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Understanding of cooperative actions between skeletal myosin molecules

Research Project

Project/Area Number 20740238
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biophysics/Chemical physics
Research InstitutionThe University of Tokyo

Principal Investigator

KAYA Motoshi  The University of Tokyo, 大学院・理学系研究科, 助教 (00422098)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords生物物理 / ミオシン / 1分子計測 / 筋肉 / スティフネス / 骨格筋ミオシン / ナノバイオ
Research Abstract

I have tried to capture the "true" mechanical properties of single skeletal myosins by measuring the displacement and force generated by single myosins arranged in myosin-rod cofilaments, which is more natural environment than the typical experimental setup designed in the previous single molecule studies. It was found that the elastic properties of single myosins is non-linear. When a myosin is stretched, it becomes stiffer so that it can generate a large amount of force with a small stretching, while it becomes much softer to reduce the resistance force when it is compressed. Therefore, the non-linear elasticity may be an ingenious mechanical property to achieve muscle contractions efficiently without the molecular interference between motors.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Presentation (10 results)

  • [Presentation] 1分子ナノ計測による骨格筋ミオシンの力発生機構2010

    • Author(s)
      茅元司樋口秀男
    • Organizer
      ナノ学会第8回大会
    • Place of Presentation
      岡崎カンファレンスセンター
    • Year and Date
      2010-05-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Non-linear elasticity of single skeletal myosin is an essential mechanical property of muscle contraction. International Society of Biomechanics XXII Congress2009

    • Author(s)
      Motoshi Kaya, Hideo Higuchi
    • Organizer
      Cape town
    • Place of Presentation
      South Africa
    • Year and Date
      2009-07-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 量子ドットを用いた1分子ナノ計測によりわかってきた骨格筋ミオシンの非線形弾性と力発生へのその役割2009

    • Author(s)
      茅元司樋口秀男
    • Organizer
      ナノ学会第7回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Non-linear elasticity of single skeletal myosin is an essential mechanical property of muscle contraction2009

    • Author(s)
      茅元司
    • Organizer
      International Society of Biomechanics XXII Congress
    • Place of Presentation
      Cape Town, 南アフリカ
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨格筋ミオシン2分子から多分子化にともなう運動の変化2008

    • Author(s)
      茅元司
    • Organizer
      タンパク質2分子計測ワークショップ
    • Place of Presentation
      東京大学
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨格筋ミオシンのステップサイズは負荷に伴い減少する2008

    • Author(s)
      茅元司樋口秀男
    • Organizer
      第46回日本生物物理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Mechanism of mechanical work and efficiency enhancement in myosin assembly2008

    • Author(s)
      Motoshi Kaya
    • Organizer
      2nd International Symposium on Bio-nanosystems
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組換単頭ダイニン2分子のステップサイズは広く分散する2008

    • Author(s)
      HoaAnh Nguyen茅元司昆 隆英島 知弘須藤和夫樋口秀男
    • Organizer
      生体運動合同班会議
    • Place of Presentation
      仙台
    • Year and Date
      2008-01-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Stroke size of single skeletal myosin changes with loads due to non-linear elasticity of myosin2008

    • Author(s)
      Motoshi Kaya, Hideo Higuchi
    • Organizer
      Gordon Conference
    • Place of Presentation
      MA USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Stroke size of single skeletal myosin changes with loads due to non-linear elasticity of myosin2008

    • Author(s)
      Motoshi Kaya
    • Organizer
      Gordon Conference
    • Place of Presentation
      New England NH, USA
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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