in adipose tissues was decreased in high fat dietary mice. It suggests that MPR is concerned to lipid metabolism in mice.

Report

(3 results)