Ubiquitous Element "Iron"-mediated Preparation of Polyfunctionalized Cyclic Compounds
| Project/Area Number |
20750071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
HATA Takeshi Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (40419271)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ユビキタス元素 / 鉄 / 官能基共存型反応 / グリニャール試薬 / 多官能性環状化合物 / 鉄触媒 / ジマグネシオ体 / 分子内環化反応 / 低原子価鉄試薬 / 官能性エンイン / 官能性アセチレン-鉄錯体 / 官能性オレフィン-鉄錯体 / 分子内アルキル化反応 / シクロペンタン / グリニヤール試薬 / 官能性オレフンー鉄錯体 / メタラサイクル / 分子内タンデム環化反応 / 双環性ケトエステル / 官能基 |
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| Research Abstract |
Iron reagent generated from FeCl_2 and Grignard reagent is useful for metallative cyclization of functionalized acetylenes and olefins, which subsequently enables the preparation of various kinds of polifunctionalized cyclic products. In an enyne cyclization, the quantity of the iron salt can be reduced to a catalytic level.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Iron Catalyst-Switched Selective Conjugate Addition of Grignard Reagents.α, β, γ, δ-Unsaturated Amides as a Versatile Template for Asymmetric Three-Component Coupling Process2008
Author(s)
岡田悟史, 荒山恭平, 村山隆二, 石塚匠, 原圭一, 広根直樹, 秦猛志, 占部弘和
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Journal Title
Angew.Chem.Int.Ed. 47
Pages: 6860-6864
Related Report
Peer Reviewed
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[Journal Article] Iron Catalyst-Switched Selective Conjugate Addition of Grignard Reagents. a, B, γ, δ-Unsaturated Amides as a Versatile Template for Asymmetrie Three-Component Coupling Process2008
Author(s)
Satoshi Okada, Kyohei Arayama, Ryuji Murayama, Takumi Ishizuka, Keiichi Hara, Naoki Hirone, Takeshi Hata, and Hirokazu Urabe
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Journal Title
Angewandte Chemie International Edition in English 47
Pages: 6860-6864
Related Report
Peer Reviewed
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